Summary
An analysis of the computed tomograms of 18000 children examined consecutively form the basis of an assessment of the diagnostic significance of intracranial calcification. The low incidence of physiological calcification in the pineal and choroid of about 2% up to the age of 8 years, but increasing 5-fold by the age of 15 years, is confirmed. Pathological calcification occurred in 1.6%, the commonest causes being neoplasms (43%), neuroectodermal syndromes (20%) and infections (12%). Diffuse basal ganglia calcification (15%) bore little relation to the diverse clinical symptomatology, and routine biochemical studies showed a disorder of metabolism to be present in only 6 cases. Calcification has not been previously noted in acute haemorrhagic leukoencephalitis, Pertussis or Cocksackie encephalitis, infantile neuraxonal dystrophy, Marinesco-Sjögren syndrome or in the basal ganglia in neurofibromatosis.
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References
Harwood-Nash DC, Fitz CR (1976) Neuroradiology in infants and children. CV Mosby, St. Louis, pp 163–164
Modic MT, Weinstein MA, Rothner AD, Erenberg G, Duchesneau PM, Kaufman B (1980) Calcification of the choroid plexus visualised by computed tomography. Radiology 135: 369–372
Zimmermann RA, Bilaniuk LT (1982) Age related incidence of pineal calcification detected by computed tomography. Radiology 142:659–662
Levin S, Robinson RO, Aicardi J, Hoare RD (1984) Computed tomography appearances in the linear sebaceous naevus syndrome. Neuroradiology 26:469–472
Meenan FOC, Bowe SD, Dinn JJ, McCabe M, McCullen O, Masterson JG, Towers RP (1978) Lipoid proteinosis: A clinical, pathological and genetic study. Q J Med 47:549–561
Leonard JN, Ryan TJ (1981) CT scan appearances in a patient with lipoid proteinosis. Br J Radiol 54:1098–1100
Wesenberg RL, Juhl JH, Daube JR (1966) Radiological findings in lissencephaly (congenital agyria). Radiology 87: 436–444
Illum F, Dupont E (1985) Prevalences of CT-detected calcification in the basal ganglia in idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neuroradiology 27:32–37
Dubois PJ, Freemark M, Lewis D, Drayer BD, Heinz ER, Osborne D (1981) Atypical findings in adrenoleukodystrophy. J Comput Assist Tomogr 5:888–891
Kwan E, Drace J, Enzmann D (1984) Specific CT findings in Krabbe disease. Am J Neuroradiol 5:453–458
Harrington MG, Macpherson P, McIntosh WB, Allan BF, Bone I (1981) The significance of incidental finding of basal ganglia calcification on computerised tomography. J Neurol Neurosurg Psychiatry 44:1168–1170
Wisniewski KE, French JH, Rosen JF, Kozlowski PB, Tenner M, Wisniewski HM (1982) Basal ganglia calcification (BGC) in Down's syndrome (DS) — another manifestation of premature aging. Ann NY Acad of Sci 396:179–189
Hammerton W (1982) A tapetoretinal degeneration with symmetrical calcification of the basal ganglia. A hereditary disease. Eur Neurol 21:249–255
Oppenheimer DR (1984) Diseases of the basal ganglia, cerebellum and motor neurones. In: Adam JH, Corsellia JAN, Duchen LW (eds) Greenfield neuropathology, 4th edn Ed. Arnold, London
Smith I, Hyland K (1985) Clinical role of pteridine therapy in tetrahydrobiopterin deficiency. J Inherited Metab Dis 8
Peylan-Ramu N, Poplack DG, Blei CL, Herdt JR, Vermess M, Di Chiro G (1977) Computer assisted tomography in methotrexate encephalopathy. J Comput Assist Tomogr 1:216–221
Smith D, Bloch S, Al-Raschid RA (1980) Basal ganglia calcification on CT scanning in children with acute lymphocytic leukemia. Neuroradiology 20:91–93
Norman MG, Becker LE (1974) Cerebral damage in neonates resulting from arteriovenous malformation of the vein of Galen. J Neurol Neurosurg Psychiatry 37:252–258
Cohen CR, Duchesneau PM, Weinstein MA (1980) Calcification of the basal ganglia as visualized by computed tomography. Radiology 134:97–99
Marksbery WR (1979) Lactic, acidaemia, motochondrial myopathy and basal ganglia calcification. Neurology 29: 1057–1061
Seigel RS, Seeger JF, Gabrielsen TO, Allen JA (1979) Computed tomography in oculocraniosomatic disease (Kearns-Sayre Syndrome). Radiology 130:159–164
Smyth DPL, Lake BD, MacDermott J, Wilson J (1975) In born error of carnitine metabolism (“carnitine deficiency”) in man. Lancet I:1198–1199
Dorfman LJ, Pedley TA, Thorp BR, Scheithauer BW (1978) Juvenile neuroaxonal dystrophy; clinical electrophysiological and neuropathological features. Ann Neurol 3:419–428
Baraitser M (1982) The genetics of neurological disorders. Oxford University Press, Oxford
Foley J (1951) Calcification of the corpus striatum and dentate nucleic occurring in a family. J Neurol Neurosurg Psychiatry 14:253–261
Adachi M, Wellman KF, Volk BW (1968) Histochemical studies on the pathogenesis of idiopathic non-arteriosclerotic cerebral calcification. J Neuropathol Exp Neurol 27:483–499
Moskowitz MA, Winickoff RN, Heinz ER (1971) Familial calcification of the basal ganglions; a metabolic and genetic study. N Engl J Med 285:72–77
Boller F, Boller M, Denes G, Timberlake W, Zieper I, Albert M (1973) Familial palilalia. Neurology 23:1117–1125
Strobos RRJ, de la Torre E, Martin JF (1957) Symmetrical calcification of the basal ganglia with familial ataxia and pigmentary macular degeneration. Brain 80:313–318
Cockel R, Hill EE, Rushton DI, Smith B, Hawkins CF (1973) Familial steatorrhoea with calcification of the basal ganglia and mental retardation. Q J Med 42:771–783
Aicardi J, Goutières F (1984) Progressive familial encephalopathy. Ann Neurol 15:49–54
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Kendall, B., Cavanagh, N. Intracranial calcification in paediatric computed tomography. Neuroradiology 28, 324–330 (1986). https://doi.org/10.1007/BF00333438
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DOI: https://doi.org/10.1007/BF00333438