Advertisement

Psychopharmacology

, Volume 59, Issue 2, pp 157–160 | Cite as

Facilitating effects of chlordiazepoxide on locomotor activity and avoidance behaviour of reserpinized mice

  • Mario Sansone
Original Investigations

Abstract

Chlordiazepoxide increased the spontaneous locomotor activity of both normal and reserpinized mice and facilitated the avoidance behaviour of mice pretreated with reserpine. These effects of chlorodiazepoxide on reserpinized animals were unexpected, since they are usually considered characteristic of antidepressant drugs.

Key words

Chlordiazepoxide Reserpine Locomotor activity Avoidance behaviour Mice 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahtee, L., Shillito, E.: The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice. Br. J. Pharmacol. 40, 361–371 (1970)Google Scholar
  2. Babbini, M., Montanaro, N., Strocchi, P., Gaiardi, M.: Enhancement of amphetamine-induced stereotyped behavior by benzodiazepines. Eur. J. Pharmacol. 13, 330–340 (1971)Google Scholar
  3. Boissier, J. R., Simon, P., Lwoff, J. M.: Sur une action paradoxale du chlordiazepoxide. Thérapie 18, 1247–1256 (1963)Google Scholar
  4. Carlsson, A., Engel, J., Svensson, T. H.: Inhibition of ethanol-induced excitation in mice and rats by α-methyl-p-tyrosine. Psychopharmacologia (Berl.) 26, 307–312 (1972)Google Scholar
  5. Chester, G. B.: Facilitation of avoidance acquisition in the rat by ethanol and its abolition by α-methyl-p-tyrosine. Psychopharmacologia (Berl.) 39, 87–95 (1974)Google Scholar
  6. Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970)Google Scholar
  7. Di Mascio, A.: The effects of benzodiazepines on aggression:reduced or increased? In: The benzodiazepines, S. Garattin, E. Mussini, and L. O. Randall, eds., pp. 433–440. New York: Raven 1973Google Scholar
  8. Dorr, M., Steinberg, H., Tomkiewicz, M., Joyce, D., Porsolt, R. D., Summerfield, A.: Persistence of dose related behaviour in mice. Nature (Lond.) 231, 121–123 (1971)Google Scholar
  9. Hughes, R. N.: Chlordiazepoxide modified exploration in rats. Psychopharmacologia (Berl.) 24, 462–469 (1972)Google Scholar
  10. Iwahara, S., Sakama, E.: Effects of chlordiazepoxide upon habituation of open-field behavior in white rats. Psychopharmacologia (Berl.) 27, 285–292 (1972)Google Scholar
  11. Kumar, R.: Extinction of fear. II. Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats. Psychopharmacologia (Berl.) 19, 297–312 (1971)Google Scholar
  12. Kumar, R., Stolerman, I. P., Steinberg, H.: Psychopharmacology. Annu. Rev. Psychol. 21, 595–628 (1970)Google Scholar
  13. Marriott, A. S., Smith, E. F.: An analysis of drug effects in mice exposed to a simple novel environment. Psychopharmacologia (Berl.) 24, 397–406 (1972)Google Scholar
  14. Marriott, A. S., Spencer, P. S. J.: Effects of centrally acting drugs on exploratory behaviour in rats. Br. J. Pharmacol. 25, 432–441 (1965)Google Scholar
  15. Miczek, K. A.: Intraspecies aggression in rats: effects of d-amphetamine and chlordiazepoxide. Psychopharmacologia (Berl.) 39, 275–301 (1974)Google Scholar
  16. Montuori, E., Gonzàlez, H. A., Ceñal, E. E.: Estudio farmacologico de una mezela de clorometilfenil-benzodiazepinona y clorhidrato de clorometaminodiazepòxido. Revta. Soc. Argent. Biol. 45, 88–98 (1969)Google Scholar
  17. Nolan, N. A., Parkes, M. W.: The effects of benzodiazepines on the behaviour of mice on a hole-board. Psychopharmacologia (Berl.) 29, 277–288 (1973)Google Scholar
  18. Oliverio, A., Castellano, C.: Genotype-dependent sensitivity and tolerance to morphine and heroin: dissociation between opiate-induced running and analgesia in the mouse. Psychopharmacologia (Berl.) 39, 13–22 (1974)Google Scholar
  19. Rushton, R., Steinberg, H.: Combined effects of chlordiazepoxide and dexamphetamine on activity of rats in an unfamiliar environment. Nature (Lond.) 211, 1312–1313 (1966)Google Scholar
  20. Rushton, R., Steinberg, H.: Drug combinations and their analysis by means of exploratory activity in rats. In: Neuropsychopharmacology, H. Brill, J. O. Cole, P. Deniker, H. Hippius, and P. B. Bradley, eds., pp. 464–470. Amsterdam: Excerpta Medica 1967Google Scholar
  21. Rushton, R., Steinberg, H., Tomkiewicz, M.: Effects of chlordiazepoxide alone and in combination with amphetamine on animal and human behavior. In: The benzodiazepines, S. Garattini, E. Mussini, and L. O. Randall, eds., pp. 355–366. New York: Raven 1973Google Scholar
  22. Sansone, M.: Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice. Psychopharmacologia (Berl.) 41, 117–121 (1975a)Google Scholar
  23. Sansone, M.: Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice. Arch. Int. Pharmacodyn. 215, 190–196 (1975b)Google Scholar
  24. Sansone, M.: Benzodiazepines and amphetamine on avoidance behaviour in mice. Arch. Int. Pharmacodyn. 218, 125–132 (1975c)Google Scholar
  25. Sethy, V. H., Naik, P. Y., Sheth, U. H.: Effect of d-amphetamine sulphate in combination with CNS depressants on spontaneous motor activity of mice. Psychopharmacologia (Berl.) 18, 19–25 (1970)Google Scholar
  26. Sulser, F., Bass, A. D.: Pharmacodynamic and biochemical considerations on the mode of action of reserpine-like drugs. In: Psychopharmacology. A review of progress 1957–1967, D. H. Efron, ed., Public Health Service Publication No. 1836, pp. 1065–1075. Washington, D.C.: Public Health Service 1968Google Scholar
  27. Valzelli, L.: Activity of benzodiazepines on aggressive behavior in rats and mice. In: The benzodiazepines. S. Garattini, E. Mussini, and L. O. Randall, eds., pp. 405–417. New York: Raven 1973Google Scholar
  28. van Rossum, J. M.: Mode of action of psychomotor stimulant drugs. Int. Rev. Neurobiol. 12, 307–383 (1970)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Mario Sansone
    • 1
  1. 1.Laboratorio di Psicobiologia e PsicofarmacologiaC.N.R.RomaItaly

Personalised recommendations