Summary
The histochemical activity pattern of a number of hydroxysteroid dehydrogenases was studied during a provoked hair cycle in the rat skin. The intensity of reaction was high with dehydroepiandrosterone, estradiol, androsterone and pregnenolone, and none with 11-beta-hydroxyprogesterone, testosterone, dihydrotestosterone, 17-alpha-hydroxypregnenolone and 17-alpha-hydroxyprogesterone.
Reactivity also varied with the hair cycle. The reactive sites were the acini of sebaceous glands and the hair sheaths.
Zusammenfassung
Das histochemische Muster einer Reihe von Hydroxysteroid-Dehydrogenasen wurde während des künstlich induzierten Haarcyclus der Ratte untersucht. Ein hoher Reaktionsausfall wurde nach Dehydroepiandrosteron, Oestradiol, Androsteron und Pregnenolon, nicht aber nach 11-Beta-Hydroxyprogesteron, Testosteron, Dihydrotestosteron, 17-Alpha-Hydroxypregnenolon und 17-Alpha-Hydroxyprogesteron beobachtet.
Die Intensität der Reaktion war vom Haarcyclus abhängig. Als reaktive Strukturen erwiesen sich die Talgdrüsenacini und Wurzelscheiden des Haares.
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Franco, C., Rino, B. & Giuseppe, M. Cutaneous hydroxystereoid dehydrogenases and rat-hair-cycle. Arch. Derm. Res. 251, 325–328 (1975). https://doi.org/10.1007/BF00562237
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DOI: https://doi.org/10.1007/BF00562237