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Acid-Base Properties of 6-Methyluracil-5-carbonitrile and Its N-Methyl Derivatives

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Abstract

The constants of acid-base equilibrium of 6-methyluracil-5-carbonitrile in water were determined spectrophotometrically. For the first time, 1,6-dimethyluracil-5-carbonitrile and 3,6-dimethyluracil-5-carbonitrile were obtained, their structures were proved by 1H, 13C, and 15N NMR spectroscopy. Based on the pKa values obtained for all three compounds, the sequence of dissociation in the 6-methyluracil-5-carbonitrile molecule in alkaline aqueous solutions was determined.

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Funding

The work was carried out within the framework of the state assignments of the Ministry of Science and Higher Education (nos. AAAA-A20-120012090029-0 and AAAA-A20-120012090026-9) using the equipment of the Chemistry and Agidel Shared Use Centers of the Ufa Federal Research Center of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, 450054, Ufa, Russia

    A. A. Akhiyarov, A. N. Lobov, I. B. Chernikova & S. P. Ivanov

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  1. A. A. Akhiyarov
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  2. A. N. Lobov
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  3. I. B. Chernikova
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  4. S. P. Ivanov
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Correspondence to S. P. Ivanov.

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Akhiyarov, A.A., Lobov, A.N., Chernikova, I.B. et al. Acid-Base Properties of 6-Methyluracil-5-carbonitrile and Its N-Methyl Derivatives. Russ J Gen Chem 92, 154–160 (2022). https://doi.org/10.1134/S1070363222020037

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