Abstract
In acute oral studies, the effect of bromobenzene on hepatic microsomal enzymes was investigated. Neither glucuronyltransferases nor cytochrome c reductase showed significant changes. Most of the mixed-function oxidases studied were inhibited with the exception of ketamine-N-demethylase. The data indicate that bromobenzene or its epoxide acts on cytochrome P-450 but not on all cytochrome P-450 species, and does not affect the reductase and the glucuronyltransferases. Microsomal lipoperoxidation and microsomal H2O2 formation were increased.
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Dedicated to Prof. R. Sammet on occasion of his 60th birthday
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Beyhl, F.E., Mayer, D.G. Studies on liver toxicants. Arch. Toxicol. 43, 257–262 (1980). https://doi.org/10.1007/BF00366181
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DOI: https://doi.org/10.1007/BF00366181