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LD50 versus acute toxicity

Critical assessment of the methodology currently in use

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Conclusions

Based on today's extensive experience on acute toxicity testing of chemical substances, and on the outcome of specific studies (Schütz and Fuchs 1982; Müller and Kley 1982; Lorke in preparation; Günzel et al. in preparation), it is now possible to conduct acute toxicity studies with the sacrifice of fewer animals and even to increase at the same time, the quality of the data obtained. Whereas for drugs, data on acute toxicity usually represents only part of the information available, for other chemical substances, acute toxicity may be the only data available, thus asking for more extensive examination of the animals used 'for this kind of study.

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References

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Authors and Affiliations

  1. Institut für Arzneimittel des Bundesgesundheitsamtes, Postfach, D-1000, Berlin 33

    R. Baß

  2. Abteilung für Experimentale Toxikologie, Pharma Forschung/FB III, Schering AG, D-1000, Berlin 65

    P. Günzel

  3. Institut für Pharmakologie und Toxikologie der Universität, Versbacher Landstrasse 9, D-8700, Würzburg

    D. Henschler

  4. Byk Gulden Pharmazeutika, Institut für Pathologie und Toxikologie, Friedrich-Ebert-Damm 101, D-2000, Hamburg 70

    J. König

  5. Institut für Toxikologie, BAYER AG, D-5600, Wuppertal 1

    D. Lorke

  6. Institut für Toxikologie u. Embryopharmakologie, Freie Universität, Garystrasse 9, D-1000, Berlin 33

    D. Neubert

  7. Abt. für Toxikologie, HOECHST AG, D-6230, Frankfurt am Main 80

    E. Schütz

  8. c/o Bundesverband der Pharmazeutischen Industrie E. V., Karlstrasse 21, D-6000, Frankfurt am Main 1, Germany

    D. Schuppan

  9. Institute of Toxicology, Swiss Federal Institute of Technology and University of Zürich, Schwerzenbach, Switzerland

    G. Zbinden

Authors
  1. R. Baß
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  2. P. Günzel
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  3. D. Henschler
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  4. J. König
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  5. D. Lorke
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  6. D. Neubert
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  7. E. Schütz
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  8. D. Schuppan
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  9. G. Zbinden
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Baß, R., Günzel, P., Henschler, D. et al. LD50 versus acute toxicity. Arch Toxicol 51, 183–186 (1982). https://doi.org/10.1007/BF00348850

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  • DOI: https://doi.org/10.1007/BF00348850

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