Abstract
Complete separation of phenol, o-, m- and p-cresol was achieved by capillary gas-chromatography. Urinary concentrations of cresols were determined quantitatively in samples from 10 male workers exposed to toluene. Besides pcresol, o- and m-cresol were found to be urinary compounds in the case of the exposed group in contrast to normal persons. This finding was proved by gas-chromatography/mass spectrometry. The difference between both groups is significant. It is concluded that besides hippuric acid o-, m- and p-cresol are metabolites of toluene.
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Woiwode, W., Wodarz, R., Drysch, K. et al. Metabolism of toluene in man: gas-chromatographic determination of o-, m- and p-cresol in urine. Arch Toxicol 43, 93–98 (1979). https://doi.org/10.1007/BF00333615
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DOI: https://doi.org/10.1007/BF00333615