Abstract
A method was developed for the synthesis of the first representative of the previously unreported quinuclidine derivatives with four geminal substituents in the α-positions with respect to nitrogen, viz., 2,2,6,6-tetramethylquinuclidine, from triacetonamine. Two variants were studied for building up the chain from two CH2 links in the γ-position of triacetonamine using the Reformatskii and Knoevenagel reactions.
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Deceased.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 230–234, February, 1971.
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Nikit-skaya, E.S., Levkoeva, E.I., Usovskaya, V.S. et al. Synthesis of 2,2,6,6-tetramethylquinuclidine. Chem Heterocycl Compd 7, 212–216 (1971). https://doi.org/10.1007/BF00473091
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DOI: https://doi.org/10.1007/BF00473091