Summary
By applying biochemical, histochemical and electron microscopical methods the authors studied the effect of the whole body vertical sinusoidal vibration (100 Hz 0,1 mm) on rat liver. The activity of SDH and ATP-ase was significantly decreased, whereas the G1-6-PDH and LDH was markedly increased in liver homogenates and kryostate slices. Certain abnormalities concerning the number, size and internal organization of the mitochondria were observed. The data revealed by the biochemical, histochemical and ultrastructural study show the possibility of involvement of liver tissue in vibration caused damages.
Similar content being viewed by others
References
Abramovich-Poljakov, D.K., Gunko, M.V., Perly, O.N.: Some indices of the energetic turnover with vibration diseases. Gig. truda i profzabol. 8, 34–36 (1974) (in Russian)
Andreeva-Galanina E. Ts., Dolgova, M.A., Jakubovich, T.G.: The effect of the whole-body vertical vibration on the vascular stream of the liver. Gig. truda i profzabol. 12, 22–24 (1971) (in Russian)
Chramov, J.A.: Peculiarities of glucose consumption, lactic and pyruvic acid in persons exposed to vibration. Gigiena i sanitaria 1, 110–112 (1975) (in Russian)
Ivanovich, E.: Experimental investigation on the changes in rat kidney, due to whole body vibration. Dissertation, Sofia (1970)
Ivanovich, E., Zlateva, M.: Dynamics of recovery processes in rat liver under the effect of low-frequency vibrations. Proceed. Regional Symposium on Noise and Vibration Abatement of the COPISEE Member-countries. Varna 30.10-1.11, 1971, p. 31–35
Ivanovich, E., Krastev, L.: Ultrastructural changes in rat liver due to wholebody vibration and physical loading. Proceed. Regional Symposium on Noise and Vibration Abatement of the COPISEE Member-countries. Varna, 14–18.10.1975
Karpova, N., Kordykov, N., Ivanova, V.: The effect of local vibration on the blood vessels and peripheral nerves. Gig. truda i profzabol. 18/8, 4–7 (1974)(in Russian)
Kirk, J., Laursen, T.: Dehydrogenase activities of human aortic tissue determined with triphenyl tetrazolium technique. J. of Gerontol. 10, 1, 18–25 (1955)
Kiseleva, B.P., Bulachenko, L.S.: Disturbance in some indices of protein metabolism after a prolonged vibration effect. Gig. truda i profzabol. 8, 38–41 (1974) (in Russian)
Lind, H.: About the activity of urease and ATP-ase in subcellular fractions of ventricular mucosis. Biochimija, Moscow, 29, 2, 191 (1964) (in Russian)
Miclesco-Groholsky, S., Anitesco, C.: Variations de l'anylasarie de l'amylasemie sous l'effet du “stress” sonore et vibratoire dans l'industrie. Arch. Mal. Prof. 31, 6 277–282 (1970)
Molchanov, B.P., Solun, B.S.: Changes in the protein metabolism in vibration disease. Gig. truda i profzabol. 10, 43–45 (1971) (in Russian)
Mori, M.: Histochemical evaluation of NAD-P-dependent glucose-6-phosphate and isocitrate dehydrogenases in steroid producing organs and tumors. Arch. Histol. Jap. 28, 45–57 (1967)
Nachlas, M.M., Tsou, L.C., Souza, E.D., Cheng, C.S., Seligman, A.M.: Cytochemical demonstration of succinic dehydrogenase by use of a new p-nitrophenyl substituted ditetrazole, J. Histochem., Cytochem. 5, 420–436 (1957)
Padykula, A.A., Herman, E.: Factors affecting the activity of ATP-ase and other phosphatases as measured by histochemical techniques. J. Histochem. Cytochem. 3, 161–169 (1955)
Pogodaev, K.T., Turova, N.P.: in “Brain biochemistry under fatigue and exhaustion”. Moscow: Medicina 1972 (in Russian)
Sass, D.J.: Mechanisms of injury due to intense ± Gz vibration in waterimmersed cats. J. App. Physiol. 26,6, 819–826 (1969)
Slateva, M., Ivanovich, E., Antov, G.: Histological and enzymic investigation in rat liver due to vibration. Higiena i zdraveopazvane XIV, 2, 161–166 (1971) (in Bulgarian)
Sobol, J.M., Jenin, J.P.: Electron microscopic changes in the Cochlea after exposure to whole body vibration and noise. Zh. Ushn. Nos. Gorl. Bolezn, 32/6, 43–48 (1972)
Tsvetkov, D.L., Hadzieva, I., Calbourova, F., Georgieva, I.: Modifications de certains indices de l'oxydation biologique et de la phosphorylation sous l'influence de vibrations experimentales de haute frequence. Int. Arch. Occup. Environm. Hlth. 35, 265–277 (1975)
Tsvetkov, D.L., Popov, T.: The effect of high-frequency vibration on the activity of some enzymes participating in biological oxidation in experiment. J. Hygiene, Epidemiology, Microbiol. Immunil. 17, 169–175 (1973)
Tambovtseva, A.M.: The effect of vibration and noise on protein metabolism in excavator operators judging by certain biochemical indices. Gig. i sanitaria 1, 58–61 (1968) (in Russian)
Verzilova, O.V., Rodnikov, A., Razbash, F.L.: Impact of prolonged continuous and interrupted exposure to general vertical vibration on human organism. Biul. Inst. Med. Morsk. Gdansk. 25/2-3-4, 375–378 (1974)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ivanovich, E., Antov, G. & Kazakova, B. Enzymic and ultrastructural changes in rat liver due to whole body vibration. Int. Arch Occup Environ Heath 39, 249–254 (1977). https://doi.org/10.1007/BF00409370
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00409370