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Untersuchungen zum Metabolismus des Carbromal

Investigations of carbromal metabolism

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Abstract

Erythro-2-Brom-2-ethyl-3-hydroxybutyramide has been isolated from the urines of patients with Carbromal intoxications as well as from the urine of rat, mouse and dog treated with either Carbromal or with 2-Brom-2-ethylacetamide. The identification of the excreted and synthetized metabolite was carried out by means of IR, Mass and NMR spectroscopy.

Along with the erythro-2-Brom-2-ethyl-3-hydroxybutyramide one other bromine containing compound was isolated after Carbromal application only, its mass spectrum and rel. RF values having the same characteristics as the synthetized erythro-2-Brom-2-ethyl-3-hydroxybutyrylcarbamide. However, the purification of this metabolite so far has not been successful.

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References

  • Bäumler, J., Ripstein, S.: Über den Nachweis von Carbromal (Adalin) und dessen Metaboliten. Arch. Pharm. 296, 301 (1963)

    Google Scholar 

  • Butler, T. C.: The metabolic fate of carbromal (2-bromo-2-ethyl-butyrylurea). J. Pharmacol. exp. Ther. 143, 23 (1964)

    Google Scholar 

  • Käferstein, H., Detmer, J., Sticht, G.: Empfindlicher dünnschicht-chromatographischer Nachweis der Bromharnstoffderivate in Körperflüssigkeit. Z. klin. Chem. 12, 178 (1974)

    Google Scholar 

  • Narafu, T.: Studies on debromination of α-bromacylureides in vivo. J. Pharm. Soc. Japan 87, 357 (1967)

    Google Scholar 

  • Schmidt, G.: Vorkommen und Ausscheidung von α-Äthyl-α-Oxybuttersäure nach Adalinaufnahme. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 229, 67 (1956)

    Google Scholar 

  • Schwetlick, K.: Organikum, Organisch-chemisches Grundpraktikum, 9. Aufl. Berlin: VEB Dtsch. Verl. Wiss. 1969

    Google Scholar 

  • Sticht, G., Käferstein, H.: Untersuchungen zur Metabolisierung von Bromharnstoffderivaten. 1. Mitteilung: In vitro Abbau von Carbromal und Acetylcarbromal in der Kaninchenleber. Arzneimittel-Forsch. 23, 1021 (1973)

    Google Scholar 

  • Sticht, G., Käferstein, H.: Strukturnachweis von bromhaltigen Carbromalmetaboliten. Arch. Toxicol. 35, 263 (1976)

    Google Scholar 

  • Tamminen, V., Alha, A. R.: 2-Ethylbutyrylurea, a metabolite of 2-bromo-2-ethyl-butyrylurea (Carbromal, Adalin). Suom. Kemistilehti B 32, 119 (1959)

    Google Scholar 

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Hamburg, Martinistraße 52, D-2000, Hamburg 20, Bundesrepublik Deutschland

    W. Zimmermann & W. Braun

Authors
  1. W. Zimmermann
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  2. W. Braun
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Additional information

Auszugsweise vorgetragen auf der 18. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, 16.–18. März 1977

Herrn Dipl.-Physiker Dr. Moser von der Unilever-Forschungsgesellschaft mbH, Hamburg, gilt unser besonderer Dank für die Aufnahme der Massen- und NMR-Spektren.

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Zimmermann, W., Braun, W. Untersuchungen zum Metabolismus des Carbromal. Arch. Toxicol. 38, 287–294 (1977). https://doi.org/10.1007/BF00352033

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  • DOI: https://doi.org/10.1007/BF00352033

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