Summary
ZRDCT-An mice are anophthalmic mutants with varying degrees of hypogenesis of the mediobasal hypothalamus and suprachias-matic nuclei. Statistical analysis of the wheelrunning activity patterns of these animals showed that most mice had circadian activity rhythms unentrained to the light-dark cycle. However, four of 22 animals had random or non-circadian activity patterns. Of these four mice, three had fewer than one third the typical number of cells in the suprachiasmatic nuclei. The absence of detectable circadian rhythms in mice with genetically produced hypogenesis of the suprachiasmatic nuclei is reminiscent of the effects of partial electrolytic lesions of the same tissue.
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Abbreviations
- SCN :
-
suprachiasmatic nuclei
- LD :
-
light dark
- DD :
-
dark-dark
References
Balemans MGM, Pèvet P, Legerstee WC, Nevo E (1980) Preliminary investigations on melatonin and 5-methoxy-tryptophol synthesis in the pineal, retina, and Harderian gland of the mole rat and in the pineal of the mouse “eyeless” (sic). J Neural Trans 49:247–255
Brown-Grant K, Raisman G (1977) Abnormalities in reproductive function associated with the destruction of the suprachiasmatic nuclei in female rats. Proc R Soc Lond [Biol] 198:279–296
Sunning E (1973) The physiological clock, 3rd edn. Springer, Berlin Heidelberg New York
Chase HB, Chase ES (1941) Studies on an anophthalmic strain of mice. I. Embryology of the eye region. J Morphol 68:279–301
Faradji H, Cespuglio R, Rondot G, Paut L, Jouvet M (1980) Absence of light-dark entrainment on the sleep-waking cycle in mice with intact visual perception. Brain Res 202:41–49
Faradji H, Cespuglio R, Jouvet M (1981) Phasic events of paradoxical sleep in the anophthalmic ZRDCT/An mice. Physiol Behav 26:961–965
Helwig JT, Council KA (eds) (1979) SAS user's guide. SAS Institute, Gary, North Carolina
Menaker M (1974) Aspects of the physiology of circadian rhythms in the vertebrate central nervous system. In: Schmitt FO, Worden FG (eds) The neurosciences: Third study program. MIT Press, Cambridge
Moore RY (1973) Retinohypothalamic projection in mammals: A comparative study. Brain Res 49:403–409
Moore RY, Lenn NJ (1972) A retinohypothalamic projection in the rat. J Comp Neurol 146:1–14
Pittendrigh CS (1974) Circadian oscillations in cells and the circadian organization of multicellular systems. In: Schmitt FO, Worden FG (eds) The neurosciences: Third study program. MIT Press, Cambridge
Raisman G, Brown-Grant K (1977) The “suprachiasmatic syndrome”: Endocrine and behavioral abnormalities following lesions of the suprachiasmatic nuclei in the female rat. Proc R Soc Lond [Biol] 198:297–314
Richter CP (1971) Inborn nature of the rat's 24-hour clock. J Comp Physiol Psychol 75:1–4
Rusak B (1977a) Involvement of the primary optic tracts in mediation of light effects on hamster circadian rhythms. J Comp Physiol 118:165–172
Rusak B (1977b) The role of the suprachiasmatic nuclei in the generation of circadian rhythms in the golden hamster,Mesocricetus auratus. J Comp Physiol 118:145–164
Silver J (1977a) Abnormal development of the suprachiasmatic nuclei of the hypothalamus in a strain of genetically anophthalmic mice. J Comp Neurol 176:589–606
Silver J (1977b) Abnormal development of the suprachiasmatic nuclei of the hypothalamus in a strain of genetically eyeless mice (ZRDCT-AN). Anat Rec 187:712
Silver J, Brand S (1979) A route for direct retinal input to the preoptic hypothalamus: Dendritic projections into the optic chiasm. Am J Anat 155:391–402
Silver J, Hughes ARW (1974) The relationship between morphogenetic cell death and the development of congenital anophthalmia. J Comp Neurol 157:281–302
Stephan FK, Zucker I (1972a) Rat drinking rhythms: Central visual pathways and endocrine factors mediating responsiveness to environmental illumination. Physiol Behav 8:315–326
Stephan FK, Zucker I (1972b) Circadian rhythms in drinking behavior and locomotor activity in rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci USA 69:1583–1586
Stetson MH, Watson-Whitmyre M (1976) Nucleus suprachiasmaticus: The biological clock in the hamster? Science 191:197–199
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Scheuch, G.C., Johnson, W., Conner, R.L. et al. Investigation of circadian rhythms in a genetically anophthalmic mouse strain: Correlation of activity patterns with suprachiasmatic nuclei hypogenesis. J. Comp. Physiol. 149, 333–338 (1982). https://doi.org/10.1007/BF00619149
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DOI: https://doi.org/10.1007/BF00619149