Acta Neuropathologica

, Volume 75, Issue 2, pp 166–172 | Cite as

Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E

  • A. Bardosi
  • U. Dickmann
Regular Papers


A necrotizing, nonprogressive myopathy with unusual paracrystalline inclusion bodies is described in a patient who underwent long-term treatment with megadoses of vitamin E. The clinical course and morphological findings suggest a close relationship to the administration of the vitamin. The theoretical pathogenesis of muscle damage and the possible origin of paracrystalline inclusion bodies are discussed.

Key words

Hypervitaminosis E Myopathy Inclusion body 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Bardosi
    • 1
  • U. Dickmann
    • 2
  1. 1.Department of NeuropathologyUniversity of GöttingenGöttingenGermany
  2. 2.Department of NeurologyUniversity of GöttingenGöttingenGermany

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