Abstract
Following the oral administration of a small dose of apomorphine and a therapeutic dose of chlorpromazine (separately and in combination), rats were IP injected with a small dose of apomorphine. The brain levels of dopamine, noradrenaline, serotonin, and free amino acids were determined. In addition to the partial antagonistic effect of chlorpromazine on the changes in the brain monoamines, an increase in the levels of free amino acids was observed in the brain of the rats after oral administration, and the effect of apomorphine injection was reversed in the rats which were given chlorpromazine in combination with oral apomorphine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allikmets, L. Kh., Zharkovskii, A. M., Vasar, E. E.: Antagonism between L-dopa and apomorphine in their effects on rat behavior. Byull. Eksp. Biol. Med. 87, 51–53 (1977)
Andén, N.-E., Rubenson, A., Fuxe, K., Hokfelt, T.: Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol. 19, 627–629 (1967)
Ansell, G. B., Beeson, M. F.: A rapid and sensitive procedure for the combined assay of noradrenaline, dopamine and serotonin in a single brain sample. Anal. Biochem. 23, 196–206 (1968)
Bender, D. A.: The effect of chlorpromazine on serum tryptophan, brain tryptophan uptake and brain serotonin synthesis in the rat. Biochem. Pharmacol. 25, 1743–1746 (1976)
Buus Lassen, J.: Inhibition of apomorphine-induced hypermotility in rats by chlorpromazine, perphenazine, thioridazine and melperone. Acta Pharmacol. Toxicol. (Kbh.) 40, 418–429 (1977)
Carlsson, A.: Receptor-mediated control of dopamine metabolism. In: Pre- and postsynaptic receptors, E. Usdin, W. E. Bunney, Jr., eds., pp. 48–65. New York: Marcel Dekker 1975
Creese, I., Manian, A. A., Prosser, T. D., Snyder, S. H.: 3H-Haloperidol binding to dopamine receptors in rat corpus striatum: Influence of chlorpromazine metabolites and derivatives. Eur. J. Pharmacol. 47, 291–296 (1978)
Curtis, D. R., Johnston, G. A. R.: Amino acid transmitters In: Handbook of neurochemistry, A. Lajtha, ed., pp. 115. New York: Plenum 1970
Dadkar, N. K., Dohadwalla, A. N., Bhattacharva, B. K.: The involvement of serotoninergic and noradrenergic systems in the compulsive gnawing in mice induced by imipramine and apomorphine. J. Pharm. Pharmacol. 28, 68–69 (1976)
Dray, A., Straughan, D. W.: Synaptic mechanisms in the substantia nigra. J. Pharm. Pharmacol. 28, 400–405 (1976)
Grabowska, M.: The involvement of serotonin in the mechanism of central action of apomorphine. Pol. J. Pharmacol. Pharm. 26, 389–394 (1976)
György, L., Deda, M.: Influence of apomorphine on sympathetic neural transmission in the nictitating membrane of the cat. Arch. Int. Pharmacodyn. Ther. 226, 194–204 (1977)
Iversen, L. L.: Dopamine receptors in the brain. Science 188, 1084–1089 (1975)
Koyuncuoğlu, H., Genç, E., Güngör, M., Eroğlu, L., Sağduyu, H.: The antagonizing effect of aspartic acid on the brain levels of monoamines and free amino acids during the development of tolerance to and physical dependence on morphine. Psychopharmacology 54, 187–191 (1977a)
Koyuncuoğlu, H., Güngör, M.: The effect of chronic meprobamate treatment on brain free amino acid levels of rats. Pharmacol. Res. Commun. 5, 207–213 (1973)
Koyuncuoğlu, H., Güngör, M.: Effect of nialamide and reserpine on brain free amino acids of rats dependent on, withdrawn from morphine. Drug. Res. 25, 1762–1766 (1975)
Koyuncuoğlu, H., Sağduyu, H., Güngör, M., Eroğlu, L., Genç, E.: Antagonizing effect of aspartic acid on the development of physical dependence on and tolerance to morphine in the rat. Drug. Res. 27, 1676–1679 (1977b)
Lal, S., Feldmüller, F.: Effect of amphetamine and apomorphine on brain monoamines and behaviour in the immature and young adult rat. Arch. Int. Pharmacodyn. Ther. 218, 239–251 (1975)
Ljungberg, T., Ungerstedt, U.: Apomorphine-induced locomotion and gnawing: Evidence that the experimental design greatly influences gnawing while locomotion remains unchanged. Eur. J. Pharmacol. 46, 147–151 (1977)
Pinder, R. M., Brogden, R. N., Sawyer, P. R., Speight, T. M., Spencer, R., Avery, G. S.: Pimozide: A review of its pharmacological properties and therapeutic uses in psychiatry. Drugs 12, 1–40 (1976)
Puech, A. J., Francés, H., Simon, P.: Imipramine antagonism of apomorphine-induced hypothermia: A non-dopaminergic interaction. Eur. J. Pharmacol. 47, 125–127 (1978)
Roth, R. H., Nowycky, M. C.: Dopaminergic neurons: Effects elicited by γ-hydroxybutyrate are reversed by picrotoxin. Biochem. Pharmacol. 26, 2079–2082 (1977)
Saifer, A.: Comparative study of various extraction methods for quantitative determination of free amino acids from brain tissue. Anal. Biochem. 40, 412–423 (1971)
Steinsland, O. S., Hieble, J. P.: Dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms. Science 199, 443–445 (1978)
Strömbom, U.: Antagonism by haloperidol of locomotor depression induced by small doses of apomorphine. J. Neural Transm. 40, 191–194 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Koyuncuoğlu, H., Atamer-Şimşek, Ş. & Keyer-Uysal, M. Effects of continuous and acute administration of small doses of apomorphine, alone or in combination with chlorpromazine, on the brain monoamines and free amino acid levels in the rat. Psychopharmacology 66, 171–177 (1979). https://doi.org/10.1007/BF00427626
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00427626