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5-Amino-pyrazoles: potent reagents in organic and medicinal synthesis

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Abstract

5-Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents comprehensively the applications of 5-amino-pyrazoles as versatile synthetic building blocks in the synthesis of remarkable organic molecules with an emphasis on versatile functionalities. Following a brief introduction of synthesis methods, planning strategies to construct organic compounds, particularly diverse heterocyclic scaffolds, such as poly-substituted heterocyclic compounds and fused heterocyclic compounds via 5-amino-pyrazoles, have been summarized. Fused heterocycles are classified as bicyclic, tricyclic, tetracyclic, and spiro-fused pyrazole derivatives. These outstanding compounds synthesized via wide variety of approaches include conventional reactions, one-pot multi-component reactions, cyclocondensation, cascade/tandem protocols, and coupling reactions. 5-Amino-pyrazoles represent a class of promising functional reagents, similar to the biologically active compounds, highlighted with diverse applications especially in the field of pharmaceutics and medicinal chemistry. Notably, this critical review covers the articles published from 1981 to 2018.

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Acknowledgements

We gratefully acknowledge financial support from the Iran National Science Foundation (INSF) and the Research Council of Shahid Beheshti University.

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  1. Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran

    Ahmad Shaabani, Mohammad Taghi Nazeri & Ronak Afshari

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  1. Ahmad Shaabani
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  2. Mohammad Taghi Nazeri
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  3. Ronak Afshari
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Correspondence to Ahmad Shaabani.

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Shaabani, A., Nazeri, M.T. & Afshari, R. 5-Amino-pyrazoles: potent reagents in organic and medicinal synthesis. Mol Divers 23, 751–807 (2019). https://doi.org/10.1007/s11030-018-9902-8

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