Summary
The distribution of the brain specific proteins, S-100 and 14.3.2, was studied in 80 human brain tumors by means of immunofluorescence and immunoprecipitation techniques. The following observations were made:
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1.
Both the S-100 and 14.3.2 proteins were shown to be present within nerve cells of human frontal lobes.
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2.
Both the S-100 and the 14.3.2 proteins were shown to be present in the cells of such gliomas as glioblastomas, astrocytomas, spongioblastomas and acoustic neurinomas and some oligodendrogliomas.
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3.
The 14.3.2 protein, but not the S-100 protein, could be demonstrated in ependymomas, plexus papillomas and chromophobe adenomas of the pituitary and in three polymorphous oligodendrogliomas.
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4.
None of the proteins were found to be present in necrotic areas of brain tumors or in meningiomas and brain metastases.
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Haglid, K., Carlsson, C.A. & Stavrou, D. An immunological study of human brain tumors concerning the brain specific proteins S-100 and 14.3.2. Acta Neuropathol 24, 187–196 (1973). https://doi.org/10.1007/BF00687589
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DOI: https://doi.org/10.1007/BF00687589