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Synthesis of antitumoral agents from podophyllotoxin

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Chemistry of Natural Compounds Aims and scope

Abstract

Syntheses based on podophyllotoxin have led to the inclusion among antitumoral agents valuable in practice of the preparations etoposide(I) and teniposide(II). These compounds are, respectively, the 4,6-ethylidene and 4,6-thenylidene derivatives of 4′-dimethylepipodophyllotoxin β-D-glucopyranoside. A review has been made of methods of synthesizing (I) and (II) and for their experimental investigation. Some conclusions are given from the results of clinical trials. Although (I) and (II) have been accepted for practical use, their clinical activity is limited. The principles of the experimental selection of antitumoral agents are considered particularly. Considerations are expressed concerning the possibilities of improving the results of the search for antitumoral agents of plant origin.

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  1. V. V. Kiselev
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All-Union Oncological Scientific Center of the USSR Academy of Medical Sciences, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 638–652, September–October, 1987.

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Kiselev, V.V. Synthesis of antitumoral agents from podophyllotoxin. Chem Nat Compd 23, 529–540 (1987). https://doi.org/10.1007/BF00598666

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