Skip to main content
SpringerLink
Log in

Methylphosphonothionates of N-(β-hydroxypropyl)anabasine — Synthesis, structure, and sensitivity of cholinesterases to them

  • Published:
Chemistry of Natural Compounds Aims and scope

Abstract

The synthesis has been effected of alkyl anabasinoprop-2-yl and alkyl piperidinoprop-2-yl methylphosphonothionates. It has been shown by1H,13C and31P NMR spectroscopies that the anabasine derivatives exist in solution as four diastereomeric forms. The kinetics of the interaction of the compounds synthesized with two types of cholinesterases has been studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T. H. Siddall and W. E. Stewart, Progr. NMR Spectrosc.,5, 33 (1969).

    Google Scholar 

  2. M. Mikolaichik and M. Leitloff, Usp. Khim.,44, No. 8, 1419 (1975).

    Google Scholar 

  3. T. A. Mastryukova, A. É. Shipov, M. S. Vaisberg, P. V. Petrovskii, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim., 1841 (1971).

  4. M. I. Kabachnik and N. N. Godovikov, Dokl. Akad. Nauk SSSR,110, 210 (1956).

    Google Scholar 

  5. A. A. Abduvakhabov, N. N. Godovikov, and M. I. Kabachnik, The Chemistry of Organic Compounds of Phosphorus [in Russian], Nauka, Leningrad (1967), p. 3.

    Google Scholar 

  6. A. S. Sadykov, The Chemistry of the Alkaloids ofAnabasis aphylla [in Russian], Izd-vo Akad. Nauk UzSSR, Tashkent (1956).

    Google Scholar 

  7. D. N. Dalimov, M. B. Gafurov, F. G. Kamaev, and A. A. Abduvakhabov, Khim. Prir. Soedin., No. 4, 561 (1987)

  8. G. L. Ellman, R. D. Courtney, V. Anders, and K. M. Featherstone, Biochem. Pharmacol., 88 (1961).

  9. A. Cornish-Bowden, Principles of Enzyme Kinetics, Butterworth, London (1976).

    Google Scholar 

Download references

Authors
  1. D. N. Dalimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. B. Gafurov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Z. Tilyabaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. G. Kamaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. A. Abdugakhabov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Fax 627071. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 70–74, January–February, 1994.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dalimov, D.N., Gafurov, M.B., Tilyabaev, Z. et al. Methylphosphonothionates of N-(β-hydroxypropyl)anabasine — Synthesis, structure, and sensitivity of cholinesterases to them. Chem Nat Compd 30, 61–64 (1994). https://doi.org/10.1007/BF00638421

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00638421

Keywords

Search

Navigation