Summary
Isolated rat papillary muscles were stimulated electrically in a 50 ml. Tyrode bath at 37°C. Potentiation of contractile force following a period of rest and post-stimulation potentiation were studied.
A potentiation of contractile force increased with an increase in the period of rest up to 32 secs. Post-stimulation potentiation was observed following short periods of high frequency stimulation. The changes in the duration of stimulation (from 7,5 up to 60 secs.) had no significant influence on the degree of post-stimulation potentiation. An increase in frequency of stimulation (from 10 to 40 per sec.) caused an increase in post-stimulation potentiation.
The possibility of a release of a “post-stimulation substance” is discussed. It is suggested that such a hypothetical substance may be pharmacologically similar to sympathomimetic amines.
The “Treppe” phenomenon in isolated papillary muscles of cats and rats is different, when the potentiation of contractile force following a period of rest and post-stimulation potentiation are similar in both species. It is therefore suggested that different mechanisms may be responsible for these phenomena.
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Scriabine, A. Über die Änderung der Kontraktionsamplitude des elektrisch gereizten Rattenpapillarmuskels nach einer Reizpause oder einer Periode hochfrequenter Reizung. Pflügers Archiv 269, 311–318 (1959). https://doi.org/10.1007/BF00362201
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DOI: https://doi.org/10.1007/BF00362201