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Indole derivatives

XXIV. Synthesis of some 1, 2, 3, 4, 5, 6-hexahydroazepino[4, 5-b]indoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

By expanding the ring of 1-methyl-4-piperidone with diazomethane we have obtained 1-methyl-1-azacyclopentan-4-one. The Fischer cyclization of arylhydrazones of 1-methyl-1-azacyclopentan-4-one has given 3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole and a number of its derivatives for the first time. The structure of the compounds obtained was shown by a study of their PMR spectra and also by a number of chemical reactions.

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References

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Authors and Affiliations

  1. Institute of Pharmacology and Chemotherapy, Academy of Medical Sciences, Moscow, USSR

    N. M. Sharkova, N. F. Kucherova, S. L. Portnova & V. A. Zagorevskii

Authors
  1. N. M. Sharkova
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  2. N. F. Kucherova
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  3. S. L. Portnova
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  4. V. A. Zagorevskii
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Sharkova, N.M., Kucherova, N.F., Portnova, S.L. et al. Indole derivatives. Chem Heterocycl Compd 4, 101–105 (1970). https://doi.org/10.1007/BF00478095

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  • DOI: https://doi.org/10.1007/BF00478095

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