Abstract
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1.
The excretion of Tl+-ions from blood into the lumen was investigated on the stomach and an segments of jejunum, ileum, colon ascendens, and colon descendens in situ of anesthetized rats using the pendular perfusion technique. The kidneys of the rats were tied-off. Tl+-ions were administered i.v. at the beginning of the experiments as 204Tl-(Tl2SO4). The amount of 204Tl-labeled Tl+-ions in the perfusion fluid of the gastrointestinal sections was calculated from the 204Tl concentration and the fluid volume.
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2.
Excretory activity for Tl+-ions is highest in the the jejunum; it is followed by the colon ascendens. The ileum and the colon descendens show nearly equal excretory activity which is just half of that measured in the jejunum. The amount of Tl+-ions excreted into the stomach is negligible.
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3.
At the end of the experiment in the perfusion fluid of all segments of the intestine the concentration of 204Tl is statistically significently higher than that in plasma.
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4.
In jejunal and colonic (descendens) segments the amount of Tl+-ions excreted increases with increasing i.v. doses tested from 2×10−8 up to 2×10−6 moles/kg body weight.
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References
Bray GA (1960) A simple efficient liquid scintillator for counting aqueous solution in a liquid scintillation counter. Analyt Biochem 1:279–285
Forth W, Henning CH (1979) Secretion of Tl+-ions in the stomach, the jejunum and the colon in situ of rats with increasing Tl-doses. Naunyn-Schmiedebergs Arch Pharmacol (Suppl) 307:R415
Forth W, Rummel W, Baldauf J (1968a) Wasser-und Elektrolytbewegung am Dünn-und Dickdarm unter dem Einfluß von Laxantien; ein Beitrag zur Klärung ihres Wirkungsmechanismus. Naunyn-Schmiedebergs Arch Pharmacol Exp Pathol 254: 18–32
Forth W, Rummel W, Glasner H (1968b) Zur resorptionshemmenden Wirkung von Gallensäuren. Naunyn-Schmiedebergs Arch Pharmacol Exp Pathol 254: 364–380
Frey J, Schlechter M (1939) Experimentelle Untersuchungen über die Ausscheidungsgröße des Thalliums in verschiedenen Körperflüssigkeiten. Naunyn-Schmiedebergs Arch Pharmacol Exp Pathol 193: 530–538
Gehring PJ, Hammond PB (1964) The uptake of thallium by rabbit erythrocytes. J Pharmacol Exp Ther 145:215–221
Henning CH (1979) Zum Mechanismus der Sekretion von Thallium-Ionen in den Gastrointestinal-Trakt; Untersuchungen an Ratten. Dissertation, Abt Biologie Ruhr-Universität Bochum
Henning H, Forth W (1977) Absorption and secretion of thallous ions on isolated intestinal segments in vitro of rats. Naunyn-Schmiedebergs Arch Pharmacol (Suppl) 297:R2 6
Henning CH, Forth W (1978) Secretion of thallous ions from the blood into the gastrointestinal tract of rats. Naunyn-Schmiedebergs Arch Pharmacol (Suppl) 302: R1 3
Heydlauf H (1969) Feric Cyanoferrat (II): Aneffective antidote in thallium poisoning. Eur J Pharmacol 6:340–344
Kamerbeck HH, Rauws AC, ten Ham M, van Heyst ANP (1971) Prussian blue in therapy of thallotoxicosis. Acta Med Scand 189:321–324
van Kesteren RC, Rauws AC, de Groot G, van Heyst ANP (1980) Thallium intoxication. An evaluation of therapy. Intensivmedecine 7:293–297
Lameijer W, van Zwieten PA (1977) Kinetic behaviour of thallium in the rat. Arch Toxicol 37:265–273
Leopold G, Furukawa E, Forth W, Rummel W (1969) Vergleichende Untersuchung der Resorption von Schwermetallen in vivo und in vitro. Naunyn-Schmiedebergs Arch Pharmacol Exp Pathol 263:275–276
Ling NG (1977) Thallium and cesium in muscle cells compete for the adsorption sites normally occupied by K+. Physiol Chem Physics 9:217–225
Lund A (1956) Distribution of thallium in the organism and its elimination. Acta Pharmacol Toxicol 12:251–259
Mulins LJ, Moore RD (1960) The movement of thallium ions in muscle. J Gen Physiol 43:759–773
Nigrović V (1963) Enhancement of the excretion of radiocesium in rats by ferric cyanoferrat (II). Int J Radiat Biol 7:307–309
Nigrović V, Catsch A (1965) Tierexperimentelle Untersuchungen zur Behandlung der akuten Eisenvergiftung. Naunyn-Schmiedebergs Arch Exp Pathol Pharmacol 251:225–232
Nordgren B (1963) The rate of secretion and electrolyte content of normal gastric juice. Acta Physiol Scand (Suppl) 202:5–82
Rauws AG (1974) Thallium pharmacokinetics and its modification by Prussian blue. Naunyn-Schmiedebergs Arch Pharmacol 284:295–306
Schäfer SG, Forth W (1980) Excretion of metals into the intestine; a comparation study in rats. In:Holmstedt B, Lauweyrs R, Mercier M, Roberfroid M (eds) Mechanisms of tpxicity and hazard evaluation. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 547–550
Schäfer SG, Nell G, Henning CH (1981) Movement of thallium (I) ions in vitro across colonic mucosa of rats. Arch Toxicol (in press)
Stevens W, van Peteyhem C, Heyndrickx A, Barlier F (1974) Eleven cases of thallium intoxication treated with Prussian blue. Int J Clin Pharmacol 10: 1–22
Weber W (1972) Grundriß der biologischen Statistik, 7. Aufl. G. Fischer, Stuttgart
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Dedicated to Prof. Dr. W. Rummel on the Occasion of his 60th Birthday on October 23d, 1981
Present address: Institut für Pharmakologie und Toxikologie, Med. Fakultüt der Ludwig-Maximilians-Universitüt München, Nussbaumstrasse 26, D-8000 München, Federal Republic of Germany
Supported by grants of the DFG Fo 58/4, Fo 58/5, and Fo 58/7
The results are part of the Doctors Thesis of C. H. Henning (1979)
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Henning, C.H., Forth, W. The excretion of thallium (I)-ions into the gastrointestinal tract in situ of rats. Arch Toxicol 49, 149–158 (1982). https://doi.org/10.1007/BF00332362
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DOI: https://doi.org/10.1007/BF00332362