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Examination of Acute and Chronic Toxicity

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Regulatory Toxicology

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Abstract

Determination of the toxicological profile is necessarily related to the toxicity of a substance considering risk potential/risk estimation for human. Essential relevance includes the dose level as well as the application period. Studies considering acute, subacute, subchronic, and chronic intake are the basic which can be enlarged by specified studies. In general the results of those studies are relevant to set characteristic (LD 50/LC50 values, MOS, AOEL, ADI).

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Recommended Reading

  • Diener W, Siccha L, Mischke U, Kayser D, Schlede E (1994) The biometric evaluation of the acute-toxic-class method (oral). Arch Toxicol 68(10). Springer Verlag, Heidelberg

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  • Niesink RJM, de Vries J, Hollinger MA (1996) Toxicology: principles and applications. CRC Press, Boca Raton

    Google Scholar 

Resources

  • OECD Guidelines for Testing of Chemicals (1981 ff), OECD Publication Service, Paris, Web address: www.oecd.org

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Author information

Authors and Affiliations

  1. Expert Regulatory Toxicology, Bensberger Marktweg 363, 51069, Köln, Germany

    Karl Georg Heimann

  2. Product Stewardship Manager, Bayer CropScience, Registration Department, Alfred Nobel-Straße, 40789, Monheim, Germany

    Kevin Doughty

Authors
  1. Karl Georg Heimann
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  2. Kevin Doughty
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Corresponding author

Correspondence to Karl Georg Heimann .

Editor information

Editors and Affiliations

  1. Walther-Straub-Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany

    Franz-Xaver Reichl

  2. Formerly Medical School, Hannover, Germany

    Michael Schwenk

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© 2014 Springer-Verlag Berlin Heidelberg

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Heimann, K.G., Doughty, K. (2014). Examination of Acute and Chronic Toxicity. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35374-1_31

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