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Synthesis of N-substituted 2-benzoxalones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

3-Acetylaminomethyl-2-benzoxazolones are obtained by Beckmann rearrangement of the anti-oximes of 3-acetonyl-2-benzoxazolones. The isomeric 3-(N-methylcarbamoylmethyl)-2-benzoxazolones are synthesized by alkylation of 2-benzoxazolone with chloroacetic acid, followed by reaction of the 3-carboxymethyl-2-benzoxazolones obtained with thionyl chloride and methylamine.

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Authors and Affiliations

  1. Kl. Okhridskii Sofia University, 1126, Sofia, Bulgaria

    V. Kalcheva, Kh. Lozanova, D. Simov & P. B. Terent'ev

  2. M. V. Lomonosov Moscow State University, 117234, Moscow

    V. Kalcheva, Kh. Lozanova, D. Simov & P. B. Terent'ev

Authors
  1. V. Kalcheva
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  2. Kh. Lozanova
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  3. D. Simov
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  4. P. B. Terent'ev
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1185–1188, September, 1985.

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Kalcheva, V., Lozanova, K., Simov, D. et al. Synthesis of N-substituted 2-benzoxalones. Chem Heterocycl Compd 21, 985–987 (1985). https://doi.org/10.1007/BF00515019

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  • DOI: https://doi.org/10.1007/BF00515019

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