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Mutagenicity of aflatoxin B1, activated by S-9 fractions of human, rat; mouse, rabbit, and monkey liver, towards s. typhimurium TA 98

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Summary

A comparison was made of the mutagenicity of AFB, by rat, rabbit, mouse, and monkey liver preparations with that of human liver in the Salmonella/microsome assay using S. typhimurium TA98 as the indicator strain. Equal liver protein concentrations (l.2 mg/plate) were used to determine the number of his+ revertants per nmole of AFB1 induced. These values were for rat, rabbit, mouse, Green monkey and human liver preparations, 573±27, 480±22, 269±8, 233±21 and 36±4, respectively.

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Authors and Affiliations

  1. Institut für Staublungenforschung und Arbeitsmedizin der Westfälischen Wilhelms-Universität Münster, D-4400, Münster, Germany

    K. Norpoth

  2. Hygiene-Institut der Westfälischen Wilhelms-Universität Münster, D-4400, Münster, Germany

    R. Grossmeier & H. Bösenberg

  3. Lehrstuhl für medizinische Cytobiologie und Elektronenmikroskopie der Medizinischen Fakultät der Westfälischen Wilhelms-Universität Münster, D-4400, Münster, Germany

    H. Themann & M. Fleischer

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Norpoth, K., Grossmeier, R., Bösenberg, H. et al. Mutagenicity of aflatoxin B1, activated by S-9 fractions of human, rat; mouse, rabbit, and monkey liver, towards s. typhimurium TA 98. Int. Arch Occup Environ Heath 42, 333–339 (1979). https://doi.org/10.1007/BF00377788

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