Skip to main content

Liver

  • Chapter
  • First Online:
Pediatric Ultrasound

Abstract

A wide spectrum of disorders can affect the pediatric liver. This chapter will focus on the role of ultrasound in the diagnosis and management of pediatric hepatic disorders, including a review of transducer selection and imaging techniques, liver development and anatomy, and an overview of the most clinically relevant anatomical variants, congenital anomalies, as well as benign and malignant hepatic disorders encountered in daily practice. Ultrasound imaging of liver transplantation is also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

2D SWE:

Two-dimensional shear-wave elastography

ADPKD:

Autosomal dominant polycystic kidney disease

AFP:

Alpha-fetoprotein

AML:

Acute myeloid leukemia

ARFI:

Acoustic radiation force impulse

BCS:

Budd–Chiari syndrome

CEUS:

Contrast-enhanced ultrasound

CH:

Congenital hemangioma

CMV:

Cytomegalovirus

CT:

Computed tomography

CVP:

Central venous pressure

DWI:

Diffusion-weighted imaging

EBV:

Epstein–Barr virus

e-FAST:

Extended focused assessment with sonography in trauma

EHE:

Epithelioid hemangioendothelioma

ERCP:

Endoscopic retrograde cholangiopancreatography

FALD:

Fontan-associated liver disease

FDG:

Fluorodeoxyglucose

FLHCC:

Fibrolamellar variant of HCC

FNH:

Focal nodular hyperplasia

GLUT-1:

Glucose transporter protein-1

HBV:

Hepatitis B virus

HCC:

Hepatocellular carcinoma

HCV:

Hepatitis C virus

HIDA:

Hepatobiliary iminodiacetic acid

HIV:

Human immunodeficiency virus

HMH:

Hepatic mesenchymal hamartoma

HSCT:

Hematopoietic stem cell transplantation

HSV:

Herpes simplex virus

HU:

Hounsfield unit

IHH:

Infantile hepatic hemangioma

IVC:

Inferior vena cava

IQR:

Interquartile range

MRCP:

MR cholangiopancreatography

MRE:

MR elastography

MR:

Magnetic resonance

NAFLD:

Nonalcoholic fatty liver disease

NASH:

Nonalcoholic steatohepatitis

NHL:

Non-Hodgkin lymphoma

NICH:

Noninvoluting congenital hemangioma

PET:

Positron emission tomography

PHL:

Primary hepatic lymphoma

PICH:

Partially involuting congenital hemangioma

PLD:

Polycystic liver disease

PRETEXT:

Pretreatment extent of tumor

pSWE:

Point shear-wave elastography

PTLD:

Posttransplant lymphoproliferative disorder

RI:

Resistive index

RICH:

Rapidly involuting congenital hemangioma

ROI:

Region of interest

SHL:

Secondary hepatic lymphoma

SOS:

Sinusoidal obstruction syndrome

TACE:

Transarterial chemoembolization

TE:

Transient elastography

TE:

Echo time

TIPS:

Transjugular intrahepatic portosystemic shunt

TPN:

Total parenteral nutrition

UES:

Undifferentiated embryonal sarcoma

UVC:

Umbilical vein catheter

VOD:

Veno-occlusive disease

References

  1. Shamir SB, Kurian J, Kogan-Liberman D, Taragin BH. Hepatic imaging in neonates and young infants: state of the art. Radiology. 2017;285(3):763–77.

    Article  PubMed  Google Scholar 

  2. Patel NJ, Caserta MP, DiSantis DJ. The “starry sky” liver. Abdom Radiol (NY). 2017;42(1):328–9.

    Article  Google Scholar 

  3. Anupindi SA, Biko DM, Ntoulia A, Poznick L, Morgan TA, Darge K, et al. Contrast-enhanced US assessment of focal liver lesions in children. Radiographics. 2017;37(6):1632–47.

    Article  PubMed  Google Scholar 

  4. Greis C. Technology overview: SonoVue (Bracco, Milan). Eur Radiol. 2004;14(Suppl 8):P11–5.

    PubMed  Google Scholar 

  5. Qin S, Caskey CF, Ferrara KW. Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering. Phys Med Biol. 2009;54(6):R27–57.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Jacob J, Deganello A, Sellars ME, Hadzic N, Sidhu PS. Contrast enhanced ultrasound (CEUS) characterization of grey-scale sonographic indeterminate focal liver lesions in pediatric practice. Ultraschall Med. 2013;34(6):529–40.

    Article  CAS  PubMed  Google Scholar 

  7. Rafailidis V, Deganello A, Watson T, Sidhu PS, Sellars ME. Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications. Br J Radiol. 2017;90(1069):​20160556.

    Article  PubMed  Google Scholar 

  8. El-Ali AM, Davis JC, Cickelli JM, Squires JH. Contrast-enhanced ultrasound of liver lesions in children. Pediatr Radiol. 2019;49(11):1422–32.

    Article  PubMed  Google Scholar 

  9. Bhayana D, Kim TK, Jang HJ, Burns PN, Wilson SR. Hypervascular liver masses on contrast-enhanced ultrasound: the importance of washout. AJR Am J Roentgenol. 2010;194(4):977–83.

    Article  PubMed  Google Scholar 

  10. Darge K, Papadopoulou F, Ntoulia A, Bulas DI, Coley BD, Fordham LA, et al. Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS). Pediatr Radiol. 2013;43(9):1063–73.

    Article  PubMed  Google Scholar 

  11. Yusuf GT, Sellars ME, Deganello A, Cosgrove DO, Sidhu PS. Retrospective analysis of the safety and cost implications of pediatric contrast-enhanced ultrasound at a single center. AJR Am J Roentgenol. 2017;208(2):446–52.

    Article  PubMed  Google Scholar 

  12. Coleman JL, Navid F, Furman WL, McCarville MB. Safety of ultrasound contrast agents in the pediatric oncologic population: a single-institution experience. AJR Am J Roentgenol. 2014;202(5):​966–70.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Tang C, Fang K, Guo Y, Li R, Fan X, Chen P, et al. Safety of sulfur hexafluoride microbubbles in sonography of abdominal and superficial organs: retrospective analysis of 30,222 cases. J Ultrasound Med. 2017;36(3):531–8.

    Article  PubMed  Google Scholar 

  14. Cantisani V, Grazhdani H, Fioravanti C, Rosignuolo M, Calliada F, Messineo D, et al. Liver metastases: contrast-enhanced ultrasound compared with computed tomography and magnetic resonance. World J Gastroenterol. 2014;20(29):9998–10007.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Rosado E, Riccabona M. Off-label use of ultrasound contrast agents for intravenous applications in children: analysis of the existing literature. J Ultrasound Med. 2016;35(3):487–96.

    Article  PubMed  Google Scholar 

  16. Simpson DH, Chin CT, Burns PN. Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control. 1999;46(2):372–82.

    Article  CAS  PubMed  Google Scholar 

  17. Lassau N, Bonastre J, Kind M, Vilgrain V, Lacroix J, Cuinet M, et al. Validation of dynamic contrast-enhanced ultrasound in predicting outcomes of antiangiogenic therapy for solid tumors: the French multicenter support for innovative and expensive techniques study. Investig Radiol. 2014;49(12):794–800.

    Article  CAS  Google Scholar 

  18. Barr RG, Ferraioli G, Palmeri ML, Goodman ZD, Garcia-Tsao G, Rubin J, et al. Elastography assessment of liver fibrosis: Society of Radiologists in ultrasound consensus conference statement. Radiology. 2015;276(3):845–61.

    Article  PubMed  Google Scholar 

  19. Stenzel M, Mentzel HJ. Ultrasound elastography and contrast-enhanced ultrasound in infants, children and adolescents. Eur J Radiol. 2014;83(9):1560–9.

    Article  PubMed  Google Scholar 

  20. Behrens CB, Langholz JH, Eiler J, Jenewein R, Naehrlich L, Fuchs K, et al. A pilot study of the characterization of hepatic tissue strain in children with cystic-fibrosis-associated liver disease (CFLD) by acoustic radiation force impulse imaging. Pediatr Radiol. 2013;43(5):552–7.

    Article  PubMed  Google Scholar 

  21. Noruegas MJ, Matos H, Goncalves I, Cipriano MA, Sanches C. Acoustic radiation force impulse-imaging in the assessment of liver fibrosis in children. Pediatr Radiol. 2012;42(2):201–4.

    Article  PubMed  Google Scholar 

  22. Leschied JR, Dillman JR, Bilhartz J, Heider A, Smith EA, Lopez MJ. Shear wave elastography helps differentiate biliary atresia from other neonatal/infantile liver diseases. Pediatr Radiol. 2015;45(3):366–75.

    Article  PubMed  Google Scholar 

  23. DiPaola FW, Schumacher KR, Goldberg CS, Friedland-Little J, Parameswaran A, Dillman JR. Effect of Fontan operation on liver stiffness in children with single ventricle physiology. Eur Radiol. 2017;27(6):2434–42.

    Article  PubMed  Google Scholar 

  24. Kennedy P, Wagner M, Castera L, Hong CW, Johnson CL, Sirlin CB, et al. Quantitative elastography methods in liver disease: current evidence and future directions. Radiology. 2018;286(3):​738–63.

    Google Scholar 

  25. MacParland SA, Liu JC, Ma XZ, Innes BT, Bartczak AM, Gage BK, et al. Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations. Nat Commun. 2018;9(1):4383.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Soyer P. Segmental anatomy of the liver: utility of a nomenclature accepted worldwide. AJR Am J Roentgenol. 1993;161(3):572–3.

    Article  CAS  PubMed  Google Scholar 

  27. Albers BK, Khanna G. Vascular anomalies of the pediatric liver. Radiographics. 2019;39(3):842–56.

    Article  PubMed  Google Scholar 

  28. Riahinezhad M, Rezaei M, Saneian H, Famouri F, Farghadani M. Doppler assessment of children with liver cirrhosis and portal hypertension in comparison with a healthy control group: an analytical cross-sectional study. J Res Med Sci. 2018;23:40.

    Article  PubMed  PubMed Central  Google Scholar 

  29. McNaughton DA, Abu-Yousef MM. Doppler US of the liver made simple. Radiographics. 2011;31(1):161–88.

    Article  PubMed  Google Scholar 

  30. Allan M, Asimakidou M, Davenport M. Antenatally-detected liver cysts: causes and characteristics, indications for intervention. J Pediatr Surg. 2020;55(3):441–5.

    Google Scholar 

  31. Linden AF, Pulcrano ME, Duffy BJ, Lange PA, Tsung DY, Hartman GE, et al. Laparoscopic excision of congenital hepatic cysts in the pediatric population: a case series and literature review. J Laparoendosc Adv Surg Tech A. 2016;26(6):493–7.

    Article  PubMed  Google Scholar 

  32. Bergmann C. Educational paper: ciliopathies. Eur J Pediatr. 2012;171(9):1285–300.

    Article  PubMed  Google Scholar 

  33. Gunay-Aygun M. Liver and kidney disease in ciliopathies. Am J Med Genet Part C Semin Med Genet. 2009;151C(4):296–306.

    Google Scholar 

  34. Gabow PA, Johnson AM, Kaehny WD, Manco-Johnson ML, Duley IT, Everson GT. Risk factors for the development of hepatic cysts in autosomal dominant polycystic kidney disease. Hepatology. 1990;11(6):1033–7.

    Article  CAS  PubMed  Google Scholar 

  35. Gupta S, Seith A, Dhiman RK, Chawla YK, Sud K, Kohli HS, et al. CT of liver cysts in patients with autosomal dominant polycystic kidney disease. Acta Radiol. 1999;40(4):444–8.

    Article  CAS  PubMed  Google Scholar 

  36. Caroli A, Antiga L, Cafaro M, Fasolini G, Remuzzi A, Remuzzi G, et al. Reducing polycystic liver volume in ADPKD: effects of somatostatin analogue octreotide. Clin J Am Soc Nephrol. 2010;5(5):783–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. van Aerts RMM, van de Laarschot LFM, Banales JM, Drenth JPH. Clinical management of polycystic liver disease. J Hepatol. 2018;68(4):827–37.

    Article  PubMed  Google Scholar 

  38. Howard ER, Davenport M. Congenital extrahepatic portocaval shunts—the Abernethy malformation. J Pediatr Surg. 1997;32(3):494–7.

    Article  CAS  PubMed  Google Scholar 

  39. Uppal V, Mansoor S, Furuya KN. Pediatric non-alcoholic fatty liver disease. Curr Gastroenterol Rep. 2016;18(5):24.

    Article  PubMed  Google Scholar 

  40. Nobili V, Alkhouri N, Alisi A, Della Corte C, Fitzpatrick E, Raponi M, et al. Nonalcoholic fatty liver disease: a challenge for pediatricians. JAMA Pediatr. 2015;169(2):170–6.

    Article  PubMed  Google Scholar 

  41. Schwimmer JB, Middleton MS, Behling C, Newton KP, Awai HI, Paiz MN, et al. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease. Hepatology. 2015;61(6):1887–95.

    Article  CAS  PubMed  Google Scholar 

  42. Lurie Y, Webb M, Cytter-Kuint R, Shteingart S, Lederkremer GZ. Non-invasive diagnosis of liver fibrosis and cirrhosis. World J Gastroenterol. 2015;21(41):11567–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Gilligan LA, Trout AT, Bennett P, Dillman JR. Repeatability and agreement of shear wave speed measurements in phantoms and human livers across 6 ultrasound 2-dimensional shear wave elastography systems. Investig Radiol. 55(4):191–9.

    Google Scholar 

  44. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J. 2008;411(1):1–18.

    Article  PubMed  Google Scholar 

  45. Pinto RB, Schneider AC, da Silveira TR. Cirrhosis in children and adolescents: an overview. World J Hepatol. 2015;7(3):​392–405.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Huber A, Ebner L, Heverhagen JT, Christe A. State-of-the-art imaging of liver fibrosis and cirrhosis: a comprehensive review of current applications and future perspectives. Eur J Radiol Open. 2015;2:90–100.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Ito K, Mitchell DG, Kim MJ, Awaya H, Koike S, Matsunaga N. Right posterior hepatic notch sign: a simple diagnostic MR finding of cirrhosis. J Magn Reson Imaging. 2003;18(5):561–6.

    Article  PubMed  Google Scholar 

  48. Ito K, Mitchell DG, Gabata T, Hussain SM. Expanded gallbladder fossa: simple MR imaging sign of cirrhosis. Radiology. 1999;​211(3):723–6.

    Article  CAS  PubMed  Google Scholar 

  49. Faria SC, Ganesan K, Mwangi I, Shiehmorteza M, Viamonte B, Mazhar S, et al. MR imaging of liver fibrosis: current state of the art. Radiographics. 2009;29(6):1615–35.

    Article  PubMed  Google Scholar 

  50. Roberts EA. Neonatal hepatitis syndrome. Semin Neonatol. 2003;8(5):357–74.

    Article  PubMed  Google Scholar 

  51. Mortelé KJ, Segatto E, Ros PR. The infected liver: radiologic-pathologic correlation. Radiographics. 2004;24(4):937–55.

    Article  PubMed  Google Scholar 

  52. McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology. 2009;49(5 Suppl):S45–55.

    Article  CAS  PubMed  Google Scholar 

  53. Fattovich G, Bortolotti F, Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol. 2008;48(2):335–52.

    Article  PubMed  Google Scholar 

  54. Mortele KJ, Ros PR. Imaging of diffuse liver disease. Semin Liver Dis. 2001;21(2):195–212.

    Article  CAS  PubMed  Google Scholar 

  55. Mortele KJ, Segatto E, Ros PR. The infected liver: radiologic-pathologic correlation. Radiographics. 2004;24(4):937–55.

    Article  PubMed  Google Scholar 

  56. Chang MH, You SL, Chen CJ, Liu CJ, Lee CM, Lin SM, et al. Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study. J Natl Cancer Inst. 2009;101(19):​1348–55.

    Article  CAS  PubMed  Google Scholar 

  57. Wisplinghoff H, Appleton DL. Bacterial infections of the liver. In: Weber O, Protzer U, editors. Comparative Hepatitis. 1st ed. Birkhäuser Advances in Infectious Diseases. Basel. Birkhäuser; 2008.

    Google Scholar 

  58. Beckingham IJ, Krige JE. ABC of diseases of liver, pancreas, and biliary system: liver and pancreatic trauma. BMJ. 2001;322(7289):​783–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Bächler P, Baladron MJ, Menias C, Beddings I, Loch R, Zalaquett E, et al. Multimodality imaging of liver infections: differential diagnosis and potential pitfalls. Radiographics. 2016;36(4):1001–23.

    Article  PubMed  Google Scholar 

  60. Fernandez J, Acevedo J, Wiest R, Gustot T, Amoros A, Deulofeu C, et al. Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis. Gut. 2018;67(10):1870–80.

    Article  CAS  PubMed  Google Scholar 

  61. Popescu A, Sporea I, S¸irli R, Dănilă M, Mare R, Tas¸cău OG, et al. Does contrast enhanced ultrasound improve the management of liver abscesses? A single centre experience. Med Ultrason. 2015;17(4):​451–5.

    Google Scholar 

  62. Chan J, Tsui E, Luk S, Fung A, Yuen M, Szeto M, et al. Diffusion-​weighted MR imaging of the liver: distinguishing hepatic abscess from cystic or necrotic tumor. Abdom Imaging. 2001;26(2):161–5.

    Google Scholar 

  63. Kim YK, Kim CS, Lee JM, Ko SW, Moon WS, Yu HC. Solid organizing hepatic abscesses mimic hepatic tumor: multiphasic computed tomography and magnetic resonance imaging findings with histopathologic correlation. J Comput Assist Tomogr. 2006;30(2):189–96.

    Article  PubMed  Google Scholar 

  64. Zerem E, Hadzic A. Sonographically guided percutaneous catheter drainage versus needle aspiration in the management of pyogenic liver abscess. AJR Am J Roentgenol. 2007;189(3):W138–42.

    Article  PubMed  Google Scholar 

  65. Calley JL, Warris A. Recognition and diagnosis of invasive fungal infections in neonates. J Infect. 2017;74(Suppl 1):S108–13.

    Google Scholar 

  66. Alexander BD, Pfaller MA. Contemporary tools for the diagnosis and management of invasive mycoses. Clin Infect Dis. 2006;43(Supplement_1):S15–27.

    Article  CAS  Google Scholar 

  67. Katragkou A, Fisher BT, Groll AH, Roilides E, Walsh TJ. Diagnostic imaging and invasive fungal diseases in children. J Pediatr Infect Dis Soc. 2017;6(suppl_1):S22–31.

    Google Scholar 

  68. Bachler P, Baladron MJ, Menias C, Beddings I, Loch R, Zalaquett E, et al. Multimodality imaging of liver infections: differential diagnosis and potential pitfalls. Radiographics. 2016;36(4):​1001–23.

    Article  PubMed  Google Scholar 

  69. Chen K, Wang Q, Pleasants RA, Ge L, Liu W, Peng K, et al. Empiric treatment against invasive fungal diseases in febrile neutropenic patients: a systematic review and network meta-analysis. BMC Infect Dis. 2017;17(1):159.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Rodriguez Carnero P, Hernandez Mateo P, Martin-Garre S, Garcia Perez A, Del Campo L. Unexpected hosts: imaging parasitic diseases. Insights Imaging. 2017;8(1):101–25.

    Article  PubMed  Google Scholar 

  71. Stanley SL Jr. Amoebiasis. Lancet. 2003;361(9362):1025–34.

    Article  CAS  PubMed  Google Scholar 

  72. Radin DR, Ralls P, Colletti P, Halls J. CT of amebic liver abscess. AJR Am J Roentgenol. 1988;150(6):1297–301.

    Article  CAS  PubMed  Google Scholar 

  73. Landay MJ, Setiawan H, Hirsch G, Christensen EE, Conrad MR. Hepatic and thoracic amaebiasis. AJR Am J Roentgenol. 1980;135(3):449–54.

    Article  CAS  PubMed  Google Scholar 

  74. Miele V, Piccolo CL, Trinci M, Galluzzo M, Ianniello S, Brunese L. Diagnostic imaging of blunt abdominal trauma in pediatric patients. Radiol Med. 2016;121(5):409–30.

    Article  PubMed  Google Scholar 

  75. Armstrong LB, Mooney DP, Paltiel H, Barnewolt C, Dionigi B, Arbuthnot M, et al. Contrast enhanced ultrasound for the evaluation of blunt pediatric abdominal trauma. J Pediatr Surg. 2018;53(3):548–52.

    Article  PubMed  Google Scholar 

  76. Menichini G, Sessa B, Trinci M, Galluzzo M, Miele V. Accuracy of contrast-enhanced ultrasound (CEUS) in the identification and characterization of traumatic solid organ lesions in children: a retrospective comparison with baseline US and CE-MDCT. Radiol Med. 2015;120(11):989–1001.

    Article  PubMed  Google Scholar 

  77. Trinci M, Piccolo CL, Ferrari R, Galluzzo M, Ianniello S, Miele V. Contrast-enhanced ultrasound (CEUS) in pediatric blunt abdominal trauma. J Ultrasound. 2019;22(1):27–40.

    Article  PubMed  Google Scholar 

  78. Ward J, Alarcon L, Peitzman AB. Management of blunt liver injury: what is new? Eur J Trauma Emerg Surg. 2015;41(3):​229–37.

    Article  CAS  PubMed  Google Scholar 

  79. Durkin N, Deganello A, Sellars ME, Sidhu PS, Davenport M, Makin E. Post-traumatic liver and splenic pseudoaneurysms in children: diagnosis, management, and follow-up screening using contrast enhanced ultrasound (CEUS). J Pediatr Surg. 2016;51(2):289–92.

    Article  PubMed  Google Scholar 

  80. Derinkuyu BE, Boyunaga OL, Damar C, Unal S, Ergenekon E, Alimli AG, et al. Hepatic complications of umbilical venous catheters in the neonatal period: the ultrasound spectrum. J Ultrasound Med. 2018;37(6):1335–44.

    Article  PubMed  Google Scholar 

  81. Selvam S, Humphrey T, Woodley H, English S, Kraft JK. Sonographic features of umbilical catheter-related complications. Pediatr Radiol. 2018;48(13):1964–70.

    Article  PubMed  Google Scholar 

  82. Schlesinger AE, Braverman RM, DiPietro MA. Pictorial essay. Neonates and umbilical venous catheters: normal appearance, anomalous positions, complications, and potential aid to diagnosis. AJR Am J Roentgenol. 2003;180(4):1147–53.

    Article  PubMed  Google Scholar 

  83. Khanna R, Sarin SK. Idiopathic portal hypertension and extrahepatic portal venous obstruction. Hepatol Int. 2018;12(Suppl 1):148–67.

    Article  PubMed  Google Scholar 

  84. Rajesh S, Mukund A, Sureka B, Bansal K, Ronot M, Arora A. Non-cirrhotic portal hypertension: an imaging review. Abdom Radiol (NY). 2018;43(8):1991–2010.

    Article  CAS  PubMed  Google Scholar 

  85. Young V, Rajeswaran S. Management of portal hypertension in the pediatric population: a primer for the interventional radiologist. Semin Intervent Radiol. 2018;35(3):160–4.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Giouleme O, Theocharidou E. Management of portal hypertension in children with portal vein thrombosis. J Pediatr Gastroenterol Nutr. 2013;57(4):419–25.

    Article  CAS  PubMed  Google Scholar 

  87. Bandali MF, Mirakhur A, Lee EW, Ferris MC, Sadler DJ, Gray RR, et al. Portal hypertension: imaging of portosystemic collateral pathways and associated image-guided therapy. World J Gastroenterol. 2017;23(10):1735–46.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Kim DW, Yoon HM, Jung AY, Lee JS, Oh SH, Kim KM, et al. Diagnostic performance of ultrasound elastography for evaluating portal hypertension in children: a systematic review and meta-analysis. J Ultrasound Med. 2019;38(3):747–59.

    Article  PubMed  Google Scholar 

  89. Burak Ozkan M, Bilgici MC, Eren E, Caltepe G. Diagnostic accuracy of point shear wave elastography in the detection of portal hypertension in pediatric patients. Diagn Interv Imaging. 2018;99(3):151–6.

    Article  CAS  PubMed  Google Scholar 

  90. Monroe EJ, Speir EJ, Hawkins CM, Shivaram G, Koo KSH, Gill AE. Transsplenic splenoportography and portal venous interventions in pediatric patients. Pediatr Radiol. 2018;48(10):1441–50.

    Article  PubMed  Google Scholar 

  91. Aydinli M, Bayraktar Y. Budd-Chiari syndrome: etiology, pathogenesis and diagnosis. World J Gastroenterol. 2007;13(19):2693–6.

    Google Scholar 

  92. Ferral H, Behrens G, Lopera J. Budd-Chiari syndrome. AJR Am J Roentgenol. 2012;199(4):737–45.

    Article  PubMed  Google Scholar 

  93. Bansal V, Gupta P, Sinha S, Dhaka N, Kalra N, Vijayvergiya R, et al. Budd-Chiari syndrome: imaging review. Br J Radiol. 2018;91(1092):20180441.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Valla D-C. Budd–Chiari syndrome/hepatic venous outflow tract obstruction. Hepatol Int. 2018;12(1):168–80.

    Article  PubMed  Google Scholar 

  95. Loomes DE, Chang A, Webber D, Scudamore CH, Yoshida EM. Acute Budd-Chiari syndrome. Can J Gastroenterol. 2011;25(6):302–3.

    Google Scholar 

  96. Lu X, Yang C, Xu K, Rong Y, Li S, Li J, et al. Magnetic resonance venography in the diagnosis of inferior vena cava obstruction in Budd-Chiari syndrome. Eur Rev Med Pharmacol Sci. 2015;19(2):256–64.

    Google Scholar 

  97. Faraoun SA, Boudjella Mel A, Debzi N, Benidir N, Afredj N, Guerrache Y, et al. Budd-Chiari syndrome: an update on imaging features. Clin Imaging. 2016;40(4):637–46.

    Article  PubMed  Google Scholar 

  98. Parekh J, Matei VM, Canas-Coto A, Friedman D, Lee WM. Budd-Chiari syndrome causing acute liver failure: A multicenter case series. Liver Transpl. 2017;23(2):135–42.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Xiang H, Han J, Ridley WE, Ridley LJ. Spider's web sign: Budd-Chiari syndrome. J Med Imaging Radiat Oncol. 2018;62(Suppl 1):110.

    Article  PubMed  Google Scholar 

  100. Redkar R, Bangar A, Hathiramani V, Raj V, Swathi C. Pediatric Budd-Chiari syndrome: a case series. Indian Pediatr. 2018;55(10):​871–3.

    Article  PubMed  Google Scholar 

  101. Cura M, Haskal Z, Lopera J. Diagnostic and interventional radiology for Budd-Chiari syndrome. Radiographics. 2009;29(3):​669–81.

    Article  PubMed  Google Scholar 

  102. Coppell JA, Richardson PG, Soiffer R, Martin PL, Kernan NA, Chen A, et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 2010;16(2):157–68.

    Article  PubMed  Google Scholar 

  103. Tewari P, Wallis W, Kebriaei P. Manifestations and management of veno-occlusive disease/sinusoidal obstruction syndrome in the era of contemporary therapies. Clin Adv Hematol Oncol. 2017;15(2):130–9.

    PubMed  Google Scholar 

  104. Zhang Y, Yan Y, Song B. Noninvasive imaging diagnosis of sinusoidal obstruction syndrome: a pictorial review. Insights Imaging. 2019;10(1):110.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation. Bone Marrow Transplant. 2018;53(2):138–45.

    Article  CAS  PubMed  Google Scholar 

  106. Iannaccone R, Federle MP, Brancatelli G, Matsui O, Fishman EK, Narra VR, et al. Peliosis hepatis: spectrum of imaging findings. AJR Am J Roentgenol. 2006;187(1):W43–52.

    Article  PubMed  Google Scholar 

  107. Loizides A, Glodny B, Zoller H, Zelger BG, Junker D, Henninger B, et al. Contrast enhanced ultrasound of a rare case of Peliosis hepatis. Med Ultrason. 2017;19(1):114–6.

    Article  PubMed  Google Scholar 

  108. Terlizzi JP, Azizi R, Chow MD, Underberg-Davis S, Nosher JL, Stafford PW, et al. Peliosis hepatis in a child with myotubular myopathy: successful treatment using hepatic artery embolization. J Pediatr Surg. 2013;48(8):e9–12.

    Article  PubMed  Google Scholar 

  109. Wells ML, Fenstad ER, Poterucha JT, Hough DM, Young PM, Araoz PA, et al. Imaging findings of congestive hepatopathy. Radiographics. 2016;36(4):1024–37.

    Article  PubMed  Google Scholar 

  110. Poterucha JT, Johnson JN, Qureshi MY, O'Leary PW, Kamath PS, Lennon RJ, et al. Magnetic resonance elastography: a novel technique for the detection of hepatic fibrosis and hepatocellular carcinoma after the Fontan operation. Mayo Clin Proc. 2015;90(7):882–94.

    Article  PubMed  Google Scholar 

  111. Komatsu H, Inui A, Kishiki K, Kawai H, Yoshio S, Osawa Y, et al. Liver disease secondary to congenital heart disease in children. Expert Rev Gastroenterol Hepatol. 2019;13(7):651–66.

    Article  CAS  PubMed  Google Scholar 

  112. Hosokawa T, Yamada Y, Tanami Y, Sato Y, Hosokawa M, Oguma E. Predictors of prognosis in children with portal venous gas detected by ultrasound. Med Ultrason. 2019;21(1):30–6.

    Article  PubMed  Google Scholar 

  113. Sebastia C, Quiroga S, Espin E, Boye R, Alvarez-Castells A, Armengol M. Portomesenteric vein gas: pathologic mechanisms, CT findings, and prognosis. Radiographics. 2000;20(5):1213–24.

    Google Scholar 

  114. Abboud B, El Hachem J, Yazbeck T, Doumit C. Hepatic portal venous gas: physiopathology, etiology, prognosis and treatment. World J Gastroenterol. 2009;15(29):3585–90.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Deutsch SA, Christian CW. Pneumatosis intestinalis due to child abuse. Pediatr Emerg Care. 2019;35(2):e32–3.

    Google Scholar 

  116. Varma S, Dumitriu D, Stephenne X, Smets F, Clapuyt P, Sokal E. Pneumatosis intestinalis and portal venous gas in pediatric liver transplant recipient. J Pediatr Gastroenterol Nutr. 2016;62(2):e14.

    Article  PubMed  Google Scholar 

  117. Daniel S, Francis D, Tobin M, Chawla A. Case of hepatic portal venous gas in an infant with hypertrophic pyloric stenosis. BMJ Case Rep. 2018;2018:bcr2018224794.

    Article  PubMed Central  Google Scholar 

  118. Liang KW, Huang HH, Tyan YS, Tsao TF. Hepatic portal venous gas: review of ultrasonographic findings and the use of the “meteor shower” sign to diagnose it. Ultrasound Q. 2018;34(4):268–71.

    Article  PubMed  Google Scholar 

  119. Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, et al. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003;6(6):495–510.

    Article  PubMed  Google Scholar 

  120. Nasseri E, Piram M, McCuaig CC, Kokta V, Dubois J, Powell J. Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol. 2014;70(1):​75–9.

    Article  PubMed  Google Scholar 

  121. Roebuck D, Sebire N, Lehmann E, Barnacle A. Rapidly involuting congenital haemangioma (RICH) of the liver. Pediatr Radiol. 2012;42(3):308–14.

    Article  PubMed  Google Scholar 

  122. Menapace D, Mitkov M, Towbin R, Hogeling M. The changing face of complicated infantile hemangioma treatment. Pediatr Radiol. 2016;46(11):1494–506.

    Article  PubMed  Google Scholar 

  123. Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, et al. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg. 2007;42(1):62–7.

    Google Scholar 

  124. Mulliken JB, Enjolras O. Congenital hemangiomas and infantile hemangioma: missing links. J Am Acad Dermatol. 2004;50(6):​875–82.

    Article  PubMed  Google Scholar 

  125. Quaia E, Calliada F, Bertolotto M, Rossi S, Garioni L, Rosa L, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: diagnostic performance and confidence. Radiology. 2004;232(2):​420–30.

    Article  PubMed  Google Scholar 

  126. Pugmire BS, Towbin AJ. Magnetic resonance imaging of primary pediatric liver tumors. Pediatr Radiol. 2016;46(6):764–77.

    Article  PubMed  Google Scholar 

  127. Chung EM, Cube R, Lewis RB, Conran RM. From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics. 2010;30(3):801–26.

    Article  PubMed  Google Scholar 

  128. Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, et al. Guidance document for hepatic hemangioma (infantile and congenital) evaluation and monitoring. J Pediatr. 2018;203:294–300.e2.

    Article  PubMed  Google Scholar 

  129. Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, et al. Clinical practice guideline for the management of infantile hemangiomas. Pediatrics. 2019;143(1):e20183475.

    Article  PubMed  Google Scholar 

  130. Itinteang T, Withers AH, Davis PF, Tan ST. Biology of infantile hemangioma. Front Surg. 2014;1:38.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ, et al. History of the infantile hepatic hemangioma: from imaging to generating a differential diagnosis. World J Clin Pediatr. 2016;5(3):273–80.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Adeyiga AO, Lee EY, Eisenberg RL. Focal hepatic masses in pediatric patients. AJR Am J Roentgenol. 2012;199(4):W422–40.

    Article  PubMed  Google Scholar 

  133. Simsek E, Demiral M, Gundogdu E. Severe consumptive hypothyroidism caused by multiple infantile hepatic haemangiomas. J Pediatr Endocrinol Metab. 2018;31(7):823–7.

    Article  CAS  PubMed  Google Scholar 

  134. Rialon KL, Murillo R, Fevurly RD, Kulungowski AM, Zurakowski D, Liang M, et al. Impact of screening for hepatic hemangiomas in patients with multiple cutaneous infantile hemangiomas. Pediatr Dermatol. 2015;32(6):808–12.

    Article  PubMed  Google Scholar 

  135. Stringer MD, Alizai NK. Mesenchymal hamartoma of the liver: a systematic review. J Pediatr Surg. 2005;40(11):1681–90.

    Article  PubMed  Google Scholar 

  136. Apellaniz-Ruiz M, Segni M, Kettwig M, Gluer S, Pelletier D, Nguyen VH, et al. Mesenchymal hamartoma of the liver and DICER1 syndrome. N Engl J Med. 2019;380(19):1834–42.

    Article  CAS  PubMed  Google Scholar 

  137. Guillerman RP, Foulkes WD, Priest JR. Imaging of DICER1 syndrome. Pediatr Radiol. 2019;49(11):1488–505.

    Article  PubMed  Google Scholar 

  138. Thampy R, Elsayes KM, Menias CO, Pickhardt PJ, Kang HC, Deshmukh SP, et al. Imaging features of rare mesenychmal liver tumours: beyond haemangiomas. Br J Radiol. 2017;90(1079):​20170373.

    Article  PubMed  PubMed Central  Google Scholar 

  139. Koganti SB, Thumma VM, Nagari B. Mesenchymal hamartoma of the liver: complete excision always necessary. Case Rep Surg. 2017;2017:8314102.

    PubMed  PubMed Central  Google Scholar 

  140. Tsao K, Hirose S, Sydorak R, Goldstein RB, Machin GA, Albanese CT, et al. Fetal therapy for giant hepatic cysts. J Pediatr Surg. 2002;37(10):E31.

    Article  PubMed  Google Scholar 

  141. Horiuchi A, Muraji T, Tsugawa C, Nishijima E, Satho S, Takamizawa S. Laparoscopic fenestration of a neonatally detected hepatic mesenchymal hamartoma. J Laparoendosc Adv Surg Tech A. 2005;15(4):432–4.

    Article  PubMed  Google Scholar 

  142. Citak EC, Karadeniz C, Oguz A, Boyunaga O, Ekinci O, Okur V. Nodular regenerative hyperplasia and focal nodular hyperplasia of the liver mimicking hepatic metastasis in children with solid tumors and a review of literature. Pediatr Hematol Oncol. 2007;24(4):281–9.

    Article  PubMed  Google Scholar 

  143. Masetti R, Colecchia A, Rondelli R, Martoni A, Vendemini F, Biagi C, et al. Benign hepatic nodular lesions after treatment for childhood cancer. J Pediatr Gastroenterol Nutr. 2013;56(2):151–5.

    Article  CAS  PubMed  Google Scholar 

  144. Ronot M, Vilgrain V. Imaging of benign hepatocellular lesions: current concepts and recent updates. Clin Res Hepatol Gastroenterol. 2014;38(6):681–8.

    Article  PubMed  Google Scholar 

  145. Suh CH, Kim KW, Kim GY, Shin YM, Kim PN, Park SH. The diagnostic value of Gd-EOB-DTPA-MRI for the diagnosis of focal nodular hyperplasia: a systematic review and meta-analysis. Eur Radiol. 2015;25(4):950–60.

    Article  PubMed  Google Scholar 

  146. Oliveira C, Gil-Agostinho A, Goncalves I, Noruegas MJ. Transarterial embolisation of a large focal nodular hyperplasia, using microspheres, in a paediatric patient. BMJ Case Rep. 2015;2015:​bcr2014208879.

    Article  PubMed  PubMed Central  Google Scholar 

  147. Agrawal S, Agarwal S, Arnason T, Saini S, Belghiti J. Management of hepatocellular adenoma: recent advances. Clin Gastroenterol Hepatol. 2015;13(7):1221–30.

    Article  PubMed  Google Scholar 

  148. Smolock AR, Cristescu MM, Potretzke TA, Ziemlewicz TJ, Lubner MG, Hinshaw JL, et al. Microwave ablation for the treatment of hepatic adenomas. J Vasc Interv Radiol. 2016;27(2):244–9.

    Article  PubMed  Google Scholar 

  149. Chung EM, Lattin GE Jr, Cube R, Lewis RB, Marichal-Hernandez C, Shawhan R, et al. From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation. Part 2. Malignant tumors. Radiographics. 2011;31(2):483–507.

    Article  PubMed  Google Scholar 

  150. Lopez-Terrada D, Alaggio R, de Davila MT, Czauderna P, Hiyama E, Katzenstein H, et al. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol. 2014;27(3):472–91.

    Article  PubMed  Google Scholar 

  151. Ng K, Mogul DB. Pediatric liver tumors. Clin Liver Dis. 2018;​22(4):753–72.

    Article  PubMed  Google Scholar 

  152. Baheti AD, Chapman T, Rudzinski E, Albert CM, Stanescu AL. Diagnosis, histopathologic correlation and management of hepatoblastoma: what the radiologist needs to know. Clin Imaging. 2018;52:273–9.

    Article  PubMed  Google Scholar 

  153. Spector LG, Puumala SE, Carozza SE, Chow EJ, Fox EE, Horel S, et al. Cancer risk among children with very low birth weights. Pediatrics. 2009;124(1):96–104.

    Article  PubMed  Google Scholar 

  154. Darbari A, Sabin KM, Shapiro CN, Schwarz KB. Epidemiology of primary hepatic malignancies in US children. Hepatology. 2003;38(3):560–6.

    Article  PubMed  Google Scholar 

  155. Towbin AJ, Meyers RL, Woodley H, Miyazaki O, Weldon CB, Morland B, et al. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol. 2018;48(4):536–54.

    Article  PubMed  Google Scholar 

  156. Dachman A, Pakter R, Ros P, Fishman EK, Goodman Z, Lichtenstein J. Hepatoblastoma: radiologic-pathologic correlation in 50 cases. Radiology. 1987;164(1):15–9.

    Article  CAS  PubMed  Google Scholar 

  157. Helmberger T, Ros P, Mergo P, Tomczak R, Reiser M. Pediatric liver neoplasms: a radiologic–pathologic correlation. Eur Radiol. 1999;9(7):1339–47.

    Article  CAS  PubMed  Google Scholar 

  158. Ishak KG, Goodman ZD, Stocker JT. Tumors of the liver and intrahepatic bile ducts. Washington, DC. Armed Forces Institute of Pathology; 2001.

    Google Scholar 

  159. Stocker JT. Hepatic tumors in children. Clin Liver Dis. 2001;​5(1):259–81.

    Article  CAS  PubMed  Google Scholar 

  160. Masand PM. Magnetic resonance imaging features of common focal liver lesions in children. Pediatr Radiol. 2018;48(9):1234–44.

    Google Scholar 

  161. Powers C, Ros PR, Stoupis C, Johnson WK, Segel KH. Primary liver neoplasms: MR imaging with pathologic correlation. Radiographics. 1994;14(3):459–82.

    Article  CAS  PubMed  Google Scholar 

  162. Uchida H, Sakamoto S, Sasaki K, Takeda M, Hirata Y, Fukuda A, et al. Surgical treatment strategy for advanced hepatoblastoma: resection versus transplantation. Pediatr Blood Cancer. 2018;65(12):e27383.

    Article  PubMed  Google Scholar 

  163. Matthew Hawkins C, Towbin AJ, Roebuck DJ, Monroe EJ, Gill AE, Thakor AS, et al. Role of interventional radiology in managing pediatric liver tumors: part 2: percutaneous interventions. Pediatr Radiol. 2018;48(4):565–80.

    Article  CAS  PubMed  Google Scholar 

  164. Lungren MP, Towbin AJ, Roebuck DJ, Monroe EJ, Gill AE, Thakor A, et al. Role of interventional radiology in managing pediatric liver tumors. Pediatr Radiol. 2018;48(4):555–64.

    Article  PubMed  Google Scholar 

  165. Czauderna P. Adult type vs. childhood hepatocellular carcinoma--are they the same or different lesions? Biology, natural history, prognosis, and treatment. Med Pediatr Oncol. 2002;39(5):519–23.

    Article  CAS  PubMed  Google Scholar 

  166. Khanna R, Verma SK. Pediatric hepatocellular carcinoma. World J Gastroenterol. 2018;24(35):3980–99.

    Article  PubMed  PubMed Central  Google Scholar 

  167. Chavhan GB, Siddiqui I, Ingley KM, Gupta AA. Rare malignant liver tumors in children. Pediatr Radiol. 2019;49(11):1404–21.

    Article  PubMed  Google Scholar 

  168. Chavhan GB, Shelmerdine S, Jhaveri K, Babyn PS. Liver MR imaging in children: current concepts and technique. Radiographics. 2016;36(5):1517–32.

    Article  PubMed  Google Scholar 

  169. Angelico R, Grimaldi C, Saffioti MC, Castellano A, Spada M. Hepatocellular carcinoma in children: hepatic resection and liver transplantation. Transl Gastroenterol Hepatol. 2018;3:59.

    Article  PubMed  PubMed Central  Google Scholar 

  170. Mavros MN, Mayo SC, Hyder O, Pawlik TM. A systematic review: treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma. J Am Coll Surg. 2012;215(6):820–30.

    Article  PubMed  Google Scholar 

  171. McLarney JK, Rucker PT, Bender GN, Goodman ZD, Kashitani N, Ros PR. Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 1999;19(2):453–71.

    Article  CAS  PubMed  Google Scholar 

  172. Ganeshan D, Szklaruk J, Kundra V, Kaseb A, Rashid A, Elsayes KM. Imaging features of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 2014;202(3):544–52.

    Article  PubMed  Google Scholar 

  173. Mafeld S, French J, Tiniakos D, Haugk B, Manas D, Littler P. Fibrolamellar hepatocellular carcinoma: treatment with Yttrium-90 and subsequent surgical resection. Cardiovasc Intervent Radiol. 2018;41(5):816–20.

    Article  PubMed  PubMed Central  Google Scholar 

  174. Stocker JT, Ishak KG. Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. Cancer. 1978;42(1):336–48.

    Article  CAS  PubMed  Google Scholar 

  175. Qiu LL, Yu RS, Chen Y, Zhang Q. Sarcomas of abdominal organs: computed tomography and magnetic resonance imaging findings. Semin Ultrasound CT MR. 2011;32(5):405–21.

    Article  PubMed  Google Scholar 

  176. Gabor F, Franchi-Abella S, Merli L, Adamsbaum C, Pariente D. Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. Pediatr Radiol. 2016;46(12):​1694–704.

    Article  PubMed  Google Scholar 

  177. Engel ER, Cournoyer E, Adams DM, Stapleton S. A retrospective review of the use of Sirolimus for pediatric patients with epithelioid hemangioendothelioma (EHE). J Pediatr Hematol Oncol. 2020;42(8):e826–9.

    Google Scholar 

  178. Geramizadeh B, Safari A, Bahador A, Nikeghbalian S, Salahi H, Kazemi K, et al. Hepatic angiosarcoma of childhood: a case report and review of literature. J Pediatr Surg. 2011;46(1):e9–11.

    Google Scholar 

  179. Abdullah A, Patel Y, Lewis TJ, Elsamaloty H, Strobel S. Extrarenal malignant rhabdoid tumors: radiologic findings with histopathologic correlation. Cancer Imaging. 2010;10:97–101.

    Article  PubMed  PubMed Central  Google Scholar 

  180. Garces-Inigo EF, Leung R, Sebire NJ, McHugh K. Extrarenal rhabdoid tumours outside the central nervous system in infancy. Pediatr Radiol. 2009;39(8):817–22.

    Article  PubMed  Google Scholar 

  181. Kapral N, Melmer P, Druzgal CH, Lancaster L. Pediatric hepatic rhabdoid tumor: a rare cause of abdominal mass in children. Radiol Case Rep. 2018;13(3):724–7.

    Article  PubMed  PubMed Central  Google Scholar 

  182. Cornet M, De Lambert G, Pariente D, Planchon JM, Guettier C, Martelli H, et al. Rhabdoid tumor of the liver: report of 6 pediatric cases treated at a single institute. Pediatr Surg. 2018;53(3):567–71.

    Article  Google Scholar 

  183. Danila M, Popescu A, Sirli R, Sporea I, Martie A, Sendroiu M. Contrast enhanced ultrasound (CEUS) in the evaluation of liver metastases. Med Ultrason. 2010;12(3):233–7.

    PubMed  Google Scholar 

  184. Van den Eynden GG, Majeed AW, Illemann M, Vermeulen PB, Bird NC, Hoyer-Hansen G, et al. The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications. Cancer Res. 2013;73(7):2031–43.

    Article  PubMed  Google Scholar 

  185. Fernandez-Pineda I, Sandoval JA, Davidoff AM. Hepatic metastatic disease in pediatric and adolescent solid tumors. World J Hepatol. 2015;7(14):1807–17.

    Article  PubMed  PubMed Central  Google Scholar 

  186. Dong Y, Mao F, Cao J, Fan P, Wang WP. Characterization of focal liver lesions indistinctive on B mode ultrasound: benefits of contrast-enhanced ultrasound. Biomed Res Int. 2017;2017:​8970156.

    Article  PubMed  PubMed Central  Google Scholar 

  187. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29(1):252–60.

    Article  CAS  PubMed  Google Scholar 

  188. Tomasian A, Sandrasegaran K, Elsayes KM, Shanbhogue A, Shaaban A, Menias CO. Hematologic malignancies of the liver: spectrum of disease. Radiographics. 2015;35(1):71–86.

    Article  PubMed  Google Scholar 

  189. Leite NP, Kased N, Hanna RF, Brown MA, Pereira JM, Cunha R, et al. Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics. 2007;27(6):​1613–34.

    Article  PubMed  Google Scholar 

  190. Trenker C, Kunsch S, Michl P, Wissniowski TT, Goerg K, Goerg C. Contrast-enhanced ultrasound (CEUS) in hepatic lymphoma: retrospective evaluation in 38 cases. Ultraschall Med. 2014;35(2):142–8.

    CAS  PubMed  Google Scholar 

  191. Camacho JC, Moreno CC, Harri PA, Aguirre DA, Torres WE, Mittal PK. Posttransplantation lymphoproliferative disease: proposed imaging classification. Radiographics. 2014;34(7):2025–38.

    Article  PubMed  Google Scholar 

  192. Bakker NA, van Imhoff GW, Verschuuren EA, van Son WJ. Presentation and early detection of post-transplant lymphoproliferative disorder after solid organ transplantation. Transpl Int. 2007;20(3):207–18.

    Article  CAS  PubMed  Google Scholar 

  193. Végso G, Hajdu M, Sebestyén A. Lymphoproliferative disorders after solid organ transplantation—classification, incidence, risk factors, early detection and treatment options. Pathol Oncol Res. 2011;17(3):443–54.

    Google Scholar 

  194. Paya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, et al. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic organized international consensus development meeting. Transplantation. 1999;68(10):1517–25.

    Article  CAS  PubMed  Google Scholar 

  195. Jeong HJ, Ahn YH, Park E, Choi Y, Yi NJ, Ko JS, et al. Posttransplantation lymphoproliferative disorder after pediatric solid organ transplantation: experiences of 20 years in a single center. Korean J Pediatr. 2017;60(3):86–93.

    Article  PubMed  PubMed Central  Google Scholar 

  196. Chiou FK, Beath SV, Wilkie GM, Vickers MA, Morland B, Gupte GL. Cytotoxic T-lymphocyte therapy for post-transplant lymphoproliferative disorder after solid organ transplantation in children. Pediatr Transplant. 2018;22(2).

    Google Scholar 

  197. Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ. Clinical presentation of childhood leukaemia: a systematic review and meta-analysis. Arch Dis Child. 2016;101(10):894–901.

    Article  PubMed  Google Scholar 

  198. Sayyed AH, Aleem A, Al-Katari MS, Algahtani F, Aljerian K, Aleem TA, et al. Acute lymphoblastic leukemia presenting with liver infiltration and severe lactic acidosis. Am J Case Rep. 2018;19:​453.

    Article  PubMed  PubMed Central  Google Scholar 

  199. Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer. 1981;48(6):1426–37.

    Article  CAS  PubMed  Google Scholar 

  200. D'Alessandro AM, Knechtle SJ, Chin LT, Fernandez LA, Yagci G, Leverson G, et al. Liver transplantation in pediatric patients: twenty years of experience at the University of Wisconsin. Pediatr Transplant. 2007;11(6):661–70.

    Article  CAS  PubMed  Google Scholar 

  201. Rawal N, Yazigi N. Pediatric liver transplantation. Pediatr Clin North Am. 2017;64(3):677–84.

    Article  PubMed  Google Scholar 

  202. Organ Procurement and Transplantation Network database [Internet]. Available from: https://optn.transplant.hrsa.gov/.

  203. McGuire MT, Phelps A, Paltiel HJ. Pediatric visceral transplantation. Ultrasound Clin. 2013;8(3):375–401.

    Article  Google Scholar 

  204. Fine RN, Webber SA, Harmon WE, Kelly DA, Olthoff KM. Pediatric solid organ transplantation. 2nd ed. Hoboken. Wiley; 2009.

    Google Scholar 

  205. Kamran Hejazi Kenari S, Mirzakhani H, Eslami M, Saidi RF. Current state of the art in management of vascular complications after pediatric liver transplantation. Pediatr Transplant. 2015;19(1):18–26.

    Article  PubMed  Google Scholar 

  206. Ben-Ami TE, Martich V, Yousefzadeh DK, Whitington PF, Emond JC. Anatomic features of reduced-size liver transplant: postsurgical imaging characteristics. Radiology. 1993;187(1):165–70.

    Article  CAS  PubMed  Google Scholar 

  207. Horvat N, Marcelino ASZ, Horvat JV, Yamanari TR, Batista Araújo-Filho JDA, Panizza P, et al. Pediatric liver transplant: techniques and complications. Radiographics. 2017;37(6):1612–31.

    Article  PubMed  Google Scholar 

  208. Dani G, Sun MR, Bennett AE. Imaging of liver transplant and its complications. Semin Ultrasound CT MR. 2013;34(4):365–77.

    Article  PubMed  Google Scholar 

  209. Karakayali F, Kırnap M, Akdur A, Tutar N, Boyvat F, Moray G, et al. Biliary complications after pediatric liver transplantation. Transplant Proc. 2013;45(10):3524–7.

    Google Scholar 

  210. Bonini G, Pezzotta G, Morzenti C, Agazzi R, Nani R. Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound. 2007;10(2):99–106.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  211. Torres A, Koskinen SK, Gjertsen H, Fischler B. Contrast-enhanced ultrasound for identifying circulatory complications after liver transplants in children. Pediatr Transplant. 2019;23(1):e13327.

    PubMed  Google Scholar 

  212. Rennert J, Dornia C, Georgieva M, Roehrl S, Fellner C, Schleder S, et al. Identification of early complications following liver transplantation using contrast enhanced ultrasound (CEUS). First results. J Gastrointestin Liver Dis. 2012;21(4):407–12.

    PubMed  Google Scholar 

  213. Lee DH, Lee JY, Bae JS, Yi NJ, Lee KW, Suh KS, et al. Shear-wave dispersion slope from US shear-wave elastography: detection of allograft damage after liver transplantation. Radiology. 2019;293(2):327–33.

    Article  PubMed  Google Scholar 

  214. Stanescu AL, Hryhorczuk AL, Chang PT, Lee EY, Phillips GS. Pediatric abdominal organ transplantation: current indications, techniques, and imaging findings. Radiol Clin North Am. 2016;54(2):​281–302.

    Article  PubMed  Google Scholar 

  215. Herrmann J, Tozakidou M, Busch J, Herden U, Fischer L, Groth M, et al. Persistence of post-operative color Doppler abnormalities is linked to reduced graft survival in pediatric patients after liver transplantation. Pediatr Transplant. 2019;23(8):e13593.

    Article  PubMed  Google Scholar 

  216. Berrocal T, Parron M, Alvarez-Luque A, Prieto C, Santamaria ML. Pediatric liver transplantation: a pictorial essay of early and late complications. Radiographics. 2006;26(4):1187–209.

    Article  PubMed  Google Scholar 

  217. Unsinn KM, Freund MC, Ellemunter H, Ladurner R, Koenigsrainer A, Gassner I, et al. Spectrum of imaging findings after pediatric liver transplantation: part 2, posttransplantation complications. AJR Am J Roentgenol. 2003;181(4):1139–44.

    Article  PubMed  Google Scholar 

  218. Pascher A, Neuhaus P. Bile duct complications after liver transplantation. Transpl Int. 2005;18(6):627–42.

    Article  PubMed  Google Scholar 

  219. Carmody IC, Romano J, Bohorquez H, et al. Novel biliary reconstruction techniques during liver transplantation. Ochsner J. 2017;17(1):42–5.

    PubMed  PubMed Central  Google Scholar 

  220. Stanescu AL, Kamps SE, Dick AAS, Parisi MT, Phillips GS. Intraoperative Doppler sonogram in pediatric liver transplants: a pictorial review of intraoperative and early postoperative complications. Pediatr Radiol. 2018;48(3):401–10.

    Article  PubMed  Google Scholar 

  221. Crossin JD, Muradali D, Wilson SR. US of liver transplants: normal and abnormal. Radiographics. 2003;23(5):1093–114.

    Article  PubMed  Google Scholar 

  222. Pedersoli F, Isfort P, Keil S, Goerg F, Zimmermann M, Liebl M, et al. Stentgraft implantation for the treatment of postoperative hepatic artery pseudoaneurysm. Cardiovasc Intervent Radiol. 2016;39(4):575–81.

    Google Scholar 

  223. Aydogdu S, Tumgor G, Parildar M, Arikan C, Aydin U, Yuzer Y, et al. Acute hepatic vein thrombosis after liver transplantation in a child with biliary atresia and absent inferior vena cava. Transplant Proc. 2006;38(5):1459–60.

    Google Scholar 

  224. Suzuki L, de Oliveira IR, Widman A, Gibelli NE, Carnevale FC, Maksoud JG, et al. Real-time and Doppler US after pediatric segmental liver transplantation: II. Hepatic vein stenosis. Pediatr Radiol. 2008;38(4):409–14.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeannie K. Kwon .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kwon, J.K. et al. (2021). Liver. In: Paltiel, H.J., Lee, E.Y. (eds) Pediatric Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-030-56802-3_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-56802-3_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56801-6

  • Online ISBN: 978-3-030-56802-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics