Abstract
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1.
The intestinal excretion of hexachlorobenzene (HCB) was studied in rats using the method of pendular perfusion. One and four weeks after i.p. application of 100 mg HCB/kg body weight segments of jejunum, ileum and colon were perfused with light liquid paraffin or squalane for 5 h.
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2.
The highest amount of HCB was excreted into jejunum, followed by ileum and colon. After 5 h HCB concentration in jejunal perfusion medium equals that in plasma.
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3.
Serosal tissue of intestinal segments contained higher HCB concentrations as compared to mucosa.
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4.
Paraffin treatment decreased the HCB content in both serosal and mucosal tissue of jejunum and ileum but not of colon.
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Abbreviations
- HCB:
-
hexachlorobenzene
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Richter, E., Schäfer, S.G. Intestinal excretion of hexachlorobenzene. Arch Toxicol 47, 233–239 (1981). https://doi.org/10.1007/BF00368683
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DOI: https://doi.org/10.1007/BF00368683