Über die Wirkung einiger herzwirksamer Bisguanylhydrazone auf den Veratrineffekt am Frosch-Sartoriusmuskel

Summary

A series of guanylhydrazones was synthesized, some of the substances had a cardiac glycoside-like activity on the mammalian heart whereas other ones acted tyramine-like. The effect of some guanylhydrazones of each kind of action on the “veratrine response” (VR) of the frog's sartorius muscle should be investigated. Following substances were synthesized: 1. with cardiac glycoside-like activity 3,3′-dimethyl-4,4′-diacetyldiphenylbisguanylhydrazone (BG 60), progesteronebisguanylhydrazone (BG 31), p-aceto-m-methyl-phenyl-acetonyl-ether-bisguanylhydrazone (BG 85) 2. with sympathomimetic activity: p-aceto-phenyl-acetonyl-ether-bisguanylhydrazone (BG 81) and p-hydroxybenzaldehyd-monoguanylhydrazone (MG 41). The characteristic influence of the cardiac glycosides on the VR was only to be seen with BG 85 and BG 81. BG 60, BG 31 and BG 41 showed a quinidine-like effect on the VR. That means that from 3 guanylhydrazones with cardiac glycoside-like activity on the mammalian heart two of them had a quinidine-like effect on the VR and only one of them showed the typical cardiac glycoside-like effect on the VR. On the other hand among the guanylhydrazones with tyramine-like activity on the mammalian heart there is one, BG 81, which influenced the VR like a cardiac glycoside.

Zusammenfassung

Die Wirkung einiger Guanylhydrazone sowie von Tyramin auf die „Veratrine-Response“ des Froschsartoriusmuskels wurden untersucht. Von den drei „herzglykosidartigen“ Bisguanylhydrazonen zeigten BG 60 und BG 31 den unspezifischen Veratrinantagonismus des Chinidins. BG 85 hingegen beeinflußte die VR „herzglykosidartig“. Von den drei „tyraminartigen“ Substanzen BG 81, MG 41 und Tyramin wirkten die letzten zwei „chinidinartig“, während BG 81 trotz seiner „tyraminartigen“ Wirkung die VR „herzglykosidartig“ beeinflußte.