Summary
In a behavior study of a sexually deviant XYY and XXY male, who were both murderers, plasma noradrenalin (NA), dopamine-beta-hydroxylase (DBH) were determined radioenzymatically under resting conditions and during exertional and emotional stress. Under a physical work load on the bicycle ergometer both had normal plasma NA and DBH levels. During emotional stress both had NA increases of the same magnitude. During an arithmetic test NA values did not increase more than expected for the sitting position.
Disturbed NA function does not seem to be the cause of the behavior disorder of the XYY and XXY patients.
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Henry, D. P., Starman, B. J., Johnson, D. G., Williams, R. H.: A sensitive radioenzymatic assay for norepinephrine in tissues and plasma. Life Sci. 16, 375–384 (1975)
Hunter, H.: A controlled study of the psychopathology and physical measurements of Klinefelter Syndrome. Brit. J. Psychiat. 115, 443–448 (1969)
Kozłowski, S., Brzezinska, Z., Nazar, K., Kowalski, W., Franczyk, M.: Plasma catecholamines during sustained isometric exercise. Clin. Sci. Mol. Med. 45, 723–731 (1973)
Lake, C. R., Ziegler, M., Kopin, I. J.: Human plasma norepinephrine: I. Variation in normal subjects. Neurosciences Abstracts, 5th Annual Meeting, New York, N.Y., p. 413, 1975
Lake, R., Ziegler, G., Kopin, J.: Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man. Life Sci. 18, 1315–1326 (1976)
Money, J., Annecillo, C., van Orman B., Borgaonkar, D. S.: Cytogenetics, hormones and behavior disability: comparison of XYY and XXY syndromes. Clin. Genet. 6, 370–382 (1974)
Money, J., Wiedeking, C., Walker, P., Migeon, C., Meyer, W., Borgaonkar, D.S.: 47,XYY and 46,XY males with antisocial and/or sex-offending behavior: antiandrogen therapy plus counseling. Psychoneuroendocrinology 1, 165–178 (1975)
Noël, B., Duport, J. P., Revil, D., Dussuyer, I., Quack, B.: The XYY syndrome: reality or myth? Clin. Genet. 5, 387–394 (1974)
Planz, G., Wiethold, G., Appel, E., Böhmer, D., Palm, D., Grobecker, H.: Correlation between increased dopamine-beta-hydroxylase activity and catecholamine concentration in plasma: Determination of acute changes in sympathetic activity in man. Europ. J. clin. Pharmacol. 8, 181–188 (1975)
Schachter, S., Singer, J. E.: Cognitive, social, and physiological determinants of emotional state. Psychol. Rev. 69, 379–399 (1962)
Weinshilboum, R. M., Axelrod, J.: Serum dopamine-beta-hydroxylase activity. Circulat. Res. 28, 307–315 (1971)
Weinshilboum, R. M., Schrott, H. G., Raymond, F. A., Weidman, W. H., Elveback, L.R.: Inheritance of very low serum dopamine-β-hydroxylase activity. Amer. J. hum. Genet. 27, 573–585 (1975)
Wiedeking, C., Lake, C. R., Ziegler, M., Kowarski, A. A., Money, J.: Plasma noradrenaline and dopamine-beta-hydroxylase during sexual activity. Psychosom. Med. 39, 143–148 (1977)
Ziegler, M., Lake, C. R., Foppen, F. H., Kopin, I. J., Shoulson, I.: Norepinephrine in cerebrospinal fluid. Brain Res. 108, 436 (1976)
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Part of the described results were obtained during the work for her medical thesis by E.M.
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Wiedeking, C., Lake, C.R., Ziegler, M. et al. Plasma noradrenalin and dopamine-beta-hydroxylase during behavioral testing of sexually deviant XYY and XXY males. Hum Genet 37, 243–247 (1977). https://doi.org/10.1007/BF00393589
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DOI: https://doi.org/10.1007/BF00393589