Summary
From biometrical and histological investigations on mice of the C+strain with spontaneous mammary carcinoma a scheme is devised to illustrate the life history of the cancer in which four successive stages are differentiated:
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a)
the biological precancerous phase; this starts with the initial contact of the cancerous agent on the animal and continues until the first appearance of morphologically perceptible changes in the breast glands. (Average duration 2–3 months).
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b)
the morphological precancerous phase follows in successive fashion and shows morphological changes of increasing severity until the appearance of cancer. (Average duration 110.33 days).
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c)
the preclinical phase of the cancer progresses from the time of the first unequivocal development of a tumor and continues until the clinical appearance of a mass. (Average duration 19.29 days.)
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d)
the clinical phase of the cancer lasts from the appearance of the tumor mass until the death of the animal. (Average duration 28.69 days.)
The essential biological and morphological aspects of the different phases are discussed.
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Severi, L., Squartini, F. Die biometrischen Probleme des Krebses. Z Krebs-forsch 61, 180–194 (1956). https://doi.org/10.1007/BF00524334
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DOI: https://doi.org/10.1007/BF00524334