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Relationship between the structure and cholinergic efficiency of various derivatives of the alkaloid anabasine

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Chemistry of Natural Compounds Aims and scope

Abstract

Results on the study over the last 20 years of the relationship between the structure of derivatives of the alkaloid anabasine and their cholinotropic activity are generalized.

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References

  1. A. S. Sadykov, Kh. A. Aslanov, A. I. Ishbaev, S. Kh. Nasyrov, and V. P. Zakharov, “Prospects for the creation of new effective drugs from the alkaloids ofAnabasis aphylla L.,” in: Abstracts of Lectures at an All-Union Scientific and Technical Conference on Methods of Raising the Efficiency of Production and Improving the Quality of Phytochemical Preparations [in Russian], Moscow (1978), p. 42.

  2. Kh. A. Aslanov, K. A. Toremuratov, A. A. Abduvakhabov, S. Z. Mukhamedzhanov, and A. S. Sadykov, Zh. Obshch. Khim,42, No. 10, 2293 (1972).

    Google Scholar 

  3. M. Karimov, A. S. Sadykov, Kh. A. Aslanov, V. B. Leontev, F. G. Kamaev, and T. K. Yunusov, Khim. Prir. Soedin., No. 2, 207 (1972).

  4. A. A. Abduvakhabov, A. S. Sadykov, D. N. Dalimov, and Kh. A. Aslanov, Alkaloids and their Derivatives as Tools for the Study of Cholinergic Systems [in Russian], Fan, Tashkent (1984).

    Google Scholar 

  5. D. A. Inoyatova, “The Chichibabin reaction with some dipyridyls. A novelty in the chemistry of nitrogen-containing heterocycles,” in: Abstracts of Lectures at the IInd All-Union Conference on the Chemistry of Heterocyclic Compounds [in Russian], Riga, Vol. 2 (1979), p. 90.

  6. M. Karimov, M. G. Levkovich, V. B. Leont'ev, A. S. Sadykov, Kh. A. Aslanov, and A. A. Sadykov, Khim. Prir. Soedin., No. 4, 486 (1974).

  7. A. A. Abduvakhabov, Kh. A. Aslanov, and A. S. Sadykov, Dokl. Akad. Nauk UzSSR, No. 4, 340 (1976).

  8. A. I. Ishbaev, Kh. A. Aslanov, Kh. Khaitbaev, M. M. Kurbanova, and T. Otargaliev, Khim.-Farm. Zh., No. 12, 95 (1980).

  9. A. A. Abduvakhabov, O. Kh. Kholbekov, S. A. Auelbekov, and N. N. Godovikov, Izv. Akad. Nauk SSSR, Ser. Khim., No. 11, 2606 (1981).

  10. S. Kh. Nasyrov, V. P. Rabchenko, F. R. Khalikova, I. S. Khazbievich, and É. K. Kashkova, Khim.-Farm. Zh.,12, No. 2, 59 (1978).

    Google Scholar 

  11. S. Kh. Nasyrov and I. S. Khazbievich, The Pharmacology of the Alkaloids ofAnabasis aphylla L. and the Clinical Use of Anabasine Hydrochloride [in Russian], Tashkent (1982).

  12. Yu. R. Khakimov, Synthesis of Esters from Alkaloid Derivatives with Carboxylic Acids and Investigation of their Interaction with Cholinesterases [in Russian], Author's abstract of dissertation ... Doctor of Chemical Sciences, Leningrad (1979).

  13. Yu. R. Khakimov, E. B. Maizel, E. V. Rozengart, A. A. Abduvakhabov, A. S. Sadykov, and Kh. A. Aslanov, Dokl. Akad. Nauk UzSSR, No. 1, 45 (1978).

  14. A. A. Sadykov, The Structure and Function of Cholinergically Active Substances and Natural Neurotoxins [in Russian], Author's abstract of dissertation ... Doctor of Chemical Sciences, Tashknt (1990).

  15. L. A. Srybnaya, Z. Tilyabaeva, A. A. Sadykov, and D. N. Dalimov, Khim. Prir. Soedin., No. 3, 413 (1990).

  16. A. G. Dobren'kov, Z. Tilyabaev, D. N. Dalimov, and A. A. Abduvakhabov, Khim. Prir. Soedin., No. 1, 97 (1988).

  17. A. P. Brestkin, T. N. Vinyar, and E. V. Rozengart, Biokhimiya,46, No. 6, 1042 (1981).

    Google Scholar 

  18. T. N. Vinyar, Interaction of Quaternary Ammonium Compounds with the Cholinesterase and Nicotinic Cholinoreceptors of One and the Same Animal [in Russian], Author's abstract of dissertation ... Candidate of Biological Sciences, Leningrad (1986).

  19. N. N. Kovalev, Properties of the Cholinesterase of the Komandorskii Squid from Different Parts of its Living Area [in Russian], Author's abstract of dissertation ... Candidate of Biological sciences, Leningrad (1990).

  20. A. P. Brestkin, T. N. Vinyar, and E. V. Rozengart, Neirokhimiya, No. 1, 28 (1992).

  21. A. F. Danilov, T. N. Vinyar, V. V. Lavrent'eva, and E. V. Rozengart, Zh. Évol. Biokhim. Fiziol.,21, No. 2, 139 (1985).

    Google Scholar 

  22. A. S. Sadykov, Chemistry of the Alkaloids ofAnabasis aphylla L. [in Russian], Izd-vo Akad. Nauk UzSSR, Tashkent (1956).

    Google Scholar 

  23. N. N. Bogdanova-Kat'kova, Anabasine. A Brief Summary of the Scientific Research Work of VIZR [All-Union Scientific-Research Institute of Plant Protection] for 1935 [in Russian], Leningrad (1935), p. 46.

  24. S. N. Moralev, E. B. Maizel', and Yu. R. Khakimov, Byul VIZR, No. 49 (1980), p. 33.

  25. P. V. Popov, Handbook of Toxic Chemicals [in Russian], Moscow (1981).

  26. R. D. O'Brien, Toxic Phosphorus Esters, Pergamon, Oxford (1960).

    Google Scholar 

  27. I. N. Sazonova, K. V. Novozhilov, I. L. Brik, and N. A. Andreeva, Biokhimiya,37, No. 3, 579 (1972).

    Google Scholar 

  28. D. A. Kharkevich, The Pharmacology of Curaremimetic Substances [in Russian], Meditsna, Moscow (1969).

    Google Scholar 

  29. J. P. Long, Handbuch Exp. Pharmacol.,5, 374 (1963).

    Google Scholar 

  30. L. S. Arutyunyan, A. S. Tsatinyan, O. M. Avokyan, S. G. Karagezyan, and V. G. Sarodyan, Arm. Khim. Zh.,25, No. 1, 78 (1972).

    Google Scholar 

  31. V. U. Rakhmatulina, A. A. Abduvakhabov, and Kh. A. Aslanov, Zh. Obshch. Khim.,48, No. 3, 689 (1978).

    Google Scholar 

  32. A. A. Abduvakhabov, Kh. A. Aslanov, N. N. Godovikov, M. I. Kabachnik, A. S. Sadykov, and V. U. Rakhmatulina, Izv. Akad. Nauk SSSR, Ser. Khim., No. 4, 945 (1972).

  33. K. M. Zuparova, Yu. R. Khakimov, D. N. Isroilov, and E. V. Rozengart, Dokl. Akad Nauk UzSSR, No. 9, 43 (1989).

  34. N. Ya. Lukomskaya, E. V. Rozengart, A. E. Khovanskikh, A. A. Abduvakhabov, K. M. Zuparova, Yu. R. Khakimov, and D. I. Isroilov, Khim.-Farm. Zh., No. 7, 48 (1990).

  35. K. M. Zuparova, Yu. R. Khakimov, and D. I. Isroilov, and E. V. Rozengart, Uzb. Khim. Zh, No. 2, 121 (1990).

  36. A. S. Sadykov, E. V. Rozengart, A. A. Abduvakhabov, and Kh. A. Aslanov, Cholinesterases: Active Center and Action Mechanism [in Russian], Tashkent (1976).

  37. É. B. Zemal' and R. S. Rybalovlev, The Physiological Role of Acetylcholine and the Search for New Drugs [in Russian], Meditsina, Leningrad (1957), p. 338.

    Google Scholar 

  38. The Synthesis of Physiologically Active Compounds [in Russian], Iz-vo Arm. SSR, Erevan (1980).

  39. R. Metcalf, Byull. VOZ, [(Russian) Bulletin of the WHO],44, No. 1, 3 (1972).

    Google Scholar 

  40. W. N. Aldridge, Byull. VOZ, [(Russian) Bulletin of the WHO], No. 3, 23 (1972).

  41. S. A. Roslavtseva and T. A. Pereguda, “The mechanism of the action of insectoacaricides and the mechanism of resistance to them,” in: Advances in Science. Entomology Series [in Russian], Moscow, Vol. 8 (1988), p. 7.

  42. D. T. Karimov, D. N. Dalimov, Z. Tilyabaev, and A. A. Abduvakhabov, “The action of N-methyl- and N-phenylcarbamates incorporating alkaloids and heterocyclic compounds on the catalytic properties of cholinesterases,” in: Abstracts of Lectures at the Ist Conference of the Biochemists of Uzbekistan [in Russian], Tashkent, Novemebr 17–18 (1986), p. 52.

  43. M. B. Gafurov, Uzb. Khim. Zh., No. 5, 15 (1988).

  44. D. N. Dalimov, D. T. Karimov, G. M. Vaizburg, A. A. Abduvakhabov, L. K. Abdullaev, and F. G. Kamaev, Khim. Prir. Soedin., No. 6, 825 (1988).

  45. D. N. Dalimov, Z. Tilyabaev, G. M. Vaizburg, M. B. Gafurov, B. N. Babaev, L. K. Abdullaev, D. T. Karimov, and F. G. Kamaev, “Carbamoylated and phosphorylated alkaloids — synthesis, structure, and interaction with cholinesterases,” in: Abstracts of Lectures at the XIVth Mendeleev Congress of General and Applied Chemistry [in Russian], Moscow, Vol.1 (1988), p. 428.

  46. D. N. Dalimov and M. B. Gafurov, “The synthesis and interaction with cholinesterases of some methylcarbamates and methylphosphonates,” in: All-Union Seminar on the Chemistry of Physiologically Active Compounds: Abstracts of Lectures [in Russian], Chernogolovka (1989), p. 92.

  47. D. N. Dalimov, A. A. Abduvakhabov, Kh. A. Aslanov, A. S. Sadykov, S. S. Mikhailov, I. G. Shcherbak, and N. N. Godovikov, Dokl. Akad. Nauk SSSR,243, 240 (1978).

    Google Scholar 

  48. D. T. Karimov, D. N. Dalimov, and A. A. Abduvakhabov, Zh. Obshch. Khim.,53, No. 5, 1181 (1953).

    Google Scholar 

  49. D. N. Dalimov, M. B. Gafurov, F. G. Kamaev, and A. A. Abduvakhabov, Khim. Prir. Soedin., No. 4, 561 (1987).

  50. N. N. Godovikov, A. A. Abduvakhabov, S. A. Auelbekov, Kh. A. Aslanov, M. I. Kabachnik, and A. S. Sadykov, Zh. Obshch. Khim.,44, 687 (1974).

    Google Scholar 

  51. Kh. Kh. Kushiev, D. N. Dalimov, B. N. Babaev, and A. A. Abduvakhabov, “The anticholinesterase activity of a number of alkyl phenylphosphonates,” in: The Structure and Function of Natural and Physiologically Active Compounds [in Russian], Nukus, No. 2 (1992), p. 31.

  52. A. M. Gazaliev, M. Zh. Zhurinov, Z. Tilyabaev, D. N. Dalimov, K. D. Mukanova, and S. A. Dyusembaev, Khim. Prir. Soedin., No. 4, 584 (1989).

  53. A. M. Gazaliev, M. Zh. Zhurinov, Z. Tilyabaev, and D. N. Dalimov, “Synthesis and cholinergic and pesticidal activities of β-pyridylpyridine derivatives,” in: Abstracts of Lectures at an All-Union Conference on the Chemistry and Technology of Pyridine-containing Pesticides [in Russian], Chernogolovka (1989), p. 63.

  54. A. M. Gazaliev, K. D. Rakhimov, S. A. Dyusembaev, and M. Zh. Zhurinov, “The Electrochenical Synthesis of Diisopropyl N-(β-Pyridylpiperidino)phosphoramidate,” in: Absrracts of Lectures at an All-Union Seminar on the Chemistry of Physiologically Active Compounds [in Russian], Chernogolovka (1989), p. 41.

  55. A. M. Gazaliev, M. Zh. Zhurinov, S. A. Dyusembaev, A. A. Abduvakhabov, D. N. Dalimov, and Z. Tilyabaev, “The electrochemical modification of the alkaloid anabasine,” in: Abstracts of Lectures at the XIIth All-Union Conference on the Electrochemistry of Organic Compounds [in Russian], Moscow (1990), p. 41.

  56. A. M. Gazaliev, M. Zh. Zhurinov, and S. D. Fazylov, Khim. Prir. Soedin., No. 2, 251 (1991).

  57. A. M. Gazaliev, M. Zh. Zhurinov, and S. A. Dyusembaev, Khim. Prir. Soedin., No. 4, 500 (1990).

  58. D. N. Dalimov, S. N. Moralev, B. N. Babaev, B. N. Kormilitsin, N. K. Prokhorenko, A. A. Abduvakhabov, and F. G. Kamaev, Khim. Prir. Soedin., No. 6, 824 (1991).

  59. A. M. Gazaliev, M. Z. Zhurinov, S. D. Fasylov [Fazylov], O. A. Nurkenov, and S. A. Dusembaev [Dyusembaev], “Electronical structure and reactivity of aromatic sequence,” in: Second World Congress of Theoretical Organic Chemistry, WATOC—Toronto, Canada (1990, p. 15.

  60. A. P. Brestkin, A. E. Khovanskikh, nd B. N. Kormilitsyn, “Comparative investigation of interaction of some hydrophobic organophosphorus inhibitors with cholinesterases of spring grain aphid and warm-blooded animals,” in: 36th OHOLO Confeence, Israel (1992).

  61. K. D. Mukanova, E. B. Maizel, and A. M. Gazaliev, “Polyfunctional inhibitors of cytochrome P-450 system with simultaneous effect on glutathione S-transferase and cholinesterases,” in: 7th International Conference of Cytochrome P-450, Moscow (1991), p. 102.

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Authors
  1. Z. Tilyabaev
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  2. D. N. Dalimov
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  3. Kh. Kh. Kushiev
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  4. M. B. Gafurov
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  5. A. A. Abduvakhabov
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Additional information

A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 19–33, January–February, 1994.

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Tilyabaev, Z., Dalimov, D.N., Kushiev, K.K. et al. Relationship between the structure and cholinergic efficiency of various derivatives of the alkaloid anabasine. Chem Nat Compd 30, 15–26 (1994). https://doi.org/10.1007/BF00638412

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