Abstract
Female Sprague-Dawley rats received phenacetin or aspirin at average daily doses of 135 and 27 mg/kg respectively in the diet and either demineralized water (DMW) or a 100 ppm cadmium (Cd) solution as their drinking water for 12 months. This dose of Cd produced borderline tubular toxicity, as measured by the excretion of IV-injected human β 2-microglobulin. The kidney accumulation of Cd just reached the critical level of 200 ppm in all groups at the end of the study. The various treatments did not significantly affect growth, creatinine clearance, urine osmolality and the urinary excretion of β-N-acetyl-d-glucosaminidase and aminoacids. No interaction resulted from the concomitant administration of analgesics and Cd. Both aspirin subgroups (receiving DMW or Cd) showed an attenuation of the age-related decline of the renal function as revealed by a lower urinary excretion of albumin and total protein. The accentuation of the mesangial matrix seen upon aging was also partly inhibited in the aspirin rats.
Similar content being viewed by others
References
Autor AP (editor) (1982) Pathology of oxygen. Academic Press Inc., New York
Axelsen RA (1980) Nephrotoxicity of Mild Analgesics in the Gunn Strain of Rats. Br J Clin Pharmacol 10: 309 S-312 S
Bernard A (1980) Evaluation of renal dysfunction induced by cadmium in man by determination of enzymes and specific proteins in urine. Arch Toxicol [Suppl] 4: 223–232
Bernard A, Buchet JP, Roels H, Masson P, Lauwerys R (1979) Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur J Clin Invest 9: 11–22
Bernard A, Roels H, Hubermont G, Buchet JP, Masson PL, Lauwerys R (1976) Characterization of the proteinuria in cadmium-exposed workers. Int Arch Occup Environ Health 38: 19–30
Bernard A, Viau C, Lauwerys R (1983) Renal handling of human β 2-microglobulin in normal and cadmium-poisoned rats. Arch Toxicol 53: 49–57
Briggs D, Calder I, Woods R, Tange J (1982) The influence of metabolic variation on analgesic nephrotoxicity. Experiments with the Gunn rat. Pathology 14: 349–354
Friberg L, Piscator M, Nordberg GF, Kjellstrom T (1974) Cadmium in the environment. CRC Press, Cleveland, Ohio 114
Gray JE (1977) Chronic progressive nephrosis in the albino rat. CRC Crit Rev Toxicol 5: 115–144
Harman D (1981) The aging process. Proc Natl Acad Sci USA 78: 7124–7128
Lauwerys R, de Wals Ph (1981) Environmental pollution by cadmium and mortality from renal diseases. Lancet 383
Leaback DH, Walker PG (1961) Studies on glucosaminidases. 4. The fluorimetric assay of N-acetyl-β-glucosaminidase. Biochem J 78: 151–156
Roels HA, Lauwerys RR, Buchet JP, Bernard A (1981) Environmental exposure to cadmium and renal function of aged women in three areas of Belgium. Environ Res 24: 117–130
Rosner I (1976) Experimental analgesic nephropathy. CRC Crit Rev Toxicol 4: 331–352
Spühler O, Zollinger HU (1953) Die Chronisch-interstitielle Nephritis. Z Klin Med 151: 1–50
Viau C, Bernard A, Lauwerys R, Tulkens P, Laurent G, Maldague P (1983) Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats. Toxicology 27: 15–25
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Viau, C., Bernard, A., Lauwerys, R. et al. Cadmium, analgesics, and the chronic progressive nephrosis in the female Sprague-Dawley rat. Arch Toxicol 55, 247–249 (1984). https://doi.org/10.1007/BF00341019
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00341019