Acta Neuropathologica

, Volume 18, Issue 2, pp 144–149 | Cite as

Suppression of experimental allergic neuritis in rats by prior immunization with nerve in saline

  • James R. Lehrich
  • Barry G. Arnason
Original Investigations


Rats given nerve in saline intraperitoneally failed to develop allergic neuritis when challenged with nerve in adjuvant 2 weeks later. The serum of protected rats prevented sensitized lymph node cells, from rats immunized only with nerve in adjuvant, from demyelinating rat peripheral nerve cultures.


Allergic Neuritis Enhancement Demyelination Nerve Tissue Culture Delayed Hypersensitivity 


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  1. Arnason, B. G., George, K.: Unpublished observations.Google Scholar
  2. —, Winkler, G. F., Hadler, N. M.: Cell-mediated demyelination of peripheral nerve in tissue culture. Lab. Invest.21, 1–10 (1969).Google Scholar
  3. Asherson, G. L., Stone, S. H.: Selective and specific inhibition of 24-hours skin reactions in the guinea pigs. I. Immune deviation: description of the phenomenon and the effect of splenectomy. Immunology9, 205–217 (1965).Google Scholar
  4. Astrom, K. E., Webster, H. de F., Arnason, B. G.: The initial lesion in experimental allergic neuritis. A phase and electron microscopic study. J. exp. Med.128, 469–495 (1968).Google Scholar
  5. Axelrad, M., Rowley, D. A.: Hypersensitivity: specific immunologic suppression of the delayed type. Science160, 1465–1467 (1968).Google Scholar
  6. Billingham, R. E., Brent, L., Medawar, P. B.: Enhancement in normal homografts, with a note on its possible mechanism. Transplant. Bull.3, 84–88 (1956).Google Scholar
  7. Bornstein, M. B., Iwanami, H.: Experimental allergic encephalomyelitis: In vitro demyelination produced by sensitized rat lymph node cells and serum. J. Neuropath. exp. Neurol.24, 146–147 (1970).Google Scholar
  8. Boyden, S. V.: The effect of previous injections of tuberculo-protein on the development of tuberculin sensitivity following BCG vaccination in guinea pigs. Brit. J. exp. Path.38, 611–617 (1957).Google Scholar
  9. Brondz, B. D.: Interaction of immune lymphocytesin vitro with normal and neoplastic tissue cells. Folia biol. (Praha)10, 164–176 (1964).Google Scholar
  10. Brunner, K. T., Mauel, J., Cerottini, J. C., Chapuis, B.: Quantitative assay of the lytic action of immune lymphoid cells on51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunology14, 181–196 (1968).Google Scholar
  11. Chutnà, J.: Prolonged survival of H.2 different skin allografts in mice specifically immunized with lyophilized spleens in Freund's adjuvant. Folia biol. (Praha)14, 140–147 (1968).Google Scholar
  12. —, Rychlikowa, M.: A study of the biological effectiveness of antibodies in the development and prevention of experimental autoimmune aspermatogenesis. Folia biol. (Praha)10, 188–197 (1964).Google Scholar
  13. Falk, G. A., Heinze, R. G., Kies, M. W., Alvord, E. C.: Skin fixing antibody in experimental allergic encephalomyelitis. J. Immunol.100, 321–328 (1968).Google Scholar
  14. Ferraro, A., Cazzullo, C. L.: Prevention of experimental allergic encephalomyelitis in guinea pigs. J. Neuropath. exp. Neurol.8, 61–69 (1949).Google Scholar
  15. Field, E. J., Caspary, E. A.: Protective effect of encephalitogenic factor in experimental allergic encephalomyelitis. Nature (Lond.)201, 936 (1964).Google Scholar
  16. French, M. E., Batchelor, J. R.: Immunological enhancement of rat kidney grafts. Lancet1969 II, 1103–1106.Google Scholar
  17. Gordon, J.: The prevention of delayed hypersensitivity to homologous serum and transplantation antigens in guinea pigs. Immunology5, 153–160 (1962).Google Scholar
  18. Jankovic, B. D., Flax, M. H.: Alterations in the development of experimental allergic thyroiditis induced by injection of homologous thyroid extract. J. Immunol.90, 178–184 (1963).Google Scholar
  19. Kaliss, N.: The survival of homografts in mice pretreated with antisera to mouse tissue. Ann. N. Y. Acad. Sci.64, 977–990 (1957).Google Scholar
  20. —: Immunological enhancement of tumor homografts in mice: a review. Cancer Res.18, 992–1003 (1958).Google Scholar
  21. Koprowski, H., Fernandes, M. V.: Autosensitization reactionin vitro. Contactual agglutination of sensitized lymph node cells in brain tissue culture accompanied by destruction of glial elements. J. exp. Med.116, 467–476 (1962).Google Scholar
  22. Kosunen, T. U., Waksman, B. H., Samuelsson, I.: Radioautographic study of cellular mechanisms in delayed hypersensitivity. II. Experimental allergic encephalomyelitis in the rat. J. Neuropath. exp. Neurol.22, 367–380 (1963).Google Scholar
  23. Möller, E.: Antagonistic effects of humoral isoantibodies on thein vitro cytotoxicity of immune lymphoid cells. J. exp. Med.122, 11–23 (1965).Google Scholar
  24. Nelson, D. S.: Immunological enhancement of skin homografts in guinea pigs. Brit. J. exp. Path.43, 1–11 (1962).Google Scholar
  25. Paterson, P. Y.: Experimental allergic encephalomyelitis and auto-immune disease. Advanc. Immunol.5, 131–208 (1966).Google Scholar
  26. —, Harwin, S. M.: Suppression of allergic encephalomyelitis in rats by means of antibrain serum. J. exp. Med.117, 755–774 (1963).Google Scholar
  27. Salvin, S. B., Liauw, H. L.: Immunologic unresponsiveness, immunity and enhancement in experimental allergic encephalomyelitis. J. Immunol.101, 33–42 (1968).Google Scholar
  28. Snell, G. D., Winn, H. J., Stimpfling, J. H., Parker, S. J.: Depression by antibody of the immune response to homografts and its role in immunological enhancement. J. exp. Med.112, 293–314 (1960).Google Scholar
  29. Stuart, F. P., Saitoh, T., Fitch, F. W.: Rejection of renal allografts: specific immunologic suppression. Science160, 1463–1465 (1968).Google Scholar
  30. Voisin, G. A., Kinsky, R., Maillard, J.: Modification de la maladie homologue des souris nouveau-nées, par facilitation immunologique (enhancement phenomenon), induite, passivement et activement. In: La greffe des cellules hématopoiétiques allogéniques. pp. 407–430. Paris: C.N.R.S. 1965.Google Scholar
  31. ———: Protection against homologous disease in hybrid mice by passive and active immunological enhancement-facilitation. Transplantation6, 187–202 (1968).Google Scholar
  32. Waksman, B. H.: Allergic encephalomyelitis in rats and rabbits pretreated with nervous tissue. J. Neuropath. exp. Neurol.18, 397–417 (1959).Google Scholar
  33. Wilson, D. B.: Quantitative studies on the behavior of sensitized lymphocytes in vitro. I. Relationship of the degree of destruction of homologous target cells to the number of lymphocytes and to the time of contact in culture and consideration of the effects of isoimmune serum. J. exp. Med.122, 143–166 (1965).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • James R. Lehrich
    • 1
    • 2
  • Barry G. Arnason
    • 1
    • 2
  1. 1.Department of NeurologyMassachusetts General HospitalBostonUSA
  2. 2.Harvard Medical SchoolBoston

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