Abstract
Analysis by starch gel electrophoresis of erythrocyte hemolysates and brain extracts indicated that an electrophoretic variant of lactic dehydrogenase discovered in Peromyscus involves the A subunit. The tetramers containing the variant molecules migrate more rapidly than the normal ones, and the staining reactions suggested a reduced enzymatic activity. Comparisons of the erythrocyte LDH activity of normal and homozygous variant animals indicated that the variant enzyme is intrinsically less active than the normal. The variant is inherited as an autosomal codominant and appears to confer no selective disadvantage.
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This work was supported in part by a grant GM-15885 from the National Institutes of Health, U.S. Public Health Service, and in part by a supporting fund established in the name of Zachary Pitts Research Fellowship.
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Cattanach, B.M., Perez, J.N. A genetically determined variant of the a-subunit of lactic dehydrogenase in the deer mouse. Biochem Genet 3, 499–506 (1969). https://doi.org/10.1007/BF00485610
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DOI: https://doi.org/10.1007/BF00485610