Summary
The case is described of an elderly female mongol (trisomy 21) who in life displayed clinical features of a paranoid psychosis and who, at eventual neuropathological examination, was found to have unusual histological changes in the brain consisting of giant cell arteritis and arteriolitis complicated by amyloid degeneration. The significance of these changes and their relationship to the neuropathological changes of senile and presenile dementia is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Calkins, E.: In: Amyloidosis, ed. by E. Madema, L. Ruinen, J. H. Scholten, and A. S. Cohen, pp. 87–99. Amsterdam: Excerpta Med. 1968.
Corsellis, J. A. N., Brierley, J. B.: An unusual type of presenile dementia. (Atypical Alzheimer's disease with amyloid vascular change. Brain77, 571–587 (1954)
Divry, P.: Proc. 1st Int. Cong. Path. Nerv. Syst., Rome, pp. 313–345 (1952)
Fish, F.: Clinical presentation and classification of schizophrenia. Hosp. Med.1, 566–571 (1967)
Gerhard, L., Bergener, M., Homayun, S.: Angiopathie bei Alzheimerscher Krankheit. Z. Neurol.201, 43–61 (1972)
Hollander, D., Strich, S.: Atypical Alzheimer's disease with congophilic angiopathy presenting with dementia of acute onset. In: CIBA Foundation Symposium on Alzheimer's Disease and Related Conditions. Ed. G. E. W. Wolstenholm and M. O'Connor, pp. 105–123 (1970)
Lancet Annotation: Amyloidosis of Alzheimer's disease: a clue to ageing? Lancet1970 II, 598–599
McCormick, H. M., Neubuerger, K. T.: Giant cell arteritis involving small meningeal and intracerebral vessels. J. Neuropath. exp. Neurol.17, 471–478 (1958)
Neumann, M. A.: Combined amyloid vascular changes and argyrophilic plaques in the central nervous system. J. Neuropath. exp. Neurol.19, 370–382 (1960)
Olson, M. I., Cheng-Mei Shaw: Presenile dementia and Alzheimer's disease in mongolism. Brain92, 147–156 (1969)
Pantelakis, S.: Un type particulier d'angiopathie sénile du système nerveux central: l'angiopathie congophile. Topographie et fréquence. Mschr. Psychiat. Neurol.128, 219–256 (1954)
Reid, A. H.: Psychoses in adult mental defectives: II. Schizophrenic and paranoid psychoses. Brit. J. Psychiat.120, 213–218 (1972)
Reid, A. H., Aungle, P. G.: Dementia in ageing mental defectives: a clinical psychiatric study. J. ment. Defic. Res. (in press)
Richards, B. W.: Old age and the mentally retarded. In: Modern perspectives in psychogeriatrics (Ed. J. G. Howells). Edinburgh: Oliver and Bod (in press)
Schlote, W.: Die Amyloidnatur der kongophilen drusigen Entartung der Hirnarterien (Scholz) in Senium. Acta neuropath. (Berl.)4, 449–468 (1965)
Scholz, W.: Studien zur Pathologie der Hirngefäße II. Die drusige Entartung der Hirnarterien und-capillaren. Z. ges. Neurol. Psychiat.162, 694–715 (1938)
Schwartz, P.: In: Pathology of the nervous system, Vol. 3, pp. 2812–2849. Ed. by J. Minckler & McGraw Hill 1972
Smith, K. R.: Electron microscopy of giant cell (temporal) arteritis. J. Neurol. Neurosurg. Psychiat.32, 348–353 (1969)
Symmers, W. St. C.: Primary amyloidosis. A review. J. clin. Path.9, 187–211 (1956)
Teilum, G.: In: Amyloidosis. ed. by E. Madema, L. Ruinen, J. H. Scholten, and A. S. Cohen, pp. 37–44. Amsterdam: Excerpta med. 1968
Worster-Drought, C., Greenfield, J. G.: McMenemey, W. H.: A form of familial presenile dementia with spastic paralysis. Brain63, 237–254 (1940)
Worster-Drought, C., Greenfield, J. G., McMenemey, W. H.: A form of familial presenile dementia with spastic paralysis. Brain67, 38–43 (1944)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Reid, A.H., Maloney, A.F.J. Giant cell arteritis and arteriolitis associated with amyloid angiopathy in an elderly mongol. Acta Neuropathol 27, 131–137 (1974). https://doi.org/10.1007/BF00687163
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00687163