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Effect of Antiorthostatic Hypokinesia on the Pharmacokinetics and Bioavailability of Propranolol

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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The pharmacokinetics of propranolol were studied in healthy volunteers after a single peroral administration at a dose of 80 mg under normal conditions, on the second day of antiorthostatic hypokinesia, and on the first day after termination of the hypokinesia. The maximum propranolol concentration (–6 ∆%), area under the pharmacokinetic curve (–13 ∆%), elimination half-life (–15 ∆%), mean residence time in the body (–17 ∆%), and distribution volume (–8 ∆%) tended to decrease with antiorthostatic hypokinesia whereas the total clearance (+13 ∆%), ratio of maximum concentrations (125 ± 23%), and relative absorption rate of the drug (158 ± 48%) increased.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8/2 Trubetskaya St., Moscow, 119991, Russia

    S. N. Kondratenko

  2. Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences, 76A Khoroshevskoe Shosse, Moscow, 123007, Russia

    I. V. Kovachevich & L. G. Repenkova

Authors
  1. S. N. Kondratenko
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  2. I. V. Kovachevich
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  3. L. G. Repenkova
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Correspondence to S. N. Kondratenko.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 6, pp. 3 – 6, June, 2018.

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Kondratenko, S.N., Kovachevich, I.V. & Repenkova, L.G. Effect of Antiorthostatic Hypokinesia on the Pharmacokinetics and Bioavailability of Propranolol. Pharm Chem J 52, 491–494 (2018). https://doi.org/10.1007/s11094-018-1845-y

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  • DOI: https://doi.org/10.1007/s11094-018-1845-y

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