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Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E

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Summary

A necrotizing, nonprogressive myopathy with unusual paracrystalline inclusion bodies is described in a patient who underwent long-term treatment with megadoses of vitamin E. The clinical course and morphological findings suggest a close relationship to the administration of the vitamin. The theoretical pathogenesis of muscle damage and the possible origin of paracrystalline inclusion bodies are discussed.

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Authors and Affiliations

  1. Department of Neuropathology, University of Göttingen, Robert-Koch-Strasse 40, D-3400, Göttingen, Germany

    A. Bardosi

  2. Department of Neurology, University of Göttingen, Robert-Koch-Strasse 40, D-3400, Göttingen, Germany

    U. Dickmann

Authors
  1. A. Bardosi
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  2. U. Dickmann
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This study was supported by a grant from the Deutsche Forschungsgemeinschaft (Ba 916)

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Bardosi, A., Dickmann, U. Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E. Acta Neuropathol 75, 166–172 (1987). https://doi.org/10.1007/BF00687078

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  • DOI: https://doi.org/10.1007/BF00687078

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