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Studies of the imidazole series.

XLIII. synthesis of 4(5)-nitro-5(4)-bromoimidazoles by bromination of 4(5)-nitroimidazoles

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Pharmaceutical Chemistry Journal Aims and scope

Conclusions

The bromination of 2-alkyl-4(5)-nitro-, 1,2-dialkyl-4-nitro-, and 1,2-dialkyl-5-nitroimidazoles was studied and at the same time a simple method was devised for obtaining 2-alkyl-4(5)-nitro-5(4)-bromo- and 1,2-dialkyl-4-nitro-5-bromoimidazoles. 1,2-Dialkyl-5-nitroimidazoles cannot be brominated. 1,2-Dialkyl-4-bromo-5-nitroimidazoles can be obtained by alkylation of 2-alkyl-4(5)-nitro-5(4)-bromoimidazoles by dialkyl sulfates.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific Research Institute of Pharmaceutical Chemistry, Moscow

    P. M. Kochergin, A. M. Tsyganova & V. S. Shlikhunova

Authors
  1. P. M. Kochergin
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  2. A. M. Tsyganova
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  3. V. S. Shlikhunova
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 22–25, October, 1968.

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Kochergin, P.M., Tsyganova, A.M. & Shlikhunova, V.S. Studies of the imidazole series.. Pharm Chem J 2, 549–552 (1968). https://doi.org/10.1007/BF00759631

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  • DOI: https://doi.org/10.1007/BF00759631

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