Summary
The effects of indomethacin on changes in renal blood flow induced by adenosine, NECA (adenosine-5′-N-ethyl-carboxamide) and 2′,3′-dinitro-NECA were investigated in 6 chronically instrumented conscious dogs. Adenosine (187.5, 375 and 750 nmol/kg, i.v.) induced a dose-dependent initial decrease, followed by a reactive increase in renal blood flow. NECA (1.5 nmol/kg, i.v.) also induced an initial decrease, which was, however, followed by a prolonged reactive increase in renal blood fow. 2′,3′-dinitro-NECA (50 nmol/kg, orally) induced only an increase in renal blood flow. Indomethacin (27.9 μmol/kg, i.v.) caused no relevant change of the initial decrease and a significant attenuation of the reactive increase in renal blood flow induced by adenosine. NECA-induced changes in blood flow were affected by indomethacin in the same direction but to a greater extent than were adenosine-induced changes in blood flow. Indomethacin reversed the increase to a decrease in renal blood flow induced by 2′,3′-dinitro-NECA. Thus, prostaglandins seem to be involved in mediating the response of renal blood flow to adenosine, NECA and 2′,3′-dinitro-NECA.
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Beck, A., Seitelberger, R. & Raberger, G. Effects of indomethacin on changes in renal blood flow induced by adenosine and its analogues in conscious dogs. Naunyn-Schmiedeberg's Arch. Pharmacol. 326, 75–79 (1984). https://doi.org/10.1007/BF00518782
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DOI: https://doi.org/10.1007/BF00518782