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Some transformations of pyrimidine N,N′-dioxides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

(5-Acetoxy-4-phenyl-6-pyrimidinylidene)cyanoacetic ester is formed in the reaction of 4-phenylpyrimidine N,N′-dioxide with cyanoacetic ester in acetic anhydride, whereas 5-hydroxy-6-phenylpyrimidine 1-oxide is formed in chloroform solution in the presence of acetic anhydride. The first compound is converted to a furo[3,2-d] pyrimidine derivative by treatment with alkali, while the second compound is methylated by diazomethane to give the 5-methoxy derivative.

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Authors and Affiliations

  1. Siberian Branch of the Academy of Sciences of the USSR, Novosibirsk Institute of Organic Chemistry, 630090, Novosibirsk

    V. F. Sedova & V. P. Mamaev

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  1. V. F. Sedova
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  2. V. P. Mamaev
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 827–831, June, 1979.

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Sedova, V.F., Mamaev, V.P. Some transformations of pyrimidine N,N′-dioxides. Chem Heterocycl Compd 15, 677–681 (1979). https://doi.org/10.1007/BF00539507

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  • DOI: https://doi.org/10.1007/BF00539507

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