Abstract
Several mutations affecting hair growth or quality have been reported in the laboratory mouse (Holland 1988), among them “alopecia” (Dicke 1955), “alopecia periodica” (Tutikawa 1952), “crinkled” (Falconer et al. 1951), “frizzy” (Falconer and Snell 1952), “fuzzy” (Mann 1964), “rhino” (Mann 1971), “naked” (Raphael et al. 1982), “nude” (Flenagen 1966; Buhl et al. 1990; Militzer 2001), “ragged” (Slee 1962), androchronogenetic alopecia (AGA) mouse (Matias et al. 1989), aging C3H/HeJ mice (Sundberg et al. 1994), SPF-ASH mice (Shimada et al. 1994), “nackt” (Benavides et al. 1998), and transgenic mice overexpressing homeobox gene MSX-2 (Jiang et al. 1999). Kligman (1988, 1998) used the Skh-hairless mouse as a model for evaluating promoters of hair growth.
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Benavides F, Giordano M, Fiette L, Brunialti ALB, Palenzuela NM, Vanzulli S, Baldi P, Schmidt R, Pasqualini CD, Guénet JL (1998) Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency. Immunogenetics 49:413–419
Boyera N, Galey I, Bernard BA (1997) Biphasic effects of minoxidil on the proliferation and differentiation of normal human keratinocytes. Skin Pharmacol 10:206–220
Brigham PA, Cappas A, Uno H (1988) The stumptailed macaque as a model for androgenic alopecia: minoxidil analyzed by the use of the folliculogram. Clin Dermatol 6:177–187
Buhl AE, Waldon DJ, Miller BF, Brunden MN (1990) Differences in activity of minoxidil and cyclosporin A on hair growth in nude and normal mice. Comparison of in vivo and in vitro studies. Lab Invest 62:104–107
Cece R, Cazzaniga S, Morelli D, Sfondrini L, Bignotti M, Menard S, Colnaghi MI, Balsari A (1996) Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats. Lab Invest 75:601–609
De Brouwer B, Tételin C, Leroy T, van Bonfils A, Neste D (1997) A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained in testosterone-conditioned nude mice. Br J Dermatol 137:699–702
der Veen V, de Hebeda KM, Bruijn HS, Star WM (1999) Photodynamic effectiveness and vasoconstriction in hairless mouse skin after topical 5-aminolevulinic acid and single- or two-fold illumination. Photochem Photobiol 70:921–929
Diani AR, Shull KL, Brunden MN (1995) The penetration enhancer SEPA augments stimulation of scalp hair by topical minoxidil in the balding stumptail macaque. Skin Pharmacol 8:221–228
Dicke MM (1955) Alopecia, a dominant mutation in the house mouse. J Hered 46:31–34
Falconer DS, Snell GD (1952) Two new hair mutants, rough and frizzy, in the house mouse. J Hered 43:53–57
Falconer DS, Fraser AS, King JWB (1951) The genetics and development of “crinkled”, a new mutant in the house mouse. J Genet 50:324–344
Flenagen SP (1966) Nude, a new hairless gene with pleiotropic effects in the mouse. Genet Res 8:295–309
Herron BJ, Bryda EC, Heverly SA, Collins DN, Flaherty L (1999) Scraggly, a new hair loss mutation on mouse chromosome 19. Mamm Genome 10:864–869
Holland JM (1988) Animal models of alopecia. Clin Dermatol 6:159–162
Jiang T-X, Liu Y-H, Widelitz RB, Kundo RKL, Maxson RE, Chuong CM (1999) Epidermal dysplasia and abnormal hair follicles in transgenic mice overexpressing homeobox gene MSX-2. J Invest Dermatol 113:230–237
Kimura T (1996) Studies on the development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science. Exp Anim 45:1–13
Kligman LH (1988) The hairless mouse as a model for evaluating promoters of hair growth. Clin Dermatol 6:163–168
Kligman LH (1996) The hairless mouse model for photoaging. Clin Dermatol 14:183–195
Kligman AM, Kligman LH (1998) A hairless mouse model for assessing the chronic toxicity of topically applied chemicals. Food Chem Toxicol 36:867–878
Kurata S, Uno H, Allen-Hoffmann BL (1996) Effect of hypertrichotic agents on follicular and nonfollicular cells in vitro. Skin Pharmacol 9:3–8
Lachgar S, Charvéron M, Bouhaddioui N, Neveux Y, Gall Y, Bonafé JL (1996) Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells. Arch Dermatol Res 288:469–473
Mann SJ (1964) The hair of fuzzy mice. J Hered 55:121–123
Mann SJ (1971) Hair loss and cyst formation in hairless and rhino mutant mice. Anat Rec 170:485–500
Matias JR, Malloy V, Orentreich N (1989) Animal models of androgen-dependent disorders of the pilosebaceous apparatus. I. The androchronogenetic alopecia (AGA) mouse as a model for male-pattern baldness. Arch Dermatol Res 281:247–253
McElwee KJ, Rushton DH, Trachy R, Oliver RF (1997) Topical FK506: a potent immunotherapy for alopecia areata? Studies using the Dundee experimental bald rat model. Br J Dermatol 137:491–497
Militzer K (2001) Hair growth pattern in nude mice. Cells Tissues Organs 168:285–294
Oliver RF, Lowe JGB (1995) Oral cyclosporin A restores hair growth in the DEBR rat model for alopecia areata. Clin Exp Dermatol 20:127–131
Pan HJ, Wilding G, Uno H, Inui S, Goldsmith L, Messing E, Chang C (1998) Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stump-tailed macaques. Endocrine 9:39–43
Paus R, Handjiski B, Czarnetzki BM, Eichmüller S (1994a) A murine model for inducing and manipulating hair follicle regression (catagen): effects of dexamethasone and cyclosporin A. J Invest Dermatol 103:143–147
Paus R, Handjiski B, Eichmüller S, Czarnetzki BM (1994b) Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A and modulation by dexamethasone. Am J Pathol 144:719–734
Powis G, Kooistra KL (1987) Doxorubicin-induced hair loss in the Angora rabbit: a study of treatments to protect against hair loss. Cancer Chemother Pharmacol 20:291–296
Raphael KA, Chapman RE, Frith PA (1982) The structure of hair and follicles in mice carrying the naked (N) gene. Genet Res 39:139–148
Sato T, Tadokoro T, Sonada T, Asada Y, Itami S, Takayasu S (1999) Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5a-reductase of cultured human dermal papilla cells from balding scalp. J Dermatol Sci 19:123–125
Shimada T, Tashiro M, Kanzaki T, Noda T, Murakami T, Takiguchi M, Mori M, Yamamura K, Saheki T (1994) Normalization of hair growth in sparse fur-abnormal skin and hair (SPF-ASH) mice by introduction of the rat ornithine transcarbamylase (OTC) gene. J Dermatol Sci 7(Suppl):S27–S32
Shirai A, Ikeda J-I, Kawashima S, Tamaoki T, Kamiya T (2001) KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models. J Dermatol Sci 25:213–218
Slee J (1962) Development morphology of the skin and hair follicles in normal and “ragged” mice. J Embryol Exp Morphol 10:507–529
Sredni B, Xu R-H, Albeck M, Gafter U, Gal R, Shani A, Tichler T, Shapira J, Bruiderman I, Catane R, Kaufman B, Whisnant JK, Mettinger KL, Kalechman Y (1996) The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia. Studies in human and animal models. Int J Cancer 65:97–103
Sundberg JP, Cordy WR, King LE Jr (1994) Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 102:847–856
Tutikawa K (1952) Studies on an apparently new mutant, “alopecia periodica” found in the mouse. Annu Rep Natl Inst Genet Jpn 3:9–10
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Maibach, H. (2016). Influence on Hair Growth. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_110
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DOI: https://doi.org/10.1007/978-3-319-05392-9_110
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