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Chronic relapsing experimental allergic encephalomyelitis

Studies in vascular permeability changes

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Summary

The vascular permeability in the nervous system to Evans blue-albumin and horseradish peroxidase was studied in chronic relapsing EAE in strain 13 and Hartley guinea pigs. The disease was induced by single sensitization of immature animals and was characterized clinically by remissions and relapses. Recent and old demyelinating plaques in the spinal cord were present. These showed an increased permeability to the protein tracers. The blood-brain barrier in these plaques are therefore disturbed and also in this respect the condition is similar to the multiple sclerosis lesions.

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Authors and Affiliations

  1. Neuropathological Laboratory, Department of Pathology II, University of Linkoping, Sweden

    Krister Kristensson & Henryk M. Wiśniewski

  2. Medical Research Council Demyelinating Diseases Unit, Newcastle upon Tyne, England

    Krister Kristensson & Henryk M. Wiśniewski

  3. New York State Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, 10314, Staten Island, New York, USA

    Krister Kristensson & Henryk M. Wiśniewski

Authors
  1. Krister Kristensson
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  2. Henryk M. Wiśniewski
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Kristensson, K., Wiśniewski, H.M. Chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol 39, 189–194 (1977). https://doi.org/10.1007/BF00691696

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  • DOI: https://doi.org/10.1007/BF00691696

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