Abstract
In rats, the hepatic injury and mortality elicited by an intraperitoneal injection of phalloidin are prevented by partial hepatectomy performed 1, 3, 4 or 5 days earlier.
Zusammenfassung
Partielle Leberresektion, die 1, 3, 4 oder 5 Tage vor i. p. Injektion von Phalloidin durchgeführt wird, verhindert in Ratten die durch diesen Stoff bedingte Leberschädigung und Mortalität.
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Dolara, P., Buiatti, E., Geddes, M.: Hydrocortisone protection of phalloidin-induced rat liver lysosome damage. Pharm. Res. Comm. 3, 1 (1971).
Fiume, L.: Mechanism of action of phalloidin. Lancet 1965 I, 1284.
Floersheim, G. L.: Protektion gegen Amanitatoxine. Helv. physiol. pharmacol. Acta 24, 219 (1966).
Floersheim, G. L.: Antagonistic effects to phalloidin, α-amanitin and extracts of Amanita phalloides. Agents and Actions 2/3, 142 (1971).
Frimmer, M.: Toxic cyclopeptides of the toadstool Amanita phalloides and related species. Naunyn-Schmiedebergs Arch. Pharmak. 269, 152 (1971).
Frimmer, M., Schischke, B.: Decreased toxicity of Phalloidin in partially hepatectomized rats. Naunyn-Schmiedebergs Arch. Pharmak. 272, 447 (1972).
Lutz, F., Herrmann, S., Frimmer, M.: The influence of sodium dehydrocholate on the uptake of 3H-desmethylphalloin by the perfused rat liver. Naunyn-Schmiede-bergs Arch. Pharmak. 270, 310 (1971).
Manzo, L., De Bernardi, M., Ferrara, A., Berté, F.: Drug metabolism in liver and in some non-hepatic tissues of partially hepatectomized rats. Pharm. Res. Comm. 2, 277 (1970).
Puchinger, H., Wieland, T.: Suche nach einem Metaboliten bei Vergiftung mit Desmethylphalloin (DMP). Europ. J. Biochem. 11, 1 (1969).
Saphir, O.: Liver, gallbladder, and bile ducts. In: A text on systemic pathology, Vol. 2, p. 1280. (Saphir, O., Ed.). New York: Grune & Stratton 1959.
Selye, H.: Hormones and resistance, p. 612. Berlin-Heidelberg-New York: Springer 1971.
Selye, H., Szabo, S., Tuchweber, B., Lefebvre, P.: Acute miliary necrosis resembling peliosis hepatis produced by the combination of glucocorticoid and gadolinium chloride. Proc. Soc. exp. Biol. (N. Y.) 139, 887 (1972).
Siegel, S.: Nonparametric statistics for the behavioral sciences, p. 270. New York: McGraw-Hill Book Co. 1956.
Siess, E., Wieland, O., Miller, F.: Elektronenmikroskopische Untersuchungen zur Phalloidin-Toleranz neugeborener Ratten, Mäuse und Kaninchen. Virchows Arch. Abt. B Zellpathol. 6, 151 (1970).
Tuchweber, B., Kovacs, K., Khandekar, J. D., Garg, B. D.: Effect of phenobarbital and steroids on phalloidin toxicity in rats. Toxicon 10, 357 (1972).
Tuchweber, B., Kovacs, K., Khandekar, J. D., Garg, B. D.: Peliosis-like changes induced by phalloidin in the rat liver. A light and electron microscopic study. (Under preparation).
Waelsch, H., Selye, H.: Beiträge zur Entgiftung im tierischen Organismus. Arch. exp. Path. Pharmak. 161, 115 (1931).
Wieland, T.: Poisonous principles of mushrooms of the genus Amanita. Science 159, 946 (1968).
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Tuchweber, B., Kovacs, K., Khandekar, J.D. et al. Prevention of phalloidin intoxication in rats by partial hepatectomy. Arch. Toxikol. 29, 311–316 (1972). https://doi.org/10.1007/BF00326646
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DOI: https://doi.org/10.1007/BF00326646