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The Effects of Haloperidol on the Progression of Chronic Autoimmune Inflammation Induced by Freund’s Adjuvant

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Abstract

Prophylactic administration to rats with the model of chronic autoimmune inflammation, induced by Freund’s adjuvant, of a typical neuroleptic haloperidol at a dose of 0.1 mg/kg increased the intensity of the primary inflammatory response (arthritis) and inhibited progression of the secondary arthritis.

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References

  1. Alamanos, Y., Voulgari, P. V., & Drosos, A. A. (2006). Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Seminars in Arthritis and Rheumatism, 36, 182–188.

    Article  Google Scholar 

  2. Scott, D. L., Wolfe, F., & Huizinga, T. W. (2010). Rheumatoid arthritis. Lancet, 376, 1094–1108.

    Article  Google Scholar 

  3. Firestein, G. S. (2003). Evolving concepts of rheumatoid arthritis. Nature, 423, 356–361.

    Article  Google Scholar 

  4. Mironov, A. Guidelines for conducting the pre-clinical research of medication. M: 2012. T.1. p. 940.

  5. Sawynok, J., Esser, M. J., & Reid, A. R. (1999). Pain (Netherlands), 82(2), 149–158.

  6. Cruz Jung, I. E., Machado, A. K., da Cruz, I. B., Barbisan, F., Azzolin, V. F., Duarte, T., Duarte, M. M., do Prado-Lima, P. A., Bochi, G. V., Scola, G., & Moresco, R. N. (2016). Haloperidol and risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels. Psychopharmacology, 233(9), 1715–1723. doi:10.1007/s00213-015-4079-7 .PMID: 26391290.

    Article  Google Scholar 

  7. Baumeister, D., Ciufolini, S., & Mondelli, V. (2016). Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment? Psychopharmacology, 233, 1575. doi:10.1007/s00213-015-4044-5.

  8. GOST Р 50258–92 All-in-one feeds for laboratory animals. Technical conditions.

  9. On the approval of the Rules of Laboratory Practice: order of the Health Ministry of the Russian Federation dated August 23, 2010 N 708n: Registered at the Ministry of Justice of the Russian Federation, October 13, 2010 N 18713 // Ros.gaz. October 22, 2010.

  10. Online resource: European Convention for the protection of vertebrate animals used for experimental and other scientific purposes, 1986. http://www.lawmix.ru/abro.php?id=11036. Accessed 29 April 2014.

  11. Gazerani, S., Zaringhalam, J., Manaheji, H., & Golabi, S. (2016). The role of C fibers in spinal microglia induction and possible relation with TRPV3 expression during chronic inflammatory arthritis in rats. Basic and Clinical Neuroscience, 7(3), 231–240. doi:10.15412/J.BCN.03070308.

  12. Shabbir, A., Shahzad, M., Ali, A. et al. (2016). Inflammation. doi: 10.1007/s10753-016-0427-y, http://link.springer.com/article/10.1007%2Fs10753-016-0427-y.

  13. Ialenti, A., Ianaro, A., Moncado, S., & DiRosa, M. (1992). European Journal of Pharmacology, 211(4), 177–182.

  14. Federal drug registry: http://www.rlsnet.ru/mnn_index_id_114.htm. Accessed September 2016.

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Acknowledgements

The work is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University.

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Authors and Affiliations

  1. Department of Basic and Clinical Pharmacology, Kazan Federal University, 18 Kremlevskaya str, Kazan, 420008, Russia

    Veronika Khaziakhmetova, Sania Miryakupova, Almaz Dzhamalbekov, Kairat Baiysbekov, Shamil Torobekov & Liliya Ziganshina

  2. University Clinic KFU, Kazan Federal University, 1a Chekhov str, Kazan, 420043, Russia

    Veronika Khaziakhmetova

Authors
  1. Veronika Khaziakhmetova
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  2. Sania Miryakupova
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  3. Almaz Dzhamalbekov
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  4. Kairat Baiysbekov
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  5. Shamil Torobekov
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  6. Liliya Ziganshina
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Corresponding author

Correspondence to Veronika Khaziakhmetova.

Ethics declarations

The studies were performed in conformity with the good laboratory practice rules (GLP) when conducting preclinical research in the Russian Federation [9] as well as in accordance with the Rules and International Recommendations of the European Convention for the Protection of Vertebrate Animals used for Experimental Purposes (1986) [10]. The local ethics committee approved the study (Protocol number 3/6 dated 4th of May 2011, the Ethics Committee of the Kazan State Medical Academy).

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Khaziakhmetova, V., Miryakupova, S., Dzhamalbekov, A. et al. The Effects of Haloperidol on the Progression of Chronic Autoimmune Inflammation Induced by Freund’s Adjuvant. BioNanoSci. 7, 428–430 (2017). https://doi.org/10.1007/s12668-016-0381-z

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  • DOI: https://doi.org/10.1007/s12668-016-0381-z

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