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Profile of the Plasma Catecholamines of Sexually Mature Rats Exposed to a Combination of Factors of Different Natures

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Abstract

Changes in the catecholamines concentration in plasma depend on the rhythm of the external light signal. Light desynchronosis has the strongest influence on the change in the dopamine concentration in the blood plasma. The combined effect of the physical factor, i.e., prolonged changes in the light regimen, and the chemical factor (single, acute poisoning with a neurotoxicant) results in the activation of exogenous and endogenous pathways for the regulation of the biological rhythms of catecholamine secretion into the blood plasma. The most pronounced changes were observed in blackout conditions.

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ACKNOWLEDGMENTS

The author acknowledges Doctor of Medicine, Associate Professor V.A. Kashuro, the Head of the Laboratory of Biochemical Toxicology and Pharmacology of Golikov Research Center of Toxicology, Russia, and Doctor of Medicine, Associate Professor M.B. Ivanov for significant comments and valuable advice in the conduction of the experiment and the formatting of the article.

Funding

The study was conducted at the Golikov National Center of Cardiology and Therapy within the government contract on the research topic, “Development of approaches to the management of functional state impairments upon neurointoxication under changes of light regimens.” The state registration number for Research, Development, and Technological Work is АААА-А18-118031290067-6.

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Authors and Affiliations

  1. Golikov Research Center of Toxicology, Federal Medical Biological Agency, 192019, St. Petersburg, Russia

    E. G. Batotsyrenova

  2. St. Petersburg State Pediatric Medical University, 194100, St. Petersburg, Russia

    E. G. Batotsyrenova

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  1. E. G. Batotsyrenova
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Correspondence to E. G. Batotsyrenova.

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Conflict of interests. The author declares that she has no conflict of interests.

Statement on animal welfare. The animals were managed in accordance with the “Principles of Good Laboratory Practice” of the All-Union State Standard requirements, no. 33044-2014, August 1, 2015. The rules and norms of humane management of experimental animals were followed during the experiments. All animal experiments were performed in correspondence with the “Guide for the Care and Management of Laboratory Animals. Rules of Care and Management of Laboratory Rodents and Rabbits” and “Guide for the Care and Management of Laboratory Animals. Rules of Interior Equipment and Procedure Organization,” All-Union State Standard requirements no. 33216-2014 and 33215-2014, respectively.

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Translated by E. Sherstyuk

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Batotsyrenova, E.G. Profile of the Plasma Catecholamines of Sexually Mature Rats Exposed to a Combination of Factors of Different Natures. Adv Gerontol 11, 132–138 (2021). https://doi.org/10.1134/S207905702102003X

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  • DOI: https://doi.org/10.1134/S207905702102003X

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