Skip to main content
Log in

Facilitating effects of chlordiazepoxide on locomotor activity and avoidance behaviour of reserpinized mice

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Chlordiazepoxide increased the spontaneous locomotor activity of both normal and reserpinized mice and facilitated the avoidance behaviour of mice pretreated with reserpine. These effects of chlorodiazepoxide on reserpinized animals were unexpected, since they are usually considered characteristic of antidepressant drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Ahtee, L., Shillito, E.: The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice. Br. J. Pharmacol. 40, 361–371 (1970)

    Google Scholar 

  • Babbini, M., Montanaro, N., Strocchi, P., Gaiardi, M.: Enhancement of amphetamine-induced stereotyped behavior by benzodiazepines. Eur. J. Pharmacol. 13, 330–340 (1971)

    Google Scholar 

  • Boissier, J. R., Simon, P., Lwoff, J. M.: Sur une action paradoxale du chlordiazepoxide. Thérapie 18, 1247–1256 (1963)

    Google Scholar 

  • Carlsson, A., Engel, J., Svensson, T. H.: Inhibition of ethanol-induced excitation in mice and rats by α-methyl-p-tyrosine. Psychopharmacologia (Berl.) 26, 307–312 (1972)

    Google Scholar 

  • Chester, G. B.: Facilitation of avoidance acquisition in the rat by ethanol and its abolition by α-methyl-p-tyrosine. Psychopharmacologia (Berl.) 39, 87–95 (1974)

    Google Scholar 

  • Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970)

    Google Scholar 

  • Di Mascio, A.: The effects of benzodiazepines on aggression:reduced or increased? In: The benzodiazepines, S. Garattin, E. Mussini, and L. O. Randall, eds., pp. 433–440. New York: Raven 1973

    Google Scholar 

  • Dorr, M., Steinberg, H., Tomkiewicz, M., Joyce, D., Porsolt, R. D., Summerfield, A.: Persistence of dose related behaviour in mice. Nature (Lond.) 231, 121–123 (1971)

    Google Scholar 

  • Hughes, R. N.: Chlordiazepoxide modified exploration in rats. Psychopharmacologia (Berl.) 24, 462–469 (1972)

    Google Scholar 

  • Iwahara, S., Sakama, E.: Effects of chlordiazepoxide upon habituation of open-field behavior in white rats. Psychopharmacologia (Berl.) 27, 285–292 (1972)

    Google Scholar 

  • Kumar, R.: Extinction of fear. II. Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats. Psychopharmacologia (Berl.) 19, 297–312 (1971)

    Google Scholar 

  • Kumar, R., Stolerman, I. P., Steinberg, H.: Psychopharmacology. Annu. Rev. Psychol. 21, 595–628 (1970)

    Google Scholar 

  • Marriott, A. S., Smith, E. F.: An analysis of drug effects in mice exposed to a simple novel environment. Psychopharmacologia (Berl.) 24, 397–406 (1972)

    Google Scholar 

  • Marriott, A. S., Spencer, P. S. J.: Effects of centrally acting drugs on exploratory behaviour in rats. Br. J. Pharmacol. 25, 432–441 (1965)

    Google Scholar 

  • Miczek, K. A.: Intraspecies aggression in rats: effects of d-amphetamine and chlordiazepoxide. Psychopharmacologia (Berl.) 39, 275–301 (1974)

    Google Scholar 

  • Montuori, E., Gonzàlez, H. A., Ceñal, E. E.: Estudio farmacologico de una mezela de clorometilfenil-benzodiazepinona y clorhidrato de clorometaminodiazepòxido. Revta. Soc. Argent. Biol. 45, 88–98 (1969)

    Google Scholar 

  • Nolan, N. A., Parkes, M. W.: The effects of benzodiazepines on the behaviour of mice on a hole-board. Psychopharmacologia (Berl.) 29, 277–288 (1973)

    Google Scholar 

  • Oliverio, A., Castellano, C.: Genotype-dependent sensitivity and tolerance to morphine and heroin: dissociation between opiate-induced running and analgesia in the mouse. Psychopharmacologia (Berl.) 39, 13–22 (1974)

    Google Scholar 

  • Rushton, R., Steinberg, H.: Combined effects of chlordiazepoxide and dexamphetamine on activity of rats in an unfamiliar environment. Nature (Lond.) 211, 1312–1313 (1966)

    Google Scholar 

  • Rushton, R., Steinberg, H.: Drug combinations and their analysis by means of exploratory activity in rats. In: Neuropsychopharmacology, H. Brill, J. O. Cole, P. Deniker, H. Hippius, and P. B. Bradley, eds., pp. 464–470. Amsterdam: Excerpta Medica 1967

    Google Scholar 

  • Rushton, R., Steinberg, H., Tomkiewicz, M.: Effects of chlordiazepoxide alone and in combination with amphetamine on animal and human behavior. In: The benzodiazepines, S. Garattini, E. Mussini, and L. O. Randall, eds., pp. 355–366. New York: Raven 1973

    Google Scholar 

  • Sansone, M.: Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice. Psychopharmacologia (Berl.) 41, 117–121 (1975a)

    Google Scholar 

  • Sansone, M.: Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice. Arch. Int. Pharmacodyn. 215, 190–196 (1975b)

    Google Scholar 

  • Sansone, M.: Benzodiazepines and amphetamine on avoidance behaviour in mice. Arch. Int. Pharmacodyn. 218, 125–132 (1975c)

    Google Scholar 

  • Sethy, V. H., Naik, P. Y., Sheth, U. H.: Effect of d-amphetamine sulphate in combination with CNS depressants on spontaneous motor activity of mice. Psychopharmacologia (Berl.) 18, 19–25 (1970)

    Google Scholar 

  • Sulser, F., Bass, A. D.: Pharmacodynamic and biochemical considerations on the mode of action of reserpine-like drugs. In: Psychopharmacology. A review of progress 1957–1967, D. H. Efron, ed., Public Health Service Publication No. 1836, pp. 1065–1075. Washington, D.C.: Public Health Service 1968

    Google Scholar 

  • Valzelli, L.: Activity of benzodiazepines on aggressive behavior in rats and mice. In: The benzodiazepines. S. Garattini, E. Mussini, and L. O. Randall, eds., pp. 405–417. New York: Raven 1973

    Google Scholar 

  • van Rossum, J. M.: Mode of action of psychomotor stimulant drugs. Int. Rev. Neurobiol. 12, 307–383 (1970)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sansone, M. Facilitating effects of chlordiazepoxide on locomotor activity and avoidance behaviour of reserpinized mice. Psychopharmacology 59, 157–160 (1978). https://doi.org/10.1007/BF00427750

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00427750

Key words

Navigation