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Norfenefrine: Haemodynamic effects in healthy volunteers at rest and during orthostasis

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Summary

The haemodynamic effects of the alphamimetic norfenfrine 1 · 5–4 · 5 µg/kg/min i.v. were studied by invasive methods in six healthy male volunteers at rest and during orthostasis (90° on tilt table). Norfenefrine was more effective at rest and during exercise in raising blood pressure in the pulmonary than in the systemic arterial system. It was concluded that norfenefrine should be effective in the treatment of patients with orthostatic dysregulation due to reduced venous tone.

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Authors and Affiliations

  1. Abteilung Klinische Pharmakologie der I. Medizinischen Universitäts-Klinik, Wien, Austria

    D. Magometschnigg

  2. Klinische Forschung und Entwicklung der Gödecke AG Freiburg i. Breisgau, Germany

    E. Stengele

Authors
  1. D. Magometschnigg
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  2. E. Stengele
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Magometschnigg, D., Stengele, E. Norfenefrine: Haemodynamic effects in healthy volunteers at rest and during orthostasis. Eur J Clin Pharmacol 25, 167–171 (1983). https://doi.org/10.1007/BF00543786

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  • DOI: https://doi.org/10.1007/BF00543786

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