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Differentiation of Burkitt Lymphoma cells by Hexamethylenbisacetamide

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Abstract

Hexamethylenbisacetamide (HMBA) can induce the Burkitt lymphoma Raji cells to enter the differentiation process as evidenced by the decrease of HLA-DR antigens. This event is preceded by a decrease of c-myc expression and of the phosphorylation of cellular proteins, due toeither a decrease of tyrosine protein kinase activity or an increase of tyrosine phosphatase activity. These three events form a sequence and are part of the genetic program for differentiation and growth though they may not be causally related.

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Authors and Affiliations

  1. U.A. 1158 C.N.R.S., France

    M. Semmel, N. Hanania, N. Pavloff & F. Gay

  2. Laboratoire d'Immunologie des Tumeurs des Enfants, France

    S. Huet

  3. U.66, INSERM Institut Gustave Roussy Villejuif, 94800, France

    J. M. Biquard

Authors
  1. M. Semmel
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  2. N. Hanania
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  3. S. Huet
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  4. N. Pavloff
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  5. F. Gay
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  6. J. M. Biquard
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Semmel, M., Hanania, N., Huet, S. et al. Differentiation of Burkitt Lymphoma cells by Hexamethylenbisacetamide. Molecular Biology Reports 13, 151–157 (1988). https://doi.org/10.1007/BF00444311

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  • DOI: https://doi.org/10.1007/BF00444311

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