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Dose-dependent excretion of DDE(1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) in rats

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Abstract

Dose-dependent excretion of p,p′DDE in rats was investigated. p,p′DDE itself was the major excreta in rats. But some o,p'isomer of DDE was detected in feces by GC-MS analysis. The excretion of p,p'DDE after a single administration was modified by its dose level.

The time pattern of p,p′DDE excretion agrees well with the modified Hill equation. The value of the equilibrium constant (K′) increases in proportion to time t after p,p′DDE administration.

Using the modified Hill equation and the linear K′ equation, the excretion rate of p,p′DDE during the experimental time t can be estimated. The estimated p,p′DDE excretion rate in feces agrees well with the measurements.

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References

  • Ando M (1977) Stimulation of hepatic microsomal drug metabolizing enzyme activity by 2,2-bis-(p-chlorophenyl),1,1-dichloroethylene (p,p′DDE) in rats. J Toxicol Sci 2: 1–9

    Google Scholar 

  • Dawes EA (1972) Quantitative problems in biochemistry, vol. 5. Churchill Livingstone, Edinburgh London, pp 186–228

    Google Scholar 

  • Fries GF, Marrow GS, Jr, Gordon CH (1972) Similarity of a polychlorinated biphenyl (Aroclor 1254) and DDE in rate of elimination from cows. Bull Environ Contam Toxicol 7:252–256

    Google Scholar 

  • Hayes WJ, Jr (1975) Toxicology of pesticides, Williams, Baltimore

    Google Scholar 

  • Jensen S, Jasson B (1976) Methyl-sulfone metabolites of PCB and DDE. AMBIO 5:257–260

    Google Scholar 

  • Peterson JE, Robison WH (1964) Metabolic products of p,p′DDT in the rat. Toxicol Appl Pharmacol 6:321–327

    Google Scholar 

  • Phillips WEJ, Hatina G (1972) Effect of dietary organochlorine pesticides on the liver vitamin A content of the weanling rat. Nutr Rep Int 5:357–362

    Google Scholar 

  • Yakushiji T, Watanabe I, Kuwabara K, Yoshida S, Koyama K, Kunita N (1979) Levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides in human milk and blood collected in Osaka Prefecture from 1972 to 1977. Int Arch Environ Health 43:1–15

    Google Scholar 

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Authors and Affiliations

  1. Environmental Health Sciences Division, National Institute for Environmental Studies, P.O. Yatabe, 305, Ibaraki, Japan

    Mitsuru Ando

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  1. Mitsuru Ando
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Ando, M. Dose-dependent excretion of DDE(1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) in rats. Arch Toxicol 49, 139–147 (1982). https://doi.org/10.1007/BF00332361

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  • DOI: https://doi.org/10.1007/BF00332361

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