Abstract
Since 1973, we have identified 4 cardiac tumors by ultrasonography in fetal or early postnatal life. Tuberous sclerosis was diagnosed in three infants whose mother was also affected. The first infant died from acute cardiac failure after birth, and the second required cardiac surgery. The third infant had a cardiac tumor and a focal seizure at the age of 8 months. The cardiac tumor disappeared at the age of 2 years. The fourth cardiac rhabdomyoma may be the only sign of tuberous sclerosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chen F, Chu K (1993) An infant with rhabdomyoma prenatally diagnosed in a mother with tuberous sclerosis. J Formos Med Assoc 92:185–187
Cooper D, Schmidtke J (1993) Diagnosis of human genetic disease using recombinant DNA. Hum Genet 92:211–236
Corno A, de Simone G, Catena G, Marcelletti C (1984) Cardiac rhabdomyoma: surgical treatment in the neonate. J Thorac Cardiovasc Surg 87:725–731
Crawford D, Garrett C, Tynan M, Neville G, Allan L (1983) Cardiac rhabdomyomata as a marker for the antenatal detection of tuberous sclerosis. J Med Genet 20:303–312
DiLollo L, Castellani R, Maiorana A (1984) Ultrasonic patterns of a cardiac rhabdomyomas detected in utero. J Perinat Med 12:824–827
Fryer A, Chalmers A, Connor J, Fraser I, Povey S, Yates A, Yates J, Osborne J (1987) Evidence that the gene for tuberous sclerosis is on chromosome 9. Lanset 1:659–660
Gava G, Buoso G, Beltrame G, Memo L, Visentin S, Cavarzerani A (1990) Cardiac rhabdomyoma as a marker for the prenatal detection of tuberous sclerosis. Case report. Br J Obstet Gynecol 97:1154–1157
Geeter D, Kretz J, Nisand I, Eisenmann B, Kieny M-T, Kiney R (1983) Intrapericardial teratoma in a newborn infant: use of fetal echocardiography. Ann Thorac Surg 35:664–666
Groves A, Fragg N, Cook A, Allan L (1992) Cardiac tumors in intrauterine life. Arch Dis Child 67:1189–1192
Harding C, Pagon R (1992) Incidence of Tuberous Sclerosis in Patients With Cardiac Rhabdomyoma. Am J Med Genet 37:443–446
Hunt A, Lindenbaum R (1984) Tuberous sclerosis: a new estimate of prevalence within the Oxford region J Med Genet 21:272–277
McAllister H, Fenoglio J (1978) Tumours of the cardiovascular system. Atlas of tumor pathology, second series. Washington DC, Armed Forces Institute of Pathology
Nadas AS, Ellison RC (1968) Cardiac tumors in infancy. Am J Cardiol 21:363–366
Pesonen E, Leijala M, Jarvenpaa A-L, Terano K (1985) Cardiac rhabdomyomas in a newborn baby. Acta Pediatr Scand 74:824–827
Petrikovsky B, Vintzileos A, Cassidy S, Egan J (1990) Tuberous Sclerosis in Pregnancy. Am J Perinatol 7:133–135
Pomerance A, Davies M (1975) The pathology of the heart. Oxford, Blackwell
Smith H, Watson G, Patel R, Super M (1989) Cardiac rhabdomyomata in tuberous sclerosis: their course and diagnostic value. Arch Dis Child 64:196–200
Smith M, Simpson N (1988) Report of the committee on the genetic constitution of chromosomes 9 and 10. Cytogenet Cell Genet 49:71–78
Stijins M, Linteermans J, Trmournoux M, Vliers A (1982) Spontaneous disappearance of aortic subvalvular obstruction in infants with tuberous sclerosis. Pediatr Cardiol 3:88–89
Wallace G, Smith H, Watson G, Rimmer S, D'souza S (1990) Tuberous sclerosis presenting with fetal and neonatal cardiac tumours. Arch Dis Child 65:377–379
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Komori, S., Bessho, T., Fukuda, H. et al. A report on the perinatal diagnosis of 4 cases of cardiac tumors. Arch Gynecol Obstet 256, 213–218 (1995). https://doi.org/10.1007/BF00634495
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00634495