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Distribution of NT-IR perikarya in the brain of the guinea pig with special reference to cardiovascular centers in the medulla oblongata

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Summary

The occurrence and distribution of neurotensin-immunoreactive (NT-IR) perikarya was studied in the central nervous system of the guinea pig using a newly raised antibody (KN 1). Numerous NT-IR perikarya were found in the nuclei amygdaloidei, nuclei septi interventriculare, hypothalamus, nucleus parafascicularis thalami, substantia grisea centralis mesencephali, ventral medulla oblongata, nucleus solitarius and spinal cord. The distribution of NT-IR perikarya was similar to that previously described in the rat and monkey. In the gyrus cinguli, hippocampus and nucleus olfactorius, though, no NT-IR neurons were detected in this investigation. Additional immunoreactive perikarya, however, were observed in areas of the ventral medulla oblongata, namely in the nucleus paragigantocellularis, nucleus retrofacialis and nucleus raphe obscurus.

The relevance of the NT-IR perikarya within the ventral medulla oblongata is discussed with respect to other neuropeptides, which are found in this area, and to cardiovascular regulation.

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Abbreviations

abl:

nucleus amygdaloideus basalis lateralis

abm:

nucleus amygdaloideus basalis medialis

acc:

nucleus amygdaloideus centralis

aco:

nucleus amygdaloideus corticalis

ahp:

area posterior hypothalami

ala:

nucleus amygdaloideus lateralis anterior

alp:

nucleus amygdaloideus lateralis posterior

ame:

nucleus amygdaloideus medialis

atv:

area tegmentalis ventralis

bst:

nucleus proprius striae terminalis

CA:

commissura anterior

CC:

corpus callosum

cgld:

corpus geniculatum laterale dorsale

cglv:

corpus geniculatum laterale ventrale

cgm:

corpus geniculatum mediale

CHO:

chiasma opticum

CI:

capsula interna

co:

nucleus commissuralis

cod:

nucleus cochlearis dorsalis

cp:

nucleus caudatus/Putamen

cs:

colliculus superior

cu:

nucleus cuneatus

dmh:

nucleus dorsomedialis hypothalami

DP:

decussatio pyramidum

em:

eminentia mediana

ent:

cortex entorhinalis

epi:

epiphysis

FLM:

fasciculus longitudinalis medialis

fm:

nucleus paraventricularis hypothalami pars filiformis

FX:

fornix

gd:

gyrus dentatus

gp:

globus pallidus

gr:

nucleus gracilis

hl:

nucleus habenulae lateralis

hm:

nucleus habenulae medialis

hpe:

hippocampus

ift:

nucleus infratrigeminalis

io:

oliva inferior

ip:

nucleus interpeduncularis

LM:

lemniscus medialis

MT:

tractus mamillo-thalamicus

na:

nucleus arcuatus

nls:

nucleus lateralis septi

nms:

nucleus medialis septi

npca:

nucleus proprius commissurae anterioris

ns:

nucleus solitarius

n III:

nucleus nervi oculomotorii

nt V:

nucleus tractus spinalis nervi trigemini

ntm:

nucleus mesencephalicus nervi trigemini

osc:

organum subcommissurale

P:

tractus cortico-spinalis

PC:

pedunculus cerebri

PCI:

pedunculus cerebellaris inferior

pir:

cortex piriformis

pol:

area praeoptica lateralis

pom:

area praeoptica medialis

prt:

area praetectalis

pt:

nucleus parataenialis

pvh:

nucleus paraventricularis hypothalami

pvt:

nucleus paraventricularis thalami

r:

nucleus ruber

re:

nucleus reuniens

rgi:

nucleus reticularis gigantocellularis

rl:

nucleus reticularis lateralis

rm:

nucleus raphe magnus

ro:

nucleus raphe obscurus

rp:

nucleus raphe pallidus

rpc:

nucleus reticularis parvocellularis

rpgc:

nucleus reticularis paragigantocellularis

sch:

nucleus suprachiasmaticus

SM:

stria medullaris thalami

snc:

substantia nigra compacta

snl:

substantia nigra lateralis

snr:

substantia nigra reticularis

ST:

stria terminalis

tad:

nucleus anterior dorsalis thalami

tam:

nucleus anterior medialis thalami

tav:

nucleus anterior ventralis thalami

tbl:

nucleus tuberolateralis

tc:

nucleus centralis thalami

tl:

nucleus lateralis thalami

tmd:

nucleus medialis dorsalis thalami

TO:

tractus opticus

TOL:

tractus olfactorium lateralis

tpo:

nucleus posterior thalami

tr:

nucleus reticularis thalami

trs:

nucleus triangularis septi

TS:

tractus solitarius

TS V:

tractus spinalis nervi trigemini

tvl:

nucleus ventrolateralis thalami

vmh:

nucleus ventromedialis hypothalami

vh:

ventral horn, Columna anterior

zi:

zona incerta

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Authors and Affiliations

  1. Department of Anatomy, University of Heidelberg, Im Neuenheimer Feld 307, D-6900, Heidelberg, Federal Republic of Germany

    J. Triepel, J. Mader, A. Weindl, D. Heinrich, W. G. Forssmann & J. Metz

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  1. J. Triepel
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  2. J. Mader
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  3. A. Weindl
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  4. D. Heinrich
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  5. W. G. Forssmann
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  6. J. Metz
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Supported by the Deutsche Forschungsgesellschaft (DFG) SFB 90, Carvas

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Triepel, J., Mader, J., Weindl, A. et al. Distribution of NT-IR perikarya in the brain of the guinea pig with special reference to cardiovascular centers in the medulla oblongata. Histochemistry 81, 509–516 (1984). https://doi.org/10.1007/BF00489528

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