Abstract
Conditions have been found for the mercuration of alkyl- and aryl- thiazoles. Mercuration takes place in position 5 of the ring, if it is free, and does not depend on the nature of the substituent in position 2. The possibility of the mercuration of a trisubstituted thiazole has been shown for the first time. When a phenyl radical is present in position 2, the mercury ion enters the para position of the phenyl nucleus.
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References
K. Ganapathi and K. Kulbarni, Proc. Indian. Acad. Sci., 38, 45, 1953; 37, 758, RZhKh, 46327-28, 1954.
B. S. Friedman and M. Sparks, J. Am. Chem. Soc., 59, 2262, 1937.
H. Erlenmeyer and C. Becker, Helv. Chim. Acta, 30, 2058, 1947.
O. P. Shvaika and G. P. Klimisha, KhGS [Chemistry of Heterocyclic Compounds], 2, 19, 1966.
Yu. K. Yur'ev and I. G. Zhukova, ZhOKh, 28, 7, 1958.
R. Adams, Organic Synthesis, Vol. 3, [Russian translation], IL, Moscow, 197, 1952.
K. Hubacher, Ann., 259, 236, 1890.
R. Adams, Organic Synthesis, Vol. 6 [Russian translation], IL, Moscow, 311, 1953.
B. I. Mikhailov and B. P. Bronovitskaya, ZhOKh, 27, 730, 1957.
K. Gompper and H. Ruhle, Ann., 626, 91, 1959.
F. Saulmann, Ber., 33, 2636, 1900.
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Gusinskaya, S.L., Telly, V.Y. & Makagonova, T.P. Mercuration of thiazole derivatives. Chem Heterocycl Compd 6, 322–323 (1970). https://doi.org/10.1007/BF00471232
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DOI: https://doi.org/10.1007/BF00471232