Conclusion
1-Aryl-10-methylpyrazino(1,2-a)indoles are prepared by the condensation of ammonium acetate in acetic acid solution and the dibutyl acetals of 2-aroylindolyl-1-acetaldehydes which are formed by the reaction of the sodium derivatives of 2-aroyl-3-methylindoles with bromoacetaldehyde dibutyl acetal. 1-Aryl-1,2,3,4-tetrahydro-10-methylpyrazino(l,2-a)indoles are prepared by the reduction of the 1-aryl-10-methylpyrazinoindoles with sodium in alcohol. Furthermore, the synthesis of N-alkyl-dialkylamino derivatives of the 2-aroyl-3-methylindoles are carried out by the alkylation of the appropriate indoles with bisdiethylaminomethane and alkyldialkylamino chlorides.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
R. A. Abramovitch and L. D. Spenser, Advances in Heterocyclic Chemistry, Vol. 3, London (1964), p. 79.
V. I. Shvedov, L. B. Altukhova, and A. N. Grinev, Authors Certificate No. 194827; Izobreteniya No. 9, 45 (1967).
V. I. Shvedov, L. B. Altukhova, and A. N. Grinev, Khim-Farmats. Zh., No. 3, 25 (1967).
V. I. Shvedov, V. V. Alekseev, and A. N. Grinev, Authors Certificate No. 215217; Izobreteniya, No. 13, 20 (1968).
J. D. Butcher, J. R. Johnson, and W. F. Bruce, J. Amer. Chem. Soc.,67, 1736 (1945).
J. A. Elvidge, and F. S. Spring, J. Chem. Soc., 135 (1949).
C. Ganellin and H. Ridley, Chem. and Ind., 1388 (1964).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 12, pp. 3–7, December, 1968.