Skip to main content
SpringerLink
Log in

Technetium Tc 99m plasmin in the diagnosis of inflammatory disease

  • Published:
European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract

The localization characteristics of technetium Tc 99m plasmin were studied in experimental animals to investigate the use of99mTc-plasmin for imaging inflammatory processes. At various times after abscess induction using turpentine in rats, the in vivo distribution properties of99mTc-plasmin, gallium citrate Ga 67,125I-fibrinogen, and99mTc-human serum albumin (HSA) were studied by gamma-camera imaging. The in vivo binding of each radiopharmaceutical was also tested in rat and human plasma clots. Region-of-interest analyses of gamma-camera images showed relatively poor99mTc-plasmin localization at sites of abscess formation. The ratio of abscess-to-control activity of this radiopharmaceutical did not exceed that of67Ga,125I-fibrinogen, or99mTc-HSA. In vitro assays of each of the radiopharmaceuticals in plasma clots showed99mTc-phasmin and125I-fibrinogen to have the best localization characteristics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Deacon JM, Ell PJ, Anderson P, Khan O (1980) Technetium-99m plasmin: a new test for the detection of deep vein thrombosis. Br J Radiol 53:673–677

    Google Scholar 

  • Persson B, Olsson CG, Darte L, Strand SE, Bergqvist L, Ståhlberg F (1980) Preparation and testing of99mTc-labeled plasmin for thrombus detection. Second Symposium of Radiopharmacology, 6–8 November 1980. Noordwijkerhout, The Netherlands

  • Sakata Y, Aoki N (1980) Cross-linking of alpha-2-plasmin inhibitor to fibrin by fibrin-stabilizing factor. J Clin Invest 65:290–297

    Google Scholar 

  • Sundrehagen E (1982) Is99mTc-plasmin suitable for detection of deep vein thrombosis? Nuclear Medicine and Biology, Proceedings of the Third World Congress of Nuclear Medicine and Biology, C. Raynaud, ed., August 29 to Semptember 2, 1982, Pergamon Press, Paris, vol 1, pp 926–928

    Google Scholar 

Download references

Author information

Author notes

  1. Azu Owunwanne

    Present address: Department of Radiology and Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Kuwait

Authors and Affiliations

  1. Division of Nuclear Medicine, Department of Radiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA

    Azu Owunwanne, David A. Weber, Irving L. Spar, George A. Wilson & Robert E. O'Mara

  2. Department of Radiation Biology and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA

    David A. Weber & Irving L. Spar

Authors
  1. Azu Owunwanne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Irving L. Spar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. George A. Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert E. O'Mara
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Owunwanne, A., Weber, D.A., Spar, I.L. et al. Technetium Tc 99m plasmin in the diagnosis of inflammatory disease. Eur J Nucl Med 12, 496–499 (1987). https://doi.org/10.1007/BF00620473

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00620473

Key words

Search

Navigation